The anaesthetic workstation

Published on 27/02/2015 by admin

Filed under Anesthesiology

Last modified 22/04/2025

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 3 (1 votes)

This article have been viewed 7873 times

Chapter 4 The anaesthetic workstation

The anaesthetic workstation (Fig. 4.1) has evolved over the years from the simple inhaler for the admixture of volatile anaesthetics, through anaesthetic machines with calibrated delivery of inspired agents to the current modern workstation complete with integral ventilator, breathing system and patient and machine monitoring. Automated record keeping systems allow integration of the machine into institutional information networks and, more recently, online access to expert systems for decision support (see Chapter 22, Information Technology and the Anaesthetic Workstation). Such systems remain rare and in spite of the diminishing costs and expanding capabilities of electronic-microprocessor-based control systems, simple pneumatic anaesthetic machines with needle-valve flowmeters and conventional vaporizers still dominate in UK hospitals. There has been no ‘revolution’ in anaesthetic machines as yet.

Products offered to a market place by successful companies reflect a balance of technology, economics and what the end user is or will be willing to engage with. In this respect the particular machines described in the latter section of this chapter when viewed as a whole, demonstrate how anaesthetists have only gradually come to be prepared to use ‘fly by wire’ technology: electronically controlled machines operated through a computer interface. Even within anaesthesia such technology is not new; along the way machines with iterations of such technology such as the Engstrom Elsa1 have perished in the market where the devices really were ‘before their time’.

When the anaesthetic machine appears a physically, if not intellectually, impenetrable box with opaque control systems operated through a simple video screen, it is tempting to think that the study of joints in metal tubing, pressure regulators, mechanical hypoxia prevention systems and flow valves is somewhat anachronistic. It may be, but caution is advised: the user manual for a state of the art workstation such as the Dräger Zeus runs to 346 pages (it is difficult to envisage more than a singular instruction sheet for the original Boyle’s trolley) and reflects the complexity of the processes underlying these devices. The logic and control of such systems is an elaboration of what has gone before and an understanding of the processes is necessary if we are to be able to cope with the machines and to demand better performance or deal with fault conditions. Additionally it seems we are occasionally required to relearn lessons of the past.2

Throughout the changes above, developments have been driven by the need for safety addressed by the inclusion of fail-safe systems, and by ‘the designing out’ of the possibilities of dangerous user errors. This aspect of the workstation may be regarded as having developed through successive generations of improvements and modifications having been incorporated, such that the ‘anaesthetic machine’ component of a modern workstation is still usually recognizable as a descendant of the first-generation Boyle’s trolley. Over time, technological safety features have become enshrined in national and international standards which are largely adhered to. As such, an analysis of critical incidents may help to inform a logical approach to the understanding of the safety features and design of modern machines, and for this reason such a section is included in this chapter.

One notable change over the last few years has been the narrowing gap between anaesthesia ventilators and intensive care ventilators. Software-driven, electronically controlled devices are seen that, if not identical in technology to the ITU types, are at least capable of emulating most ventilatory modes if desired. Simple purely mechanical ventilators are seen now only in devices purpose built for the developing countries (see Chapter 27). The reader is referred to Chapters 9 and 10 for more detailed information on ventilators.

Functions of the modern workstation

Inhalational anaesthesia is still the most commonly used technique worldwide. A few years ago, the AneoTivas, a much simpler anaesthetic machine designed for the delivery of two intravenous anaesthetic agents only (with integral respiratory support and patient monitoring) failed to get past the prototype stage. The anaesthetic workstation, itself an elaboration of the continuous flow anaesthetic machine, has thus developed to accurately and continuously deliver a safe mixture of gasses and vapours for the administration of anaesthesia. The component parts of the modern workstation represent its various and extended functions:

Development of the anaesthetic workstation

The overriding principle governing design of the anaesthetic workstation has been to increase safety in anaesthesia. The invisible and odorless nature of the main gasses used has meant that the focus of safety in the machine has had to be prevention of the accidental delivery of incorrect gasses and gas mixtures. This commences with gas-specific connections to wall and cylinder supplies and continues through non-interchangeable gas-specific pipework within the machine and from there on to standardized arrangements of flow control valves. Along the way, fail-safe devices prevent delivery of nitrous oxide (N2O) in the event of failure of the oxygen (O2) supply which is given the highest alarm priority. Carbon dioxide (CO2), another ill wind, has been largely eradicated from anaesthetic machines, further reducing potential error sources.

