Treatment of Intractable Vertigo

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CHAPTER 92 Treatment of Intractable Vertigo

Vertigo is the illusory sensation of rotational or translational movement. Disorders producing vertigo may be classified as central disorders or peripheral disorders. Treatment of vertigo begins with conservative measures, including bedside maneuvers, vestibular rehabilitation, or pharmacologic therapy, and progresses to more invasive modalities such as intratympanic injection of aminoglycosides and surgical ablation. This chapter describes the treatment of vertigo through a discussion of its differential diagnosis, medical management, and surgical treatment.

Classification of Vestibular Disorders

Vestibular disorders are classified as central or peripheral. Central disorders involve the brainstem and cerebellum, whereas peripheral disorders involve the vestibular nerve and labyrinth. The causes, symptoms, and treatments differ between the two categories. The hallmarks of each category are summarized in Table 92-1.1,2

TABLE 92-1 Classification of Vestibular Disorders

CHARACTERISTIC CENTRAL VERTIGO PERIPHERAL VERTIGO
Onset Insidious Sudden
Auditory symptoms (hearing loss, tinnitus, aural fullness) Rarely present Common
Neurologic deficits Common Rare
Severity of symptoms

Nystagmus Direction variable, but pure vertical nystagmus is classic Horizontal or rotary Typically gaze dependent Not gaze dependent Nonfatigable Fatigable Effect of head position None Common provocative factor for vertigo and nystagmus

In general, acute unilateral peripheral disorders have a sudden onset with severe and debilitating symptoms that gradually diminish or resolve entirely within 6 to 12 weeks because of central compensation. By contrast, central disorders have a typically insidious onset and are characterized by a longer period of milder symptoms. Aside from hearing loss, neurological deficits are rarely associated with peripheral vestibular disorders. By contrast, weakness, dysarthria, and hypoesthesia are commonly associated with central disorders.

Acute unilateral peripheral disorders are characterized by horizontal jerk nystagmus that is suppressed by visual fixation after the first 24 to 72 hours. By contrast, nystagmus in central disorders can occur in any direction (although vertical nystagmus is a “classic” finding for central vertigo), it is not fatigable, and it is not subject to suppression with visual fixation. Nystagmus in central vertigo is often dependent on the direction of gaze, a finding rarely associated with peripheral vestibular disorders. With positional vertigo, the nystagmus is torsional, usually fatigable (vertigo and nystagmus dissipate after three to four repetitions of the provocative maneuver), and generally cannot be suppressed by visual fixation. Cupulolithiasis is a peripheral vestibular disorder with nonfatigable nystagmus that may be confused with central disorders.

Central Vestibular Disorders

Vertebrobasilar Insufficiency

Patients with vertebrobasilar occlusive disease most commonly suffer from weakness in the extremities, ataxia, and oculomotor or oropharyngeal cranial nerve palsies. In these patients, vertigo is also a frequent finding.3 Patients with cerebellar infarctions may complain of vertigo, diplopia, nystagmus, nausea, and ataxic gait. Wallenberg’s syndrome, produced by unilateral infarction of the dorsolateral medulla, is manifested as vertigo, hoarseness, ataxia, Horner’s syndrome, and loss of pain and temperature sensation ipsilaterally in the face but contralaterally in the trunk and limbs.3 Subclavian steal syndrome is an unusual variant of vertebrobasilar insufficiency that may cause vertigo, although the association is controversial.4

Migrainous Vertigo

Migrainous vertigo is the second most common cause of recurrent vertigo and occurs in approximately 10% of all patients with migraine headaches. The disorder arises at any age and has a strong female preponderance.5,6 During acute episodes, patients often exhibit nystagmus and a Romberg sign. Auditory symptoms are rarely present, but vague ear fullness is rather common. The clinical findings may be quite variable, thus making precise diagnosis difficult, particularly given the fact that many times there is no associated headache. In fact, there is no broad consensus regarding diagnostic criteria for this disorder. Epidemiologic data indicate that (1) symptoms may be associated with typical migraine symptoms, including auras, photophobia, phonophobia, and severe headache; (2) the vertigo may be spontaneous or provoked by motion and last from seconds to several days; and (3) the temporal relationship between headache and the onset of vertigo may vary considerably. At present, there is no clear consensus regarding the treatment of migrainous vertigo, although many different therapeutic regimens have been studied.7

Tumors

Tumors of the cerebellopontine angle are rare but potentially important causes of vertigo. These tumors more commonly produce ataxia and disequilibrium; however, they are believed to produce vertigo by a variety of mechanisms, including compression of the cerebellum or brainstem, invasion of the bony labyrinth, compression of the membranous labyrinth, or neoplastic transformation of the vestibular nerve itself.8,9 Vestibular schwannomas, for instance, may cause unilateral hearing loss, tinnitus, and disequilibrium or vertigo, depending on the nature of the labyrinthine involvement. Intralabyrinthine schwannoma, a less common variant of vestibular schwannoma with only 47 reported cases since 1917, produces vertigo in the majority of patients.10

Paraneoplastic Syndromes

Several paraneoplastic syndromes have been associated with vertigo, probably through an autoimmune mechanism.11 Paraneoplastic encephalomyelitis is an autoimmune disease associated with small cell lung cancer. The disease is typically manifested as vertigo with other cranial nerve deficits secondary to degeneration of vestibular and cranial nerve nuclei. Paraneoplastic cerebellar degeneration is associated with lung cancer, lymphoma, and breast and ovarian cancer. Patients experience rapidly progressive symptoms, including vertigo, ataxia, oscillopsia, diplopia, dysarthria, and dysphagia. Magnetic resonance imaging typically reveals atrophy of the cerebellum.12 In some cases the vestibular symptoms produced by these disorders may precede the diagnosis of malignancy.13

Peripheral Vestibular Disorders

Benign Paroxysmal Positional Vertigo

BPPV is the most common cause of recurrent vertigo. It can occur throughout life, with the peak age at onset between the fifth and sixth decades. The annual incidence of BPPV is 107 cases per 100,000 population, and it is twice as common in women as in men. Risk factors for BPPV include a history of vestibular neuritis or head trauma, although most cases are idiopathic.1620

