Published on 19/03/2015 by admin

Filed under Dermatology

Last modified 19/03/2015

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Bruce E. Katz, Doris M. Hexsel and Camile L. Hexsel

Evidence Levels:  A Double-blind study  B Clinical trial ≥ 20 subjects  C Clinical trial < 20 subjects  D Series ≥ 5 subjects  E Anecdotal case reports


Cellulite consists of surface relief alterations resulting in depressions and raised areas and thus irregular appearance, such as an orange peel, cottage cheese or mattress-like appearance of the skin, located mainly on the thighs and buttocks but also on the arms, abdomen, legs, and other areas. Depressed lesions are due to the presence of fibrous septa that pull the skin surface down; raised areas result from the projection of underlying fat to the skin surface as shown on anatomical and imaging studies. Women are most frequently affected by this condition; this is due to the structure and anatomy of the subcutaneous septa compared to the structure of men. In addition, cellulite is aggravated by progressive skin laxity or flaccidity, localized fat deposition and obesity. Furthermore, other factors have been implicated in the pathogenesis of cellulite, such as hormonal, biochemical, inflammatory and circulatory factors.

Specific investigations

The diagnosis is clinical. No imaging studies are required in clinical practice.

First-line therapies

image Subcision B
image Laser, light sources B
image Radiofrequency devices B

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