Integrated and modular designs

The first machines were solely for gas and volatile agent delivery. Monitoring was a purely clinical modality and a function of the anaesthetist. As individual monitors became available they were connected to or placed onto the machine with a view to creating effectively what would now be termed an anaesthesia workstation. The next generation of modern devices briefly attempted to integrate these parts into one harmonious unit (such as the Narkomed 2 and 3 series from North American Dräger discussed in the 4th edition of this text, and below).

Since then though, the design of the anaesthesia workstation has moved away from an integrated single entity towards a modular approach of combining various component parts, perhaps even from different manufacturers, to produce devices adapted for many applications and with less in-built obsolescence. This has been necessitated by the unforeseen growth in the range of possible monitoring modalities which no manufacturer could hope to encompass in one device, and the expansion of the functions of the anaesthesia workstation.

Twenty years ago, when the majority of machines consisted of a stainless steel trolley with a number of monitors stacked on top, at least one manufacturer was making an integrated anaesthesia workstation where gas delivery and patient monitoring were one singular entity. The Narkomed 2a had two CRT screens showing all settings and monitored variables. However, by today’s standards, the in-built monitoring was rudimentary. Indeed, it is difficult to imagine how we could once again have a scenario where one in-built monitor can satisfy all requirements unless it has the facility for individual monitoring modalities to be interchanged.

The answer has been to return to a modular approach. The basic pneumatic anaesthetic machine is contained within a chassis or framework to which is added:

Patient and machine monitoring

Monitoring of patient physiological variables is often approached separately to the monitoring of machine settings and function. Currently, the favoured arrangement is to have at least two monitors. One monitor is integral to the anaesthetic machine as part of the ventilator control area and displays the related parameters such as airway pressure and volume changes which are needed for the microprocessor control of the ventilator. This screen invariably also displays the back bar and/or breathing system oxygen concentration. Beyond measurement of inspired oxygen (FiO2) and simple flow and volume measurements from the breathing system, patient respiratory gas monitoring is usually a function of a second and separate patient physiological monitor. The patient monitor is most conveniently attached on a swing-out arm, allowing the patient, machine and display to be aligned in a comfortable arc for ease of viewing and access.

Separate patient monitoring also has the advantage of allowing standardization of monitors between the operating theatres and ward areas in hospitals. This, together with modular monitoring systems, means that machines can be designated to a variety of surgical scenarios which may have differing needs in terms of patient physiological monitoring.

Monitors can still be integrated such that information from each of the monitoring systems may be prioritized by a computer before any alarm is sounded, although where patient and machine monitoring are largely separate, so far this has tended not to happen. The data may be displayed in the most convenient fashion for easy and quick assimilation and may then be collated to provide a permanent record. Monitoring, where combined with automatic record keeping, can thus also log and reveal both the equipment and the anaesthetist’s performance for the purposes of medical audit.

Electronics: monitoring or control?

The modern anaesthetic workstation has been invaded by electronics. Despite many predictions over the years, the role of electronics has remained until recently largely one of monitoring rather than control. The Engström ELSA and the PhysioFlex – machines that exemplified the ‘fly by wire’ approach of computer control of the anaesthesia machine – were presented in the fourth edition (1998) of this text, but were no longer in production by the time of the fifth edition (2005). It is only very recently that such machines have re-emerged to be seen in use. Curiously, the PhysioFlex is once again gracing the pages of this book, but this time incarnated as the Zeus, the original manufacturer having been incorporated into Dräger Medical of Germany and the concept further developed by them. Apart from microprocessor control of the sophisticated ICU type anaesthetic ventilators, there has not been a massive expansion in the control role of electronics. Whether this reflects a desire on the part of anaesthetists for an intrinsic empathy with the principal tool of their trade or an unwillingness to tackle new concepts remains unanswered.

The flow of gasses through the workstation has largely remained under pneumatic and direct mechanical control. There are currently only very few machines offering electronic servo control of gas flow and/or vapour concentrations. Although needle valves (see below) remain ubiquitous for control of gas flows, many machines do use electronic monitoring (and display) of the flow rates instead of rotameters (see Chapter 2).

The electronically controlled machines discussed later in this chapter represent only a small proportion of the machines currently in use.