BPPV is thought to result from canalithiasis in the majority of cases. Otoconia from the utricle dislodge and enter the endolymph of the semicircular canal system, most commonly the posterior semicircular canal, and stimulate flow of endolymph in response to changes in head position.17 An alternative form is cupulolithiasis, in which the dislodged otoconia adhere to the cupula ampullaris, thereby creating an abnormal mechanical stimulus that produces protracted deviation of the cupula in response to changes in the gravitational vector.21

Canalithiasis accounts for vertigo elicited by particular rotational movements of the head. Common positional triggers include lying down, extension of the neck to look up, bending forward, and sitting up from a supine position. A typical vertiginous episode lasts from 10 to 30 seconds and is often associated with nausea and visible nystagmus. Episodes of vertigo often occur in clusters with asymptomatic intervals between attacks. Several randomized placebo-controlled trials have demonstrated that a significant proportion of cases resolve spontaneously within a few months of onset, but the percentage of patients with self-limited cases varies considerably among these trials, ranging from 27% to 84%.21

BPPV caused by posterior semicircular canalithiasis may be revealed through the Dix-Hallpike maneuver. Proposed in 1952, this bedside maneuver quickly moves the patient from an upright seated to a supine position and then turns the patient’s head to one side and slightly extended at the neck. The procedure is then repeated by turning the head to the other side and observing the patient for nystagmus.21 Patients with horizontal canal BPPV may not demonstrate nystagmus with this maneuver.22

Meniere’s Disease

Endolymphatic hydrops, or Meniere’s disease, was first described by the Parisian physician Prosper Meniere in 1861.23 Meniere’s disease is relatively rare, with a prevalence of 218 per 100,000 persons. However, it is a relatively common cause of acute recurring episodic vertigo. Meniere’s disease may be overdiagnosed in the primary care setting.2426

The classic manifestation consists of recurrent episodes of spontaneous rotational vertigo coupled with fluctuating hearing loss, tinnitus, and aural fullness. The vertiginous episodes generally last several hours and are associated with nausea and vomiting. Hearing loss is typically progressive, predominantly affects the lower frequencies initially, and may ultimately lead to unilateral deafness (Fig. 92-1). Bilateral hearing loss develops in approximately 50% of patients.17 Management of bilateral cases is exceedingly complex.

Since its description, Meniere’s disease has been the subject of intense scientific inquiry. Even so, understanding its pathogenesis remains elusive. Current theories suggest that dysfunction of mechanisms governing the production and reabsorption of endolymph leads to distention and periodic rupture of the membranous labyrinth, which causes unilateral vestibular dysfunction. The cause of the dysfunction is unknown, although a viral insult in predisposed individuals has been proposed.2

Perilymphatic Fistula

Perilymphatic fistula (PLF) is an abnormal connection between the fluid-filled inner ear and the air-filled tympanic cavity. First proposed a century ago by Meniere, PLF remains a controversial diagnosis among neuro-otologists.31 Previous studies have documented variable signs and symptoms, and it is often difficult to identify a definite site of leakage. Nonetheless, a recent meta-analysis of these studies has revealed certain clinical patterns: (1) patients complain of sudden loss or rapid deterioration of their hearing, (2) the hearing loss tends to involve fluctuations in speech discrimination, (3) dizziness is the most common symptom and is usually described as a continuous disequilibrium with occasional episodes of positional vertigo, and (4) most patients have a combination of symptoms.3133 A significant proportion of documented cases exhibited the symptom constellation of fluctuating hearing loss, tinnitus, dizziness, and aural fullness. This clustering of symptoms is very similar to Meniere’s disease, thus confounding accurate diagnosis and treatment of these patients.34

Risk factors for this disorder include a history of stapedectomy surgery, penetrating middle ear trauma, and barotrauma.

Superior Semicircular Canal Dehiscence Syndrome

Superior semicircular canal dehiscence (SSCD) syndrome was first described in 2000. The putative pathophysiology of SSCD is thinning of the squamous temporal bone, which predisposes to dehiscence of the superior semicircular canal. In effect, acoustic energy is shunted away from the basilar membrane toward the structural defect in the otic capsule bone. SSCD syndrome is characterized by aural fullness, hyperacusis, autophony, and conductive or mixed hearing loss with a low-frequency component.35,36 Patients characteristically exhibit the Tullio phenomenon (noise-induced dizziness and eye movements) and the Hennebert sign (movement of the eyes in response to impulses of pressure in the external auditory canal). The sensitivity to loud sounds and changes in ambient pressure typically causes episodic vertigo and oscillopsia. On audiometric testing, bone conduction thresholds in the involved ear are better than in the other and may be supranormal in the low frequencies. Acoustic reflexes are present despite the apparent conductive hearing loss. Thin-section temporal bone computed tomography (CT) scans reformatted in the plane of the superior canal are diagnostic. Electrocochleography and vestibular evoked myogenic responses are particularly helpful in confirming the diagnosis in patients with a suspicious clinical picture or borderline CT findings.

Trauma

Trauma can cause either peripheral or central vertigo, depending on the mechanism of injury. Head trauma can lead to vertigo by a variety of mechanisms, including fracture of the temporal bone, creation of epileptogenic foci, induction of posttraumatic migraine, and alteration in the vertebrobasilar circulation. Transverse fractures through the temporal bone may cause disruption of the membranous labyrinth or significant damage to the cochleovestibular nerve, or both, thereby provoking severe vertigo and profound sensorineural hearing loss (SNHL). In addition, trauma patients with labyrinthine injury will experience gait unsteadiness and veering toward the affected side for several days, along with nausea and vomiting. These symptoms usually subside within 6 weeks. Longitudinal temporal bone fractures, which typically spare the membranous labyrinth and cranial nerve VIII, can still produce vertigo and disequilibrium via shearing forces or a concussive injury to the labyrinth itself. Other potential features of temporal bone fractures include discomfort about the temporomandibular joint, facial nerve palsy, and cerebrospinal fluid (CSF) otorrhea.37 Posttraumatic epilepsy occurs in approximately 5% of patients with closed head injuries. Damage to the temporal lobe, in particular, may establish epileptic foci that cause the sensation of vertigo during seizures. Alterations in the vertebrobasilar arterial circulation may occur after trauma and predispose patients to basilar artery migraine, which may produce migrainous vertigo.38

