Liver Disease

Published on 25/03/2015 by admin

Filed under Pediatrics

Last modified 25/03/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 868 times

Chapter 475 Liver Disease

Because all of the clotting factors except factor VIII are produced exclusively in the liver, coagulation abnormalities are very common in patients with severe liver disease. Only 15% of such patients have significant clinical bleeding states. The severity of the coagulation abnormality appears to be directly proportional to the extent of hepatocellular damage. The most common mechanism causing the defect is decreased synthesis of coagulation factors. Patients with severe liver disease characteristically have normal to increased (not reduced) levels of factor VIII activity in plasma. In some instances, disseminated intravascular coagulation (Chapter 477) or hyperfibrinolysis may complicate liver disease, making laboratory differentiation of severe liver disease from disseminated intravascular coagulation difficult.

Buy Membership for Pediatrics Category to continue reading. Learn more here