The anaesthetic delivery system

Given that the most popular designs of anaesthesia workstation are essentially modular (in terms of separating patient monitoring from gas delivery), this part of the chapter will concentrate on the gas delivery aspect of the workstation.

The basic design of delivery systems is common to a wide variety of manufacturers and may be considered under a number of headings. A working knowledge of these parts of the machine should allow rapid assimilation of the salient features of any new device.

A typical machine consists of:

The compressed gas attachments

Compressed gasses to be used by the anaesthetic machine (air, oxygen and nitrous oxide) are usually supplied by two methods: cylinders and pipelines.

Cylinders

The cylinders are clamped onto the machine by a yoke arrangement and secured tightly using a wing-nut (Fig. 4.2). To prevent installation of the wrong gas cylinder to a yoke, the cylinder heads are coded with appropriately positioned holes that match pins on the machine yoke. This is called a pin index system, for which there is an internationally agreed standard (ISO 407:2004) (see Fig. 1.5). A thin neoprene and aluminium washer (Bodok seal) is interposed between the cylinder head and yoke to provide a gas-tight seal when the two are clamped together.

Cylinder yokes are also fitted with filters and one-way spring-loaded non-return (check) valves. The one-way valve prevents retrograde leaks when a cylinder is removed.

A leak of not more than 15 ml min–1 through an open yoke is acceptable in new machines. However, in older machines the non-return valve may not be as efficient owing either to the design (the valve not being spring loaded) or to wear and tear, and could result in greater than acceptable backpressure leaks. These leaks, when occurring unexpectedly, have been shown to alter the composition of the gas leaving the flowmeter block and have resulted in the delivery of a hypoxic gas mixture to an attached breathing system (see section on Flowmeters). Blanking plugs (dummy cylinder heads) are available and should be inserted into all empty yokes to overcome this problem (Fig. 4.3).

Pressure (contents) gauges

The pressure in cylinders and pipelines is measured by Bourdon-type gauges (see Fig. 2.6). The gas entry to the pressure gauge has a constriction so as to smooth out surges in pressure that could damage the gauge, as well as to prevent total and rapid loss of gas should a gauge rupture. The gauges are labelled and colour coded for each gas, according to the standards for each country. They are also calibrated for each gas used on the machine. The scale on the gauge extends to a pressure at least 33% greater than either the filling pressure of the cylinder or pipeline pressure (at a temperature of 20°C). Each cylinder yoke may be fitted with a gauge or, alternatively, a single-cast brass block may be used to house the NIST/DISS pipeline connection, cylinder yoke, pressure regulator and housings for the pressure gauges (Fig 4.4). This minimizes the number of connections and potential leaks, but is a somewhat dated arrangement now.

Pressure regulators (reducing valves)

Pressure regulators are used on anaesthetic machines for three main reasons:

Not only is the pressure reduced, but it is also kept constant, and for this reason this type of valve is more correctly termed a pressure regulator.

Working principles

In Fig. 4.6, the chamber C is enclosed on one side by the diaphragm D. As gas enters the chamber through the valve V, the pressure in the chamber is increased and the diaphragm is distended against its own elastic recoil and the force from the spring S. Eventually the pressure rises high enough to move the diaphragm far enough to close valve V. The pressure at which this occurs may be varied by adjusting the screw X so as to alter the force exerted by the spring S. If gas is allowed to escape from the outlet of the chamber, the pressure falls and valve V reopens. When the regulator is in use, a steady pressure is maintained in the chamber by the partial opening of valve V.

In another form of regulator (Adams valve), the push-rod is replaced by a ‘lazy tongs’ toggle arrangement (Fig. 4.7), which reverses the direction of the thrust transmitted from the diaphragm.

The accuracy of regulators

Let us consider that the push-rod is pushed downward by two forces: the compression in the spring and the elastic recoil of the diaphragm (Fig. 4.8). Let these be added together and represented by S. The force that opposes S consists of two parts: the high pressure (P) of the gas pushing on the valve V over an area of a; and the low pressure (p) acting on the diaphragm over an area A, so:

image

Thus, if S remains constant, as P falls, p rises so that as the cylinder empties, the regulated pressure increases. In fact, as P falls, the valve V will have to open further to permit the same flow rate. The spring expands and therefore its compression is reduced, and in the same way the tension in the diaphragm is reduced. Therefore, as P falls, there is a small reduction in S, which partially reverses the effect illustrated here.