Of note, head trauma patients are also susceptible to the development of BPPV and PLF. A recent study indicated that approximately 50% of traumatic brain injury patients who complain of positional vertigo actually have BPPV.39

Neck trauma, especially whiplash injury, can cause vertigo and disequilibrium. The onset of dizziness occurs 7 to 10 days after the traumatic event, and symptoms may persist for several years. Patients typically complain of neck pain and tenderness, as well as recurrent positional vertigo and visual disturbances triggered by rotation of the head. One putative mechanism is vertebrobasilar insufficiency, but a recent study of magnetic resonance angiography in patients with whiplash injury and vertigo yielded inconclusive results.40 It is also possible that the dizziness is mediated by a pathologic disturbance in the vestibulocollic reflex despite its relative lack of importance in healthy humans.

Nonsurgical Management of Vertigo

Conservative therapeutic modalities for the treatment of vertigo include vestibular rehabilitation, canalith repositioning maneuvers (sometimes known as the Epley maneuver), and a wide variety of pharmacologic agents designed to suppress vestibular input to the central nervous system.

Vestibular Rehabilitation

Vestibular rehabilitation is a cornerstone of the treatment of many vertiginous disease processes and is particularly important in the postsurgical phase of recovery. The concept of vestibular rehabilitation for patients with iatrogenic unilateral loss of vestibular function or postconcussive disorders was first implemented in the 1940s by Cawthorne and Cooksey.4143 Since that time, vestibular rehabilitation exercises have become more tailored to the individual patient, thereby increasing therapeutic efficacy, although some of the original exercises proposed by Cawthorne and Cooksey are still used by rehabilitation specialists today. There is considerable evidence to suggest that vestibular rehabilitation alone or in conjunction with other therapeutic modalities is highly efficacious in the treatment of a wide variety of vestibular disorders.4448 However, the efficacy of vestibular rehabilitation can be compromised in the following situations: (1) bilateral loss of vestibular function, (2) central vestibular dysfunction or oversedation, (3) unstable conditions with fluctuating or progressive symptoms, and (4) medical comorbid conditions that affect proprioceptive or visual input to the central nervous system.43 Thus, patients with stable, unilateral lesions affecting the periphery of the vestibular system are most amenable to a program of vestibular rehabilitation, whereas those with central disorders require longer treatment periods and have poorer outcomes.43,44,49,50

Canalith Repositioning Maneuvers

BPPV is unusual relative to other forms of vertigo, and this condition can be promptly and effectively treated at the bedside with a series of canalith repositioning maneuvers, which were popularized by Epley in 1992.21,51,52 The objective of these maneuvers is to mobilize the displaced otoconial debris from the affected semicircular canal via a sequence of head positioning maneuvers such that the debris ultimately settles in the utricle. A meta-analysis concluded that the Epley maneuver is a safe and effective treatment strategy for BPPV in the short term, although the authors qualified this assertion with the fact that BPPV has a high rate of natural resolution and thus a type II error was possible. Moreover, there is no evidence that the Epley maneuver constitutes a definitive cure for BPPV because recurrences are common and there is a paucity of long-term follow-up of these patients.21

Pharmacologic Therapy

Glutamate appears to be the most important neurotransmitter of vestibular afferent impulses, although acetylcholine transmission via muscarinic receptors also plays a role. Histamine and γ-aminobutyric acid (GABA) receptors are also present in the vestibular nuclei. Most of the pharmacologic agents used for the treatment of vertigo are vestibular suppressants that exploit the known neurochemistry of the vestibular system, and such medications include benzodiazepines, antihistamines, and anticholinergic agents. In general, these drugs are designed to reduce the intensity of vertiginous spells and have little prophylactic benefit. The major side effect is sedation, although benzodiazepines have the additional side effect of respiratory depression in high doses. Vestibular suppressants should not be used on a chronic basis because they impair the process of vestibular compensation, and many of these medications foster physiologic dependence.53

Benzodiazepines potentiate the inhibitory action of GABA, thereby reducing pathologic vestibular input to the central nervous system. Benzodiazepines are considered by many clinicians to be the first line in the pharmacologic armamentarium for vertigo because they are the most effective class of medications for this symptom. Lorazepam and diazepam are particularly effective for the treatment of acute exacerbations of Meniere’s disease. The nongeneric form of lorazepam (Ativan) has the advantage of a sublingual delivery mode, which is valuable for patients with considerable nausea and emesis. Sometimes benzodiazepines are used for symptomatic management in the acute phase of a vestibular crisis caused by labyrinthitis or vestibular neuritis. Although benzodiazepines may actually facilitate the early stages of central compensation by helping mobilize the patient earlier,54 patients should not continue this medication after the acute symptoms resolve to avoid physiologic dependence and permit vestibular compensation to proceed to completion.

Meclizine, dimenhydrinate, diphenhydrinate, and promethazine are type 1 histamine receptor antagonists. The mechanism by which these drugs reduce the severity of vertigo is unclear but most likely involves antagonism of either histamine receptors in the vestibular nuclei or central cholinergic activity. These drugs must cross the blood-brain barrier for therapeutic effect; thus, second-generation antihistamines are not efficacious in the treatment of vertigo. Meclizine is the most popular choice among clinicians, especially for Meniere’s disease.53

Anticholinergic agents (propantheline, transdermal scopolamine) function as nonspecific muscarinic receptor antagonists and have a characteristic side effect profile secondary to systemic parasympathetic blockade (mydriasis, xerostomia, and so on). These medications should be used with caution in elderly patients because of the significant risk for delirium. Transdermal scopolamine is useful for patients with chronic nausea or emesis, but cutaneous hypersensitivity to the patch can develop.

