Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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Chapter 59 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

Keith R. McCrae, J. Evan Sadler, Douglas B. Cines

Table 59-1 Proposed Classification Scheme for Thrombotic Microangiopathies

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ADVANCED UNDERSTANDING OF ETIOLOGY

Infection induced

Shiga and verocytotoxin (Shiga-like toxin)–producing bacteria
Streptococcus pneumoniae

Disorders of complement regulation

Genetic disorders of complement regulation
Acquired disorders of complement regulation, for example anti-FH antibody

ADAMTS13 abnormalities

ADAMTS13 deficiency secondary to mutations
Autoantibodies against ADAMTS13

Defective cobalamine metabolism

Quinine induced
ETIOLOGY NOT FULLY UNDERSTOOD

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