In the Adams valve (Fig. 4.9), it can be seen that the pressure P exerted by the high-pressure gas to open valve V is assisted by the spring and the recoil of the diaphragm S. These forces jointly oppose the force exerted by the low-pressure gas on the diaphragm, so:

image

Now as P falls, so does p; therefore the regulated pressure falls slightly as the cylinder pressure drops. At the same time the valve V opens slightly and this, by allowing the spring to expand, reduces S, which slightly accentuates the fall in p. The fall of p can be minimized by making S great compared with Pa.

There are several types of pressure regulator available, the choice being dependent on:

For low-pressure regulators, the diaphragms are frequently made of rubber or neoprene, whereas in those for higher pressures the diaphragm is made of metal. Adjustments to alter the regulated pressure should be made only by service engineers. On some anaesthetic machines, ‘universal’ regulators are used. These operate equally well from an input of 420 kPa (60 psi) from the pipeline, as from a maximum of 20 000 kPa (2900 psi) from cylinders and are of the Adams type. The term ‘universal’ is also used in a different context, as below.

Relief valves on regulators

Safety blow-off valves are often fitted on the downstream side of regulators to allow the escape of gas if, by accident, the regulators fail and allow a high-output pressure. With a regulator designed to give a pressure of 420 kPa (60 psi), the relief valve may be set at 525 kPa (70 psi). These valves may be spring loaded (Fig. 4.10), in which case they close when the pressure falls again, or they may operate by rupture, in which case they remain open until repaired. As a further safety feature, a flow restrictor (usually in the form of a simple pin hole orifice) on the high pressure inlet side of the regulator, limits maximal flow from the cylinder to between 70 and 150 l min–1, ensuring that in the event of regulator failure the high-pressure relief valve can dump the maximal flow without further pressure rises.

Secondary pressure regulators

Several factors cause the machine working pressure (420 kPa in the UK) to fluctuate by up to 20%. For example, at times of peak demand in a hospital, pipeline pressures may well drop by this amount. Similarly, if an auxiliary outlet on the anaesthetic machine is used to drive a ventilator with a very high sudden and intermittent gas demand, a similar pressure drop will occur before the pipeline or cylinder is able to restore the supply. These pressure fluctuations produce parallel fluctuations in flowmeter performance. A second (secondary) regulator set below the anticipated pressure drop smoothes out the supply, minimizing these fluctuations. This is important in machines incorporating mechanically linked anti-hypoxia systems attached to the flowmeter bank (see below), as these systems assume that the oxygen supply pressure is constant in order to achieve an accurate flow of gas. A mechanically linked system would not be able to detect altered gas flow rates caused by changing pressures. Furthermore, secondary regulators also prolong the accurate supply of oxygen to the flowmeter if there is a gradual failure of the oxygen supply (i.e. cylinder emptying) prior to the oxygen failure warning device being activated.

Regulators have to meet stringent criteria before being installed. They are required to withstand pressure of 30 mPa (megaPascals) without disruption and their output should not vary more than 10% across a wide flow range (100 ml min–1 to 12 l min–1). They should also be fitted with a pressure relief valve that opens at a pressure not exceeding 800 kPa (UK).

Gas-tight connections within the machine

The various components within the anaesthetic machine are joined to each other by a series of pipes. Although now almost entirely made of high-density nylon, previously copper piping was standard, and is still used occasionally; hence these components are also briefly described below. Piped medical gas conduits within hospital walls and ducting are still entirely of metal.

Whilst there is no standard for the design of gas piping within the machine, with the advent of nylon tubing, manufacturers tend to use pipes of differing diameters and/or sometimes colour for the different gasses to reduce the risk of accidental misconnection during servicing and assembly (see Fig 4.5A where the white tubing is for oxygen and the blue and black, respectively, for nitrous oxide and air).

Joints in metal tubing

These may be permanent or detachable. Two metal pipes may be permanently joined by one of two methods:

The adjacent surfaces are then bonded together by brazing (applying a molten filler alloy whose melting temperature is above 430°C) or hard soldering (a similar principle using an alloy with a lower melting point). After making such a joint it is important that all traces of flux are removed. Flux is a material applied to the surfaces to be bonded, allowing the molten filler to spread more evenly. More recently, a system of brazing copper pipes and brass fittings without flux has been evolved. This is used particularly for medical gas pipeline installations.

