Epidemiology

Except for ethanol, no other alcohols are fit for human consumption, and they are properly termed toxic alcohols. Ethylene glycol, methanol, and isopropanol are the most common toxic alcohols associated with human poisoning.¹ Less commonly reported but still clinically important toxic alcohols are propylene glycol, diethylene glycol, and other glycol ethers. Unintentional ingestion from a mislabeled or contaminated container occurs commonly in children, whereas intentional ingestion of a toxic alcohol as an ethanol substitute or for self-harm occurs more commonly in adults. If untreated, toxic alcohol poisoning can result in metabolic acidosis, renal failure, blindness, central nervous system (CNS) injury, pulmonary edema, or death.

Ethylene glycol is present in antifreeze solutions, deicing solutions, foam stabilizers, and chemical solvents.² Methanol is a component of windshield-washing solutions, gas-line antifreeze solutions, solvents, and brake cleaners.³ Isopropanol is found in rubbing alcohol, aerosols, and other cosmetic products. Propylene glycol is commonly found as a diluent in parenteral medications such as phenytoin, diazepam, and lorazepam.⁴ The other toxic glycols can be found in various household and industrial cleaners, paints, resins, and solvents.

More than 35,000 toxic alcohol exposures are reported yearly to the American Association of Poison Control Centers.¹ Most cases are individual poisonings. However, contamination of beverages or pharmaceutical products has resulted in epidemic poisonings, including two significant outbreaks, in India and in Haiti in the 1990s, from diethylene glycol that affected hundreds of victims.⁵

Definitive laboratory confirmation of toxic alcohol poisoning is usually not immediately available to the emergency physician. However, early recognition of poisoning and emergency department (ED)–initiated interventions significantly improve patient outcomes and reduce the occurrence of alcohol-specific complications.⁶

Pathophysiology

Most toxic alcohol poisonings occur by oral ingestion. Significant methanol poisoning has also been reported to occur by inhalation of brake cleaning products, and isopropanol poisoning has occurred through transcutaneous absorption in children treated for fevers at home with rubbing alcohol baths.^7,8 Complete absorption is rapid by any route, each alcohol has a small volume of distribution (0.5 to 0.8 L/kg), and metabolism to toxic organic by-products occurs through hepatic alcohol dehydrogenase (ADH) (Figs. 151.1 and 151.2).

Fig. 151.1 Ethylene glycol metabolism pathway.

Fig. 151.2 Methanol metabolism pathway.

Toxicity from the parent products is limited to local mucous membrane irritation and CNS depression. The term toxic is specifically related to the production of different toxic by-products (oxalic acid and formic acid) by each of these alcohols. Ethylene glycol metabolism results in renal failure from deposition of oxalic acid in renal tubules.² Methanol metabolism to formic acid results in blindness from direct injury to the retinal and optic nerves.³

Because the rate of metabolism through ADH varies by alcohol type and by individual variability in cytochrome P-450 genetic expression, clinical onset of worrisome symptoms can be delayed by 1 to 36 hours.^2,3 Furthermore, the concomitant presence of ethanol may delay metabolism to the toxic by-products because ethanol has a higher affinity for ADH than the toxic alcohols and competitively inhibits metabolism of these alcohols to toxic by-products until the serum ethanol concentration drops to less than 100 mg/dL.

Isopropanol is unlike ethylene glycol and methanol in that it is not metabolized to an organic acid. Instead, it is metabolized to acetone, an osmotically active CNS depressant, which leads to profound inebriation (Fig. 151.3).⁸

Fig. 151.3 Isopropanol metabolism pathway.

Presenting Signs and Symptoms

Other clinical findings range from mild to life-threatening, depending on the type of alcohol and the dose consumed. Because the clinical toxicity from these alcohols results from the accumulation of specific toxic metabolites, some patients may appear relatively asymptomatic before the manifestation of significant symptoms. Hypotension with reflex tachycardia is common in significant ingestions because of the vasodilatory effects common to all alcohols. In patients with ethylene glycol or methanol poisoning, routine laboratory analysis classically shows anion gap metabolic acidosis and an enlarged osmol gap. Patients with isopropanol poisoning typically have only an enlarged osmol gap, because isopropanol is not metabolized to any organic acids. Patients poisoned with the other toxic alcohols, such as diethylene glycol or butyl ethers from household cleaning products, have acidosis of varying degrees and inconsistently demonstrate an enlarged osmol gap.

Typical Variations

Ethylene glycol poisoning that progresses to significant organic acid accumulation can cause Kussmaul respirations from severe acidosis, cerebral edema, and seizures. Multiple reports have described various self-limited cranial nerve palsies associated with ethylene glycol. Tubular necrosis from local oxalate deposition and renal failure are common. Because oxalic acid precipitates calcium, dysrhythmias and tetanic spasms secondary to hypocalcemia have been reported.

Metabolism of methanol to formic acid gives rise primarily to neurologic and ophthalmologic findings. Patients who are not obtunded may have severe headache, vomiting, dizziness, and amnesia. Cerebral edema, necrosis, and infarcts have been identified on intracranial imaging. Visual disturbances range from simple blurring to “snowstorm” vision to blindness. Worrisome eye findings include sluggish nonreactive pupils, papilledema, a hyperemic optic disk, and retinal edema.

Isopropanol ingestion is associated with a fruity breath odor from acetone accumulation and CNS depression that is reportedly two to four times more profound than would be expected from an equivalent dose of ethanol. Vomiting and hemorrhagic gastritis have also been reported in patients with isopropanol ingestion.

Propylene glycol is metabolized to lactic acid. This poisoning typically occurs iatrogenically from the diluent present in parenteral medications such as phenytoin and various benzodiazepines. Accumulated lactate in these cases has been associated with profound hypotension and cardiac dysrhythmias.

Diethylene glycol and the other butyl ethers have been associated with renal tubular necrosis, hepatitis, and pancreatitis.