Currently, there is no evidence to support the use of antiviral medications for the treatment of vestibular neuritis despite the viral etiology of this disorder. A recent German study involving methylprednisolone and valacyclovir failed to show any therapeutic benefit from valacyclovir alone, although a benefit was observed with methylprednisolone.55 These findings have been corroborated by the work of Ariyasu, Morales-Luckie, and others, who demonstrated that oral steroids reduce the severity of vertiginous spells and expedite recovery from an acute episode of vestibular vertigo.56,57

Although Meniere’s disease is amenable to vestibular suppressants, the best conservative treatment strategy for this disorder consists of salt restriction and diuretics, both of which minimize hydropic change within the membranous labyrinth.58 The target range for salt consumption is 1.5 to 2 g daily. A dietitian can help patients select the appropriate foods to meet this objective. Patients should be advised that the therapeutic benefit of salt restriction may not become evident for several weeks. Some patients note that certain substances such as caffeine and nicotine may exacerbate their symptoms. Thiazide diuretics reduce the frequency of vertiginous spells in patients with Meniere’s disease but have a variable effect on hearing loss.59,60 Triamterene, a potassium-sparing diuretic, can be administered when thiazide diuretics are contraindicated. Generally, a combination of triamterene and hydrochlorothiazide is prescribed and continued for 3 to 6 months after resolution of the acute spells.

Currently, there is no consensus concerning the treatment of migrainous vertigo. Medications that are ordinarily administered for migraine prophylaxis (beta blockers, calcium channel blockers, tricyclic antidepressants, pizotifen, and flunarizine), as well as carbonic anhydrase inhibitors, have been used in the setting of migrainous vertigo with some degree of success.7,61

Surgical Management of Intractable Vertigo

Patients who fail medical therapy are often candidates for more invasive therapeutic modalities, depending on the nature of the disease process and various patient factors that influence recovery. Appropriate selection of patients is absolutely imperative to secure a satisfactory outcome, particularly for those with peripheral vestibular dysfunction, in whom procedures to unilaterally ablate labyrinthine function might be indicated. Accurate lateralization of pathology and assessment of central compensation are critical determinants of surgical success.

Surgery for Benign Paroxysmal Positional Vertigo

BPPV often resolves spontaneously and is characteristically amenable to simple bedside maneuvers; however, in rare circumstances the condition is refractory to conservative therapies and is so debilitating that surgical intervention is warranted.62 There are two invasive modalities for the treatment of refractory BPPV: singular neurectomy and posterior semicircular canal occlusion.

Posterior Semicircular Canal Occlusion

Posterior semicircular canal occlusion was developed in 1990 by Parnes and McClure.64 The procedure involves exposure of the posterior semicircular canal via the mastoid, with subsequent permanent obstruction of the canal to eliminate the flow of endolymph, which secondarily renders the cupula unresponsive to angular acceleration. Of the 97 patients reported in the literature, 94 experienced complete cure and only 4 had postoperative hearing loss.62,65 Both singular neurectomy and posterior semicircular canal occlusion are relatively rare procedures, increasingly so as the Epley maneuver has become more standardized in practice. Nonetheless, posterior semicircular canal occlusion appears to be the safer approach to intractable BPPV.62

Surgery for Perilymphatic Fistula

The definitive strategy for managing PLF has yet to be fully established, mostly because the diagnostic criteria for this enigmatic disease remain so elusive. There is no “gold standard” for diagnosis of PLF,34,6872 and firm clinical criteria for surgical intervention have yet to be developed. Despite this lack of consensus, management of this disorder entails a graduated approach toward surgical intervention, as guided by the level of clinical suspicion. Penetrating injuries of the middle ear should be explored promptly, as should patients who have previously undergone stapedectomy. Nonsurgical management of suspected acute PLF associated with head trauma or barotrauma can lead to full resolution of symptoms.49 Conservative therapy for PLF consists of 1 week of bed rest with 30-degree elevation of the head. Patients should avoid activities that involve straining or lifting during this time because the Valsalva maneuver can exacerbate symptoms. Conventional medications for the treatment of vertigo, including benzodiazepines, scopolamine, and antiemetics, can be quite effective in the interval. If suspicion of PLF is low and hearing is stable, a therapeutic trial of vestibular rehabilitation is indicated. Patients who fail to improve with these therapeutic measures are candidates for surgical intervention. The classic surgical approach for PLF involves patching the oval or round window with a graft of earlobe fat, temporalis fascia, or tragal perichondrium. Notably, positive studies report that 90% of selected patients experience some improvement in their vestibular symptoms, but the effect of surgery on hearing is far less predictable.31,7375

Surgery for Meniere’s Disease

Medically refractory Meniere’s disease is the most common indication for vestibular surgery despite the fact that 70% to 95% of patients with Meniere’s disease respond adequately to medical therapy. Surgical intervention is reserved for patients who have failed 6 to 12 months of conservative therapeutic measures, including dietary modification and maximal medical therapy. A variety of invasive options are available for the treatment of Meniere’s disease, including intratympanic injections of aminoglycosides, use of the Meniett device, endolymphatic sac surgery, and vestibular ablation.

Meniett Device

The observation that changes in ambient pressure could improve vertiginous symptoms in patients with Meniere’s disease provided the necessary impetus to develop the Meniett device, a machine that generates intermittent pressure impulses that reach the inner ear through a tympanostomy tube.79 The precise mechanism by which the device ameliorates the symptoms of Meniere’s disease is unclear. One plausible explanation is that pressure impulses from the machine reach the inner ear via the round window and cause a reduction in the volume of endolymph, possibly by increasing flow through the utriculoendolymphatic valve. Recent studies by Gates and colleagues have demonstrated a significant reduction in the severity and frequency of vertiginous symptoms in patients using this device.80,81

Endolymphatic Sac Surgery

Endolymphatic sac surgery is a highly controversial surgical approach to the management of intractable Meniere’s disease. The French otologist Georges Portmann introduced the procedure in 1927, which entails fenestration of the endolymphatic sac to decompress the endolymph. The procedure has undergone several minor suggested technical modifications since its inception.8286 A review of the literature to date, which involves 1880 documented cases, reveals an initial vertigo control rate of 86% with improved hearing in 22%, although hearing was adversely affected in 25% of patients. Other potential complications of this procedure include CSF leak and injury to the facial nerve.85