Where provision has to be made for disconnection and reconnection of a joint, a union is used. This consists of two parts held together in a gas-tight manner, usually by a nut or cap, which screws onto a parallel male thread. Figure 4.11C shows a ball and cone (or cone seated) union, in which the seating is by direct metal-to-metal contact. A flange (or flat seated) union (Fig. 4.11D) requires a washer to complete the seal. With pipes carrying oxygen, this washer should be of non-flammable material.

For some other purposes tapered threads (Fig. 4.11E) may be used and the seal made either by screwing them down extremely tightly or by interposing a sealing compound such as PTFE (polytetrafluoroethylene/Teflon) in the form of a tape. The joint between the valve block and the body of a medical gas cylinder, for example, is sealed by a metal foil between two tapered threads and is designed to melt at high temperatures, allowing gradual release of cylinder contents.

Valve glands

Where a valve spindle passes from an area of high pressure to one of low pressure, provision must be made to prevent the leak of gasses along the line of the spindle. This is achieved by means of a gland. In Figure 4.13, the nut ‘N’ must be screwed down sufficiently tightly to ensure that the packing is applied so closely to the spindle that no gas can escape by this route. There is provision for the nut to be tightened down further to prevent leaks as the packing wears.

The principle can be used for a high-pressure gland, such as that of an oxygen cylinder (see Chapter 1), or in a low-pressure gland such as that in a flowmeter (Fig. 4.14). In the case of high-pressure valves, a special type of leather or long-fibre asbestos was at one time used for the packing, but modern glands are filled with specially shaped nylon. Those in low-pressure flow control valves may be filled with rubber, nylon, neoprene or cotton.

‘O’-rings

In certain circumstances, the packing of a stuffing box may be replaced by an ‘O’-ring (Fig. 4.12A). If the valve spindle S and the casing C are suitably designed, an ‘O’-ring is all that is required to prevent leakage at this point. ‘O’-rings can withstand remarkably high pressures and yet cause very little friction between the spindle and the casing.

Flowmeters (rotameters)

Gas at a suitably regulated pressure from either a pipeline supply or cylinder, is passed through a flowmeter, which accurately controls the flow of that gas through the anaesthetic machine. The anaesthetic machine conventionally has a bank of flowmeters for the various gasses used (Fig. 4.15). Flowmeters are described briefly here, but more detailed information can be found in Chapter 2.

A typical flowmeter assembly (Fig. 4.14) consists of:

Gas entering the sight tube pushes the bobbin up it in proportion to the gas flow. The bobbin floats and rotates inside the sight tube, without touching the sides, giving an accurate indication of the gas flow. The sight tube is made leak-proof at the top and bottom of the flowmeter block by ‘O’-rings, neoprene sockets or washers. The glass or plastic sight tubes, with their own bobbins, are individually calibrated (in l min–1) for their specific gasses at a temperature of 20°C and an ambient pressure of 101.3 kPa and are non-interchangeable. Misconnection is made physically impossible by constructing the glass sight tubes of different diameters and/or lengths or by using a pin index system at each end.

Flow control valves in the UK have to meet standards set down in BS 4272 and BS EN ISO 60601-2-13:2006 which stipulate that:

The flowmeter block

In the UK and many other countries, the flowmeters are traditionally arranged in a block with the oxygen flowmeter on the extreme left, the nitrous oxide on the extreme right and those for compressed air and carbon dioxide (where fitted) in between these. However, some machines, such as those originally manufactured by Datex-Ohmeda (now GE Healthcare) and Blease (Spacelabs Healthcare), incorporate a system that delivers a minimum concentration of oxygen (e.g. 25%), and requires the oxygen and nitrous oxide flow control valves to be adjacent, as they are linked by a sprocket and chain or cogwheel.

The flowmeters are mounted vertically and usually next to each other, in such a way that their upper (downstream) ends discharge into a manifold. Traditionally, this was unfortunately arranged in such a way that if there were a leak in, say, the central tube, oxygen would be lost rather than nitrous oxide. As a result, a hypoxic mixture could be delivered to the patient (Fig. 4.16A). In most modern machines, oxygen is the last gas to flow into the manifold so that a leak would not lead to such a hypoxic mixture (Fig. 4.16B). As a solution to the same problem, in some countries such as the USA and Canada, the order of the flowmeters in the block has been reversed, with oxygen on the right. However, this too has previously (before the advent of hypoxic guard interlinks) led to patients receiving a hypoxic mixture because anaesthetists have not been made aware of the transposition.

