Chapter 16 Cardiac output monitoring
Newer methods of assessing and optimizing cardiovascular function have been developed that allow vastly improved therapeutic intervention by anaesthetists in the perioperative period. Today, at least a dozen devices are available to measure or estimate CO quite accurately. Some of the more popular ones, based on their market presence or adoption in clinical practice, will be described in this chapter. Table 16.1 is a more comprehensive list of the available equipment and their associated technologies.
Pulmonary artery catheter
The advent of the Swan-Ganz pulmonary artery catheter (PAC) in 1970 enabled clinicians to measure cardiac output (CO) at the bedside.1
For most of the last 40 years, the PAC has been the preferred tool for haemodynamic monitoring in critically ill patients. As well as CO, the PAC can measure right heart and pulmonary artery pressures, estimate cardiac preload, and evaluate global oxygen delivery and consumption. Although such a comprehensive assessment of the circulation would be assumed to enhance patient care, there is little evidence to support this notion. Several studies have failed to show that using a PAC improved the outcome of critically ill patients in general2,3 or those with congestive cardiac failure4 or acute respiratory distress syndrome.5 Now and consequent to the emergence of the other less invasive technologies for measuring CO discussed later in this chapter, the last ten years has seen a continuing and dramatic decline in PAC usage.
The original PAC was a double lumen balloon-tipped catheter. A wide range of PACs is now available with one manufacturer producing around 30 different models. The PAC for adult use is typically a multi-lumen catheter, 110 cm in length and 7.0 or 7.5 F (French gauge) in external diameter. It is inserted via an introducer sheath (8.0–9.0 F depending on catheter model) into the internal jugular, subclavian or femoral vein. The proximal ports on the catheter are intended for administration of fluids or drugs, with their lumens appearing 19–30 cm from the distal tip of the catheter. To position the PAC, the balloon is inflated with air (1.5 ml) and the catheter is advanced with continuous pressure monitoring from the distal lumen. The typical waveforms and pressures encountered as the catheter traverses the right atrium and right ventricle on its way to the pulmonary artery (PA) should be familiar to anyone using this device (Fig. 16.1).
Modified pulmonary artery catheters
Data from the continuous CO catheter can be synchronized with the electrocardiogram to obtain right ventricular stroke volume, right ventricular end-diastolic volume, and calculate right ventricular ejection fraction. Oximetric catheters contain a fibre-optic cable and permit continuous measurement of mixed venous oxygen saturation (SvO2) from the distal pulmonary artery. Some catheters have embedded pacing wires for atrial, ventricular or dual chamber pacing. Like other central vascular catheters, the PAC can be coated with an antimicrobial agent to reduce the risk of catheter-related infection. A latex-free PAC is also available.
Limitations
1. Central venous cannulation is an invasive procedure with risks of arterial puncture, haemorrhage and pneumothorax.
2. The PAC can become knotted during insertion or later and may need to be removed surgically.
3. The indwelling introducer sheath and PAC are potential causes of sepsis and thrombus formation. The risk of infection appears to increase significantly if the catheters are left in for more than 72 h.
4. The PAC may cause arrhythmias particularly in the presence of hypothermia or electrolyte disturbances.
5. Improper balloon inflation and monitoring (e.g. failure to recognize an inadvertently wedged catheter) can result in arterial rupture, pulmonary infarction or haemorrhage.
6. The presence of the PAC may worsen pre-existing tricuspid regurgitation (TR). Over and underestimation of the true CO have been reported when there is TR. Continuous CO devices may be less affected by TR than when CO is measured intermittently.
7. CO measurement may be inaccurate in the presence of intracardiac shunts.
Oesophageal doppler method for measurement of cardiac output
Doppler effect
Oesophageal Doppler cardiac output monitors measure blood flow velocity in the descending aorta. An ultrasound probe (see below) is inserted into the distal third of the oesophagus. The ultrasound signal is backscattered by red cells travelling in the descending aorta by virtue of their differing acoustic impedence to the surrounding plasma (see Chapter 31). The returning ultrasound, is at a lower frequency (if flow direction is away from the source) and the difference between the two frequencies – the Doppler shift – is proportional to the velocity of the aortic blood flow as shown in the equation:
where:
V is velocity of red blood cells (blood flow)
C is speed of ultrasound travelling through biological tissues
Fe is emitted frequency from ultrasound device
Cosφ is cosine of angle (φ) between the sound beam axis and the direction of blood flow (angle of insonation).
CardioQ-ODM (Deltex Medical)
In the 1990s Abbott Medical marketed an early version of the oesophageal Doppler monitor, the ODMII, from this manufacturer. A major revision of the monitor resulted in the appearance of the CardioQ in 2000. The current model, the CardioQ-ODM (Fig. 16.2), was introduced in 2009. Compared to the CardioQ, the monitor screen has a higher resolution and a USB has replaced the RS232 ports to facilitate downloading of data and screenshots. The original algorithm to convert flow velocity to stroke volume is still used in the latest model, although some software enhancements have improved the monitor’s facility to store and display a variety of haemodynamic data.
Aortic flow signal
Flow signals acquired by the probe are processed by fast Fourier transformation (FFT) and represented on the monitor as a spectral density display of the distribution of red blood cell flow velocities (vertical axis) against time (horizontal axis). Descending aortic blood flow gives a positive deflection and is approximately triangular in shape (Fig. 16.3).
Figure 16.3 Ideal aortic waveform. The brightness of the signal is on the periphery of the waveform.
Note that flow in the descending aorta occurs predominantly during systole; there is minimal forward flow in diastole. Correct identification of the descending aortic waveform is a prerequisite for oesophageal Doppler monitoring. Ideally, the aortic waveform should appear triangular with the ‘brightness’ confined to the peripheral edge and an absence of signal in the central part of the triangle. This type of waveform is characteristic of a plug flow profile (present in the descending aorta) with a narrow spread of red cell velocities. Turbulent flow or unsatisfactory orientation of the transducer towards the descending aorta would show evidence of spectral dispersion (Fig. 16.4).
The Doppler frequency is proportional to flow velocity and being in the audible range may be transmitted through speakers. The two rotary controls on the monitor (Fig. 16.2) adjust the volume of the audio output and amplify the signal (gain) seen on the waveform display until the optimal signal is obtained. The same rotary controls may also be used to navigate through various menu options.