The crux of the controversy surrounding endolymphatic sac surgery arises from a seminal study by Thomsen and colleagues in 1981 that compared endolymphatic sac surgery with a “sham” cortical mastoidectomy in a double-blind, controlled manner.87 The study demonstrated no statistically significant difference in outcome between the two approaches.8789 The logical conclusion from these data is that the reported efficacy of endolymphatic sac surgery is merely a placebo effect. Some authors have theorized that the observed effect is a reflection of the natural history of Meniere’s disease, which despite the progressive deterioration of hearing toward permanent SNHL, tends to gradually resolve vis-à-vis the vestibular symptoms.90 A nonspecific effect from anesthesia itself may also be a factor in the improvement noted after endolymphatic sac surgery.91

Welling and associates reanalyzed the data from these trials with modern statistical methods and did find statistically significant differences between the placebo and experimental groups with respect to postoperative dizziness and tinnitus that favored endolymphatic sac surgery.85 Furthermore, the authors pointed out the inadequate statistical power of Thomsen and associates’ original study, which may have precluded the detection of potentially significant differences in outcomes beyond dizziness and tinnitus. Given the controversy surrounding the efficacy of endolymphatic sac procedures relative to the natural history, some otologists do not believe that adequate evidence exists to support the use of endolymphatic sac surgery for control of vertigo in patients with Meniere’s disease.

Vestibular Ablative Surgery

Vestibular ablative surgery is designed to eliminate residual labyrinthine function in the pathologic ear. In general, ablation is reserved for patients who have failed medical therapy and can adequately compensate for unilateral loss of vestibular function because the procedures themselves lead to transient worsening of symptoms in the postoperative phase. Vestibular ablative surgery entails two distinct approaches: vestibular neurectomy and labyrinthectomy. The fundamental difference between the two is that labyrinthectomy obliterates residual hearing in the affected ear, whereas most approaches to vestibular neurectomy are designed to preserve it. Even so, vestibular neurectomy carries an inherent risk for injury to the cochlear nerve with resultant hearing loss. These surgeries are most commonly performed to control vertigo in cases of intractable Meniere’s disease; however, they can be used in other clinical scenarios involving unstable or progressive unilateral vestibulopathy.92,93

Considerations for Ablative Surgery

Careful selection of patients for vestibular ablative surgery is absolutely central to securing a satisfactory outcome. Vestibular neurectomy is the preferred approach in patients wishing to preserve residual hearing in the affected ear. However, these patients should be advised that vestibular ablation does not completely halt the natural progression of Meniere’s disease with respect to progressive SNHL. In fact, profound SNHL may ultimately occur even after vestibular neurectomy with no postoperative complications. Furthermore, vestibular neurectomy carries a distinct set of risks that are not associated with labyrinthectomy, which must be weighed against the potential benefits of preserved residual hearing.94,95

Accurate identification of the pathologic labyrinth is an important component of the preoperative evaluation. Fluctuating or progressive asymmetric hearing loss is an excellent indicator of the affected side, even if the hearing loss has preceded vertigo by an extended period. Likewise, unilateral reduction of responsiveness to caloric irrigation is usually a reliable lateralizing sign.96,97 Poorer indicators of the affected ear include tinnitus, aural fullness, the direction of nystagmus, and rotary chair asymmetries. Tinnitus and aural fullness in the patient’s better functioning ear may signify contralateral extension of the disease process. This should be viewed as a relative contraindication to these surgical approaches.

In addition to lateralizing the pathology, the potential for central vestibular compensation must be assessed because this factor markedly affects surgical outcome. Patients experience transient worsening of their symptoms postoperatively, and recovery is ultimately predicated on the patient’s ability to compensate centrally. In general, stable vestibular pathology in the setting of incomplete central compensation, including impaired vestibular compensation secondary to central extension of the disease process, is a contraindication to ablative surgery. Persistence of spontaneous or positional nystagmus, rotational chair asymmetry, or sensory organization test abnormalities on dynamic posturography is indicative of incomplete central compensation. Such patients should undergo a complete trial of vestibular rehabilitation.98

Labyrinthectomy

Although labyrinthectomy was commonly used for treating suppurative labyrinthitis in the late 1800s, the first labyrinthectomy specifically for vertigo was performed in 1904 by Lake and Milligan, two British otolaryngologists.99,100 Cawthorne and Schuknecht helped popularize labyrinthectomy as a treatment specifically for Meniere’s disease in the 1940s and 1950s.101,102 Indeed, for much of the 20th century, labyrinthectomy was a mainstay in the treatment of medically refractory vertigo, principally because of its safety and high efficacy. However, the predominance of labyrinthectomy has been challenged in the past 30 years with the advent of intratympanic injections of gentamicin and vestibular neurectomy, both of which appear to be highly efficacious and relatively safe, with the theoretical advantage of preservation of hearing.

Labyrinthectomy is appropriate for patients who have intractable vertigo secondary to a unilateral vestibular disorder with severe to profound SNHL on the affected side. There are two approaches to this procedure: the transcanal (sometimes termed oval window labyrinthectomy) and the transmastoid approach. The former involves a less invasive approach through the external auditory canal but does not reliably ablate vestibular function.103 The latter is widely regarded as the gold standard for vestibular ablation because it allows the surgeon to completely visualize and remove the membranous labyrinth (semicircular canals, utriculus, and sacculus). The procedure is highly efficacious, with published control rates for vertigo exceeding 90%, but it requires expertise in transtemporal surgical approaches, including detailed knowledge of the complex neurovascular and labyrinthine anatomy of the temporal bone.104108

The principal disadvantage of labyrinthectomy via the transcanal or transmastoid approach is complete ipsilateral hearing loss, although this concern is negligible in patients with profound SNHL preoperatively. The most important postoperative complications associated with labyrinthectomy include a very low risk for injury to the facial nerve and CSF leakage.108 All patients who undergo labyrinthectomy must subsequently endure a transient period of worsening disequilibrium that typically subsides within 2 months, provided that vestibular compensation proceeds as anticipated. However, in some patients the disequilibrium becomes chronic, an adverse outcome that probably results from poor vestibular compensation or active disease in the contralateral ear. The former is a significant concern in the elderly, who have a higher frequency of prolonged postoperative disequilibrium than younger patients do.108