The practice of removing carbon dioxide cylinders (and in the past cyclopropane) from their yokes has exposed a further hazard in older machines. Oxygen can be lost via a retrograde leak through a carbon dioxide (or cyclopropane) flowmeter, even when intact, if the corresponding needle valves are inadvertently left open. Gas can track back from the manifold via the flowmeter and open needle valve to the unblocked cylinder yoke and escape. The one-way (check) valves fitted to cylinder yokes in some machines were never intended to provide a perfect gas-tight seal under all conditions. They were not spring loaded because they were designed to work against high back pressures rather than the relatively low back pressures produced in the retrograde leak. This leak may be increased by adding an extra resistance to flow downstream of the flowmeter block (i.e. some types of minute volume divider ventilator or high-resistance vaporizer), which effectively increases the gas pressure in the flowmeter block. All empty cylinder yokes for air, carbon dioxide and cyclopropane (where these still exist) should be fitted with blanking plugs (Fig. 4.3) so as to prevent this problem. Modern standards (BS EN 740:1999) stipulate that a maximum retrograde flow of 100 ml min–1 is acceptable, or 10 ml h–1 if the fault condition causing this is not alarmed.

Recent increased interest in low-flow anaesthesia systems has created a demand for flowmeters that can more accurately measure flows below 1 l min–1. This is achieved by the use of two flowmeter tubes for the same gas. The first is a long thin tube accurate for flows from 0 to 1000 ml min–1 that complements the second conventional tube calibrated for higher flows (1–10 l min–1 or more). Both are activated from the same flow control valve. These ‘cascade’ flowmeter tubes for each gas are arranged sequentially (Fig. 4.15) so that when the flow control valve is opened the low-flow tube is seen to register first. At flows over 1 l min–1, the bobbin in the low-flow tube is no longer easily visible.

Anti-hypoxia devices

Anaesthesia machines in use now must either not be capable of delivering a gas mixture with less than 20% oxygen or have a means to give an alarm at an oxygen concentration of below 20% in the inspiratory gas which must be separate from any ‘add on’ patient respiratory gas monitoring (EN 740:1999). Of these approaches it has proven ultimately safer and simpler to design a system whereby it is physically impossible to set the nitrous oxide and oxygen flow rates to give hypoxic mixtures. Some approaches taken by manufacturers are discussed below.

Mechanical devices

The ‘Link 25’ system (Ohmeda) (Fig. 4.17) incorporates a chain that links the flow control valves for nitrous oxide and oxygen. There is a fixed sprocket (cog) on the nitrous oxide spindle that relays its movement to a larger cog on the oxygen flowmeter spindle via a chain. The oxygen cog moves along a static, hollow worm gear, through which the oxygen flowmeter spindle passes. As the nitrous oxide flowmeter control is turned counter-clockwise (increasing the nitrous oxide flow), the chain link moves this larger cog nearer to the oxygen flowmeter control so that, when a 25% oxygen mixture is reached, it locks on to the oxygen control knob and moves it synchronously with any further increase in nitrous oxide flow. The oxygen flow control can of course be independently opened further, but cannot be closed below a setting that if nitrous oxide is flowing, will produce less than 25% oxygen in the mixture. Other manufacturers use interlinking gears (Fig. 4.18) to achieve the same effect. This type of mechanical link, however, has some limitations:

A further safety feature of this system includes a mechanical stop fitted (Fig. 4.18) to the oxygen flowmeter control valve, ensuring that a preset minimum standing flow (typically between 25 and 250 ml min–1) of oxygen is maintained even when the valve is fully closed. This flow, of course, can occur only when the machine master switch for all the gasses is switched on.

