Wound Repair

Published on 10/02/2015 by admin

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186 Wound Repair

Acknowledgment and thanks to Dr. E. Parker Hays, Jr., for his work on the first edition.

Within the broad scope of emergency medical treatment, wound repair plays a prominent role. Wounds occur in all types of people—from the youngest toddlers to frail elderly grandparents. In contrast to many other conditions requiring treatment in the emergency department (ED), wounds (typically) occur independently of patients’ other medical issues. However, each patient’s unique substrate for healing is one of the two most significant factors affecting satisfactory wound healing. The second significant consideration is the characteristics of the wound itself.

Epidemiology

Approximately 12 million wounds are treated in EDs in the United States each year.1 Data on the true incidence of wounds are limited because many are thought to be treated away from the ED or urgent care setting. Of individuals with wounds seen in the ED, the majority are men.2 Wounds can clearly occur anywhere on the body, but lacerations on the upper extremities, head, and neck constitute the majority of cases encountered in EDs.

Pathophysiology

Skin, the largest organ in the body, has numerous functions, most prominently heat exchange, prevention of infection, and provision of a tactile interface with the environment. The layers of skin—epidermis, dermis, and connective tissue—all play different roles in wounds and healing. The thickest and most important layer, the dermis, serves as structural integument, supports conveyance of nutritional and waste products, and contains cutaneous nerves (Fig. 186.1).

Disruption of the skin may be caused by an infinite number of means, from simple cutlery accidents to industrial mishaps or intentional violence. Wounds that disrupt the full depth of skin are fundamentally different from those that affect only the superficial layers. Wounds that affect merely the epidermis may typically be cleansed and dressed appropriately with less concern for complications. However, it is imperative to assess seemingly superficial wounds in a diligent manner to ensure that more significant injuries are absent.

After injury, a continuum of coagulation, hemostasis, inflammation, tissue formation, and tissue remodeling quickly ensue. Each of these steps is influenced by the patient’s condition and the clinician’s wound repair skills. Clearly achieving hemostasis is a primary concern for wound repair, both to prevent exsanguination and to allow adequate visualization of the wound, as well as closure of it. Any delay in wound closure allows the later three steps of inflammation, tissue formation, and remodeling to proceed naturally, which will probably result in skin that is functional but scarred.

The aesthetic qualities of a scar are influenced by its thickness, color, and height or degree of depression. Thickness is most dependent on the width of the healing wound and on whether additional granulation tissue is necessary to fill gaps (as in secondary intention). The height of a scar is altered by the alignment and apposition of the healing skin edges, as well as by tensile and shear forces across the wound and the amount of inflammation preceding the formation of scar tissue. The increased height of a hypertrophic scar is the result of redundant tissue. If it extends beyond the original margins of the wound, it is called a keloid. Depressed scars create shadowing (consider the visibility of age-associated wrinkles), which makes them appear darker than the neighboring reflective surfaces. The color of a scar results from its vascularity and pigmentation with respect to surrounding healthy tissue. Melanocytes do not produce pigment at the same rate in injured and healing tissue or in scars as they do in normal tissue.

All these factors in scar formation vary among individuals. Some patients heal very well, whereas hypertrophic keloids invariably develop in others. However, steps to improve outcomes generally remain the same in emergency management.

Differential Diagnosis and Medical Decision Making

Injury to Underlying Structures

When sufficiently breached, skin fails in its protective role and may allow underlying structures to be injured (Fig. 186.2). Diligent assessment of the functionality of surrounding anatomic structures is of utmost importance.

Tendon function should be assessed throughout its range of motion. It may help to ask the patient to estimate the position of a body part at the time of the injury, especially with hand injuries. Tendons may be partially lacerated but their range of motion may remain intact, thereby misleading the practitioner. Patients’ complaints of pain or subjectively decreased range of motion, despite objectively normal findings on examination, should raise suspicion for partial disruption.

Nerves can be injured by the wounding mechanism itself or by iatrogenic maneuvers, especially indiscriminate ones. Clamping, blind probing, and injudicious débridement may all disrupt adjacent nerves. The hands and face are at greatest risk because nerves run in close proximity to the vasculature; zealous attempts to control bleeding vessels can result in damage to adjacent nerves. Injected anesthetics may also injure nerves as a result of pressure necrosis in finite spaces. Examples include injections into the olecranon grooves or foramina in the hard palate of the mouth.

Muscles are highly vascular tissue and are often disrupted with deep wounds. Because muscles are dynamic units, subsequent hematomas, scars, or infection can result in dysfunction. Unnecessary débridement should be avoided and bleeding controlled with direct pressure. Muscle can usually be repaired by securing the surrounding structures, thereby placing the cut surfaces of the muscle in direct apposition. Muscle tissue should be repaired directly only when the foregoing maneuver is insufficient.

Occasionally, a wound is the first sign of an underlying fracture, either because the skin was injured with the force carried onto the bone or because the broken bone edges penetrated the skin from inside.

Treatment

The emergency physician (EP) can close most wounds; some situations requiring specialist consultation are listed in Box 186.2.

Wound Preparation

To meet the goals of reducing risk for infection, minimizing damage to underlying structures, and forming a functional and cosmetically acceptable scar, preparation of the wound can be tantamount to or may surpass closure in importance. An appropriately prepared wound has been anesthetized, has been decontaminated of large particles or foreign bodies, has minimized bacterial counts, and has edges amenable to optimal repair.

Wound Cleansing and Irrigation

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