Vestibular Nerve Section

The first sectioning of the eighth cranial nerve in a patient with vertigo was performed by R. H. Perry in the early 1900s.109 Despite several attempts by different surgeons around the turn of the century, the high morbidity and mortality associated with the operation caused most surgeons to abandon the procedure in favor of labyrinthectomy. Walter Dandy and Kenneth George McKenzie revitalized neurectomy as a viable surgical option for the treatment of intractable vertigo. They developed the concept of selective vestibular neurectomy (i.e., division of the vestibular nerve with sparing of the cochlear nerve) by performing this operation in the 1930s and early 1940s on hundreds of patients with Meniere’s disease; they boasted cure rates for vertigo that exceeded 90% with a low rate of postoperative facial paresis and only two deaths postoperatively.77,110112 Despite this remarkable success, contemporary surgeons were more comfortable with transmastoid labyrinthectomy than with the craniotomy associated with vestibular neurectomy.78 In effect, labyrinthectomy and endolymphatic sac surgery remained the preferred surgical approaches for the treatment of intractable vertigo until the advent of a microsurgical extradural approach to the internal auditory canal and improved neuroanesthesia in the latter half of the 20th century, which ushered in multiple technical variations of vestibular neurectomy.77,78

In theory, selective sectioning of the vestibular nerve spares the cochlear nerve and thus residual hearing in the affected ear. In practice, outcomes with respect to postoperative hearing loss are quite variable, which may reflect a technical flaw inherent in the operations themselves. Currently, there are several different approaches to selective vestibular neurectomy: middle fossa neurectomy (MFVN), retrolabyrinthine neurectomy (RLVN), retrosigmoid neurectomy (RSVN), combined retrolabyrinthine/retrosigmoid neurectomy (RRVN), and endoscopically assisted. The best approach remains a subject of controversy, especially given the surgical community’s historical preference for labyrinthectomy and the increasing popularity of intratympanic injections of gentamicin. Each technique has its own advantages and disadvantages. In general, postoperative hearing loss is a significant concern with MFVN, but less so with the posterior fossa approaches. The technical details of these operative approaches are beyond the scope of this chapter, and detailed discussion is available elsewhere.78,113

Middle Fossa Vestibular Neurectomy

In the 1960s, House proposed an extradural approach to the internal auditory canal in which the superior vestibular nerve could be transected.114 In the 1970s, Fisch, Glasscock, and others extended the dissection to include transection of not only the superior vestibular nerve but also the inferior division and removal of Scarpa’s ganglion. These additions improved the efficacy of MFVN significantly (Fig. 92-2).78 MFVN entails a preauricular craniotomy followed by drilling of the bony roof of the internal auditory canal to expose the branches of the vestibular nerve, which are sectioned.

Published vertigo control rates after complete sectioning of the vestibular nerve range from 94% to 98%, which rivals the efficacy of labyrinthectomy and other forms of selective vestibular neurectomy. Selective division of the superior vestibular nerve (sparing innervation to the posterior semicircular canal) reduces the efficacy considerably, with reported control rates ranging from 72% to 78%, but leads to better preservation of residual hearing than total sectioning does.115,116 Although the middle fossa approach can be efficacious, the procedure is quite challenging from a technical standpoint because it involves dissection in a very delicate portion of the temporal bone in close proximity to the inner ear, the cochlear blood supply, and the facial nerve. In effect, the principal disadvantages of the middle fossa approach include relatively high rates of postoperative hearing loss and transient facial paresis (21% to 24% and 6% or higher, respectively).115118 Because of the technical difficulty of the approach and the relatively high rates of hearing loss and facial weakness, MFVN never gained widespread popularity in the United States or Europe.78

Retrolabyrinthine Vestibular Neurectomy

In light of the technical difficulties associated with MFVN, a posterior fossa approach was developed in the 1970s that offered retrolabyrinthine exposure of the eighth cranial nerve in the cerebellopontine angle with less cerebellar retraction than needed for RSVN. The retrolabyrinthine approach was first described by Hitselberger and Pulec in 1972 in a case report involving a patient with trigeminal neuralgia. Silverstein, however, developed the retrolabyrinthine approach as a viable surgical treatment of intractable vertigo by performing the first RLVN procedure in 1977.119,120 In effect, the posterior fossa approach has become the most popular technical variation of vestibular neurectomy and accounts for approximately 95% of all vestibular neurectomies performed in the United States (Fig. 92-2).78

RLVN is technically easier than the middle fossa approach. After elevation of a skin-muscle flap, the surgeon performs a complete mastoidectomy and skeletonizes the sigmoid sinus so that it can be retracted posteriorly. The dura anterior to the sigmoid sinus is incised and the cerebellum is retracted to expose the eighth cranial nerve at the cerebellopontine angle. The vestibular nerve is then selectively divided in close proximity to the cochlear and facial nerves. After vestibular nerve section, the presigmoid dura is closed if possible and the mastoid is obliterated with abdominal fat. Even so, because watertight dural closure is not generally possible, there is a possibility of CSF leakage.