Pneumatic devices, e.g. Pneupac ratio system

Originally designed and launched by Medical and Industrial Equipment Ltd UK (MIE) in 1988, this system relies on a ratio mixer valve (Fig. 4.19) to ensure that the oxygen concentration leaving the flowmeter block never drops below 25% of the nitrous oxide concentration. When the machine master switch is turned on, a basal flow rate of 200–300 ml min–1 of oxygen is established (Fig. 4.20A). This is independent of, and bypasses, the ratio mixer valve. Nitrous oxide supplied to one side of the valve exerts a pressure on the diaphragm which is opposed by the pressure exerted by oxygen on a separate but coupled larger diaphragm (Fig. 4.20B). Inward movement of the oxygen diaphragm is linked to the opening of a poppet valve that allows more oxygen to flow through the O2 chamber thus balancing the opposing forces. Any increase in the flow of nitrous oxide results in an increase in pressure on the nitrous oxide side of the diaphragm, causing the latter to move towards the compartment containing oxygen. The ratio of the area of the diaphragms is so constructed that the oxygen flow rate will increase by a ratio of 25% of any increase in the nitrous oxide flow rate. This increased oxygen flow is independent of the main oxygen flow control valve that bypasses the ratio mixer valve and, of course, can be adjusted independently. The ratio mixer valve does not work in reverse as it takes a single passive N2O connection from downstream of the N2O flow control valve whilst taking O2 from upstream (before) of the O2 flow control valve; hence, if the nitrous oxide flow rates are reduced, the oxygen flows remain as set before by the O2 flow control valve. The double diaphragm arrangement also means that rupture of a diaphragm will not result in contamination of the O2 flow by N2O.

Electronically controlled anti-hypoxia devices (Penlon Ltd)

In this system, a paramagnetic oxygen analyzer continuously samples the gasses mixture leaving the flowmeter bank. If the oxygen concentration falls below 25%, a battery-powered electronic device sounds an audible alarm and the nitrous oxide supply is cut off. This results in an increase in the oxygen concentration and, as a result, the nitrous oxide supply is temporarily restored. If the oxygen flow rate has not been increased, the nitrous oxide disabling system is reactivated and the alarm will again sound. The whole process is repeated, thus providing an intermittent oxygen failure alarm and at the same time assuring a breathing mixture with more than 25% oxygen (although the total flow rate will be lower than intended).

If the oxygen supply fails completely, there is a continuous audible alarm. The power is provided by a maintenance-free lead-acid battery that is kept charged by the mains electricity supply while the machine is in use and will continue to operate in the absence of a mains supply for 1.5 h. If the audible alarm is activated during this period it will sound for 20 min, after which a visual and audible ‘low battery’ warning is given. If for some reason the lead-acid battery is not adequately charged at the beginning of an anaesthetic session, the nitrous oxide supply (as well as medical air in US versions) is disabled and cannot be used. However, under no circumstances is the oxygen supply interrupted. This alarm is in addition to the standard oxygen failure warning device (Ritchie whistle, see below).

Penlon stopped installing this electronic system of hypoxia protection in 2001, largely for reasons of cost, but many of their machines are still currently in use with this technology. Penlon now use a mechanical interlink. (See below, Specific machines, Dräger Primus for a further example of electronic control of oxygen ratio).

The back bar

Strictly speaking, the term ‘back bar’ describes the horizontal part of the frame of the machine, which supports the flowmeter block, the vaporizers and some other components. However, it is often used loosely to also include those components and the gaseous pathways interconnecting them. In fact, in modern machines, the latter are often housed within the framework.

The vaporizers are mounted, either singly or in series, along the back bar, downstream from the flowmeter block. Traditionally, vaporizers were bolted onto the back bar and linked to each other by tapered fittings. The various manufacturers employed different sizes of tapers and mounting positions but these were superseded by the provisions of BS 3849 (UK), which recommended 23 mm ‘cagemount’ tapers. (The term cagemount originally refers to a type and size of tapered connection for a reservoir or rebreathing bag that has a small wire cage fitted to its inlet to prevent the neck of the bag from being obstructed, when the latter is empty and collapsed. The cagemount taper for vaporizers, though no longer used in the West, is still in use in many parts of the world.)

Modern vaporizers are designed so that they can easily be removed from the back bar and replaced by those for another agent. Systems in which vaporizers may be detached are generally regarded as an advance over the permanent cagemount system. Ease of removal has resulted in a greater flexibility in the choice and use of agents, and also ensures that anaesthetic machines do not have to be taken out of use to allow the servicing of the vaporizers.

Thus, the back bar provides mounting blocks as described below. The Ohmeda ‘Selectatec’ fitting is perhaps the most popular in the UK but most machine manufacturers now offer their machines with a choice of vaporizer mount.

The Ohmeda ‘Selectatec’ System

Each Selectatec station on the back bar has two vertically mounted male valve ports (Fig. 4.21). Between these inlet and outlet ports is an accessory pin and a locking recess. The matching vaporizer assembly has two female ports between which there is a locking assembly and a recess to accommodate the pin. The vaporizer is lowered on to the male valve ports and the locking knob is turned to fix it into the recess on the back bar (Fig. 4.21A). Successive generations of GE /Ohmeda vaporizers are labelled sequentially and, although the essential design of the back bar mounting system has not changed, the accessory pin has been added to prevent use of Tec 3 and previous generations on the modern back bar (see below).

‘O’-rings on the male valve ports ensure a gas-tight fit. The two female ports on the vaporizer have recessed spindles (TEC 4 and above) that, when the vaporizer is switched on, protrude through the gas-tight seals of the male valve ports on the back bar. The ball valves (which provide the seals) in the male ports are displaced downwards occluding the back bar, and gas from the back bar is diverted into the vaporizer (Fig. 4.21B, station 3). TEC 3 vaporizers had fixed spindles that automatically depressed the ball valves in the male valve ports when the vaporizer was lowered on to the back bar assembly. Gas, therefore, passed through the head of the vaporizer even when it was not switched on or even locked on. This arrangement obviously had a greater potential for gas leaks and has been modified by the retractable spindle assembly on the TEC 4, 5, 6 and 7.

These models also incorporate a ‘safety interlock’. This consists of an extension rod that protrudes sideways from a vaporizer as it is turned on, and displaces the equivalent rod on the vaporizer beside it, preventing the latter from being switched on. On a three-station back bar, there is a plastic lever (Fig. 4.21) linking stations 1 and 3. Should station 2 be empty, the lever links the extension rods between vaporizers 1 and 3 to ensure that only one vaporizer can be turned on at any one time. Tec 3 vaporizers had no safety interlock and this is yet another reason for their use being precluded by the fitting of the accessory pin. Presently machines are rarely specified with a three station back bar and this plastic lever is seldom required.

Back bar working pressures

The flowmeter tubes in the flowmeter bank have, as a rule, been calibrated for gas flows assuming no downstream resistance. In a traditional back bar (23 mm internal diameter system) with the vaporizers switched off, the wide bore of the gas passages offers minimal flow resistance and so the back bar pressure developed at conventional flow rates (5–10 l min–1) is marginally above atmospheric pressure. However, many modern back bars have narrow bore (8 mm) gas passages, which increase flow resistance and thus back-pressure on the flowmeters. The addition of high-resistance vaporizers and minute volume divider ventilators, which cause a build-up of pressure in the fresh gas flow (see Chapter 9, Automatic ventilators), increases back bar pressures. Table 4.1 shows typical back bar pressures developed and percentage changes in flowmeter settings with the ‘Selectatec’ back bar with and without a high-resistance vaporizer fitted. It should be noted that the small decreases in the flowmeter indications produced does not mean a decrease in the flow of gas to a patient. It is merely that the gas is compressed at the higher pressures and subsequently re-expands downstream when the various resistances have been overcome. Readjustment of the flowmeters to the original settings following an induced pressure rise would therefore be inappropriate.

Oxygen failure warning devices

These were first introduced in the 1950s as a response to the problems of unobserved emptying of oxygen cylinders. However, early models could be unreliable as the battery-powered part of the alarm could be switched off or the battery could be exhausted or missing. The gas-powered part, which relied on nitrous oxide, could also be switched off or fail simultaneously with the oxygen (in which case the alarm would also not work).

The Ritchie whistle

The Ritchie whistle was introduced in the mid-1960s and forms the basis for most current oxygen failure devices. It was the first device to rely exclusively on the failing oxygen supply for its power. Figure 4.24 shows an oxygen failure warning device incorporating a Ritchie whistle marketed at one time by Ohmeda and still present on older machines in service.

The alarm is powered by an oxygen supply at a pressure of 420 kPa (60 psi) in the UK, which is tapped from the oxygen pipework upstream of the flowmeter block. This enters the alarm inlet valve and pressurizes the rolling diaