Psychiatry

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Chapter 23 Psychiatry

Selective Serotonin Reuptake Inhibitors (SSRIs)

MOA (Mechanism of Action)

Side Effects

Important Notes

Evidence

Tricyclic Antidepressants (TCAs)

Important Notes

TABLE 23-1 Extent of Serotonin and Noradrenaline Reuptake Inhibition among TCAs

Agent Serotonin (5HT) Noradrenaline(NA)
Clomipramine +++ +
Amitriptyline ++ ±
Imipramine + +
Trimipramine 0 +
Doxepin + ++
Nortriptyline ± ++
Desipramine 0 +++

+ symbols indicate extent of reuptake inhibition, with +++ exhibiting the greatest reuptake inhibition + exhibiting the least. 0 indicates no inhibition of the reuptake transporter for that neurotransmitter.

Serotonin Noradrenaline Reuptake Inhibitors (SNRIs)

MOA (Mechanism of Action)

Important Notes

Noradrenergic and Specific Serotonergic Antidepressants (NaSSAs)