RLVN appears to be quite effective, although its efficacy is dependent on the cause of the unilateral vestibulopathy. Kemink and Hoff reported complete resolution of vertigo in 92% of patients in whom Meniere’s disease was diagnosed, but in only 77% of those with other causes.93 Cure rates in other published studies are more variable but consistently show a statistically significant difference in efficacy between patients with Meniere’s disease (76% to 97%) and those with other causes (28% to 77%).78,93,118,119,121128

The potential advantages of RLVN include a lower rate of facial nerve injury and postoperative hearing loss than with the middle fossa approach, which stems from the relative technical safety of the transtemporal approach used for RLVN.93,120,129 One series of 50 patients demonstrated no instances of facial paresis, an improvement over the middle fossa approach.93 Proponents of RLVN claim a lower rate of postoperative hearing loss than seen with MFVN. The results of Kemink and Hoff, which demonstrated hearing preservation in 92% of patients, support this claim.93 However, other studies have yielded considerable variability with respect to hearing loss (7% to 58% of patients).78,93,118,119,121128 A confounding factor in the analysis is that the natural history of Meniere’s disease is one of progressive SNHL, which is probably unaffected by these surgical interventions. However, some authors have theorized that accumulation of bone dust in the oval window during the procedure may contribute to the hearing loss and account for some documented cases of SNHL in the immediate postoperative period.127,130

There are several disadvantages to RLVN. One drawback is that the eighth cranial nerve is exposed only within the cerebellopontine angle, where it can be difficult to discern cochlear from vestibular nerve fibers. This raises the possibility of incomplete vestibular ablation or inadvertent sectioning of auditory nerve fibers, both of which are corroborated by the significant variability in published outcomes. In addition, postoperative CSF leakage occurs in 4% to 12% of patients, significantly more commonly than in patients who undergo RSVN.78,118,119,121128,130 The incidence of wound infection and aseptic meningitis is similar to that of RSVN, with these complications occurring in less than 5% of patients.

Retrosigmoid Vestibular Neurectomy

Dandy and McKenzie developed RSVN in the 1930s. The procedure entails a posterior fossa craniotomy with incision of the dura posterior to the sigmoid sinus and retraction of the cerebellum to expose the eighth cranial nerve in the cerebellopontine angle. The principal advantage of this approach, when compared with RLVN, is that it permits watertight closure of the dura more frequently, thereby reducing the risk for CSF leakage to less than 4%.131 Like RLVN, exposure of the eighth cranial nerve in the cerebellopontine angle can be suboptimal, which raises the specter of inadvertent damage to the cochlear nerve. The published data relate an incidence of postoperative hearing loss of 7% to 45% after RSVN.123,132,133 Nevertheless, RSVN appears to be quite efficacious in the treatment of vertigo. Follow-up of Dandy’s extensive series of more than 600 cases demonstrated cure rates ranging from 75% to 90%.

The principal disadvantage of any retrosigmoid approach is the considerable risk for postoperative headache—approximately 1 in 10 patients, although an incidence as high as 50% has been reported.123,134136 The cause of postoperative headache remains a subject of continued debate in the surgical community, but several theories have been proposed. Some believe that adhesion of the cervical musculature to the dura, a natural consequence of the suboccipital craniectomy, leads to traction on the dura with head movement. Others have postulated that bone dust in the subarachnoid induces a chemical meningitis or interferes with resorption of CSF. Alternatively, injury to the greater and lesser occipital nerves during incision or retraction may be the cause. Other complications associated with RSVN include CSF leakage, wound infection, and aseptic meningitis, although the risk for these complications is less than 5%.135

RSVN has undergone several technical modifications since its inception, some of which were fueled by a desire to circumvent the issue of severe postoperative headache. Silverman and associates altered the primary incision and closure and omitted any drilling of the internal auditory canal, with a resultant decrease in the incidence of postoperative headache to 3.8% 2 years after surgery.135 Fukuhara and colleagues simply drained 60 to 90 mL of CSF through a lumbar drain preoperatively and reduced the incidence of postoperative headache to 3.6%.137 Several authors have performed cranioplasty with calvarial bone grafts or other material to avoid dural adhesions, but the benefit of this maneuver vis-à-vis postoperative headache is controversial.138,139

To address the problem of suboptimal exposure of the vestibular nerve in the cerebellopontine angle, Silverstein and coworkers modified RSVN in the mid-1980s by adding an approach to the internal auditory canal (RSVN-IAC). Like RSVN, a retrosigmoid craniotomy is performed to access the nerve in the angle. A dural flap is then elevated from the temporal bone, and the posterior wall of the internal auditory canal is drilled to expose the superior vestibular and singular nerves for selective division distal to their separation from the cochlear fibers. The advantage of this approach when compared with RSVN is the potential for more definitive sectioning of the vestibular branches with less risk to the cochlear nerve. In practice, these technical modifications have resulted in excellent control of vertigo (approximately 90% of patients) with a low incidence of CSF leakage, but the incidence of severe postoperative headache was markedly increased, thus curbing enthusiasm for this approach.78,134,140

Combined Retrosigmoid–Internal Auditory Canal/Retrolabyrinthine Vestibular Neurectomy

In the late 1980s, Silverstein and colleagues developed a hybrid approach combining elements of the RSVN-IAC and RLVN approaches to address the problems of postoperative headache and suboptimal eighth nerve exposure. They termed the novel technique combined retrosigmoid/retrolabyrinthine vestibular neurectomy.141 RRVN entails a limited mastoidectomy with removal of the bone covering the sigmoid sinus. The dura is then incised posterior to the sigmoid sinus, which is retracted forward. The surgeon next follows the posterior wall of the temporal bone toward cranial nerves IX to XI until the arachnoid layer near the jugular foramen is identified. Fenestration of this layer near cranial nerve IX releases the CSF in the area, which causes the cerebellum to fall away from the temporal bone and obviates the need for cerebellar retraction. The surgeon can then identify cranial nerve VIII in the cerebellopontine angle and proceed with selective vestibular neurectomy in a manner analogous to RLVN. However, if surgical exposure of cranial nerve VIII is suboptimal in the cerebellopontine angle, the surgeon has the option of making a small incision in the dura over the temporal bone as a prelude to drilling the internal auditory canal for transection of the superior vestibular nerve and avulsion of the posterior ampullary nerve, thereby effecting a complete vestibular neurectomy. RRVN also permits watertight closure of the dura.

The theoretical advantages of these technical modifications are significant. First, if exposure of cranial nerve VIII is suboptimal in the cerebellopontine angle, RRVN allows the surgeon to expose the nerve within the internal auditory canal. This reduces the probability of incomplete vestibular ablation or inadvertent sectioning of the cochlear nerve secondary to inadequate exposure in the cerebellopontine angle. Second, the less extensive exposure of the posterior fossa (with extradural drilling that leaves most of the mastoid intact) reduces accumulation of bone dust in the subarachnoid space. In addition, the forward retraction of the sigmoid sinus with subsequent CSF release eliminates the need for cerebellar retraction. These modifications should translate into a lower incidence of postoperative headache. Third, the watertight dural closure afforded by RRVN should reduce the incidence of CSF leakage, the most frequent complication of RLVN.

In practice, RRVN appears to be safe and highly efficacious. A retrospective review of 210 cases by Goksu and coauthors reported complete resolution of vertigo in 90% of patients with Meniere’s disease, and an equal proportion of patients experienced no change or improved hearing postoperatively. Furthermore, the incidence of CSF leakage was less than 1%, and there were no documented cases of facial paresis.142 A review by Silverstein and Jackson revealed that postoperative headache and CSF leakage occurred at a negligible rate in RRVN patients—a significant improvement over RSVN and RLVN, respectively—and yielded similar results with respect to the cure rate for vertigo (85%) and preservation of preoperative hearing levels (80%).78

Endoscopically Assisted Vestibular Neurectomy

Endoscopic selective vestibular neurectomy is one of the latest additions to the surgical armamentarium for Meniere’s disease. Although endoscopic neurosurgery dates back to the early 1900s, use of the endoscope to treat intractable vertigo was developed in the 1990s, thus far with promising results. A case series by Miyazaki and colleagues involving 345 patients with medically refractory Meniere’s disease who underwent minimally invasive RSVN demonstrated complete or partial relief of vertigo in 96% of patients, with CSF leakage in 4%, and no documented cases of postoperative facial paresis or hearing loss.143 The Miyazaki series notwithstanding, there is a relative paucity of outcome data after endoscopic vestibular neurectomy for the treatment of refractory Meniere’s disease. Endoscopically assisted neurosurgery has several theoretical advantages over microscopic approaches to vestibular neurectomy, including better visualization of internal anatomic structures, less cerebellar retraction, and narrower surgical exposure, thereby reducing the risk for postoperative CSF leakage. However, there are depth perception issues associated with endoscopy that may compound the difficulty and danger of these operations. Furthermore, one runs the risk of thermal injury to delicate structures from endoscopic heating during the procedure.143,144

Suggested Readings

Badke MB, Pyle GM, Shea T, et al. Outcomes in vestibular ablative procedures. Otol Neurotol. 2002;23:504.

Baloh RW. Prosper Meniere and his disease. Arch Neurol. 2001;58:1151.

Bretlau P, Thomsen J, Tos M, et al. Placebo effect in surgery for Menière’s disease: nine-year follow-up. Am J Otol. 1989;10:259.

Catalano PJ, Jacobowitz O, Post KD. Prevention of headache after retrosigmoid removal of acoustic tumors. Am J Otol. 1996;17:904.

Chia SH, Gamst AC, Anderson JP, Harris JP. Intratympanic gentamicin therapy for Ménière’s disease: a meta-analysis. Otol Neurotol. 2004;25:544.

Eisenman DJ, Speers R, Telian SA. Labyrinthectomy versus vestibular neurectomy: long-term physiologic and clinical outcomes. Otol Neurotol. 2001;22:539.

Fukuhara T, Silverman DA, Hughes GB, et al. Vestibular nerve sectioning for intractable vertigo: efficacy of simplified retrosigmoid approach. Otol Neurotol. 2002;23:67.

Furman J. Benign paroxysmal positional vertigo. N Engl J Med. 1999;341:1590.

Gacek R. Singular neurectomy in the management of paroxysmal positional vertigo. Otolaryngol Clin North Am. 1994;27:363.

Glasscock ME3rd, Miller GW. Middle fossa vestibular nerve section in the management of Ménière’s disease. Laryngoscope. 1977;87:529.

Goksu N, Yilmaz M, Bayramoglu I, et al. Combined retrosigmoid retrolabyrinthine vestibular nerve section: results of our experience over 10 years. Otol Neurotol. 2005;26:481.

Green RE. Surgical treatment of vertigo, with follow-up on Walter Dandy’s cases: neurologic aspects. Clin Neurosurg. 1959:141.

Green RE, Douglass CC. Intracranial division of the eighth nerve for Meniere’s disease: a follow-up study of patients operated on by Dr. Walter Dandy. Ann Otol Rhinol Laryngol. 1951;60:610.

Hain TC, Yacovino D. Pharmacologic treatment of persons with dizziness. Neurol Clin. 2005;23:831.

Hilton M, Pinder DK. The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. Cochrane Database Syst Rev. 2002;1:CD003162.

House JW, Hitselberger WE, McElveen J, et al. Retrolabyrinthine section of the vestibular nerve. Otolaryngol Head Neck Surg. 1984;92:212.

House WF. Surgical exposure of the internal auditory canal and its contents through the middle, cranial fossa. Laryngoscope. 1961;71:1363.

Jackler RK, Whimey D. A century of eighth nerve surgery. Otol Neurotol. 2001;22:401.

Kemink JL, Hoff JT. Retrolabyrinthine vestibular nerve section: analysis of results. Laryngoscope. 1986;96:33.

Kemink JL, Tellian SA, el-Kashlan H, et al. Retrolabyrinthine vestibular nerve section: efficacy in disorders other than Meniere’s disease. Laryngoscope. 1991;101:523.

Leveque M, Labrousse M, Seidermann L, et al. Surgical therapy in intractable benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2007;136:693.

Levine SC, Glasscock M, McKennan KX. Long-term results of labyrinthectomy. Laryngoscope. 1990;100:125.

Miyazaki H, Deveze A, Magnan J. Neuro-otologic surgery through minimally invasive retrosigmoid approach: endoscope assisted microvascular decompression, vestibular neurotomy, and tumor removal. Laryngoscope. 2005;115:1612.

Schuknecht HF. Ablation therapy for the relief of Meniere’s disease. Laryngoscope. 1956;66:859.

Silverstein H, Jackson LE. Vestibular nerve section. Otolaryngol Clin North Am. 2002;35:655.

Silverstein H, Norrell H, Smouha E, et al. Combined retrolab-retrosigmoid vestibular neurectomy. An evolution in approach. Am J Otol. 1989;10:166.

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