Psychiatry

Published on 07/02/2015 by admin

Filed under Basic Science

Last modified 07/02/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 1715 times

Chapter 23 Psychiatry

Selective Serotonin Reuptake Inhibitors (SSRIs)

MOA (Mechanism of Action)

Side Effects

Important Notes

Evidence

Tricyclic Antidepressants (TCAs)

Important Notes

TABLE 23-1 Extent of Serotonin and Noradrenaline Reuptake Inhibition among TCAs

Agent Serotonin (5HT) Noradrenaline(NA)
Clomipramine +++ +
Amitriptyline ++ ±
Imipramine + +
Trimipramine 0 +
Doxepin + ++
Nortriptyline ± ++
Desipramine 0 +++

+ symbols indicate extent of reuptake inhibition, with +++ exhibiting the greatest reuptake inhibition + exhibiting the least. 0 indicates no inhibition of the reuptake transporter for that neurotransmitter.

Serotonin Noradrenaline Reuptake Inhibitors (SNRIs)

MOA (Mechanism of Action)

Important Notes

Noradrenergic and Specific Serotonergic Antidepressants (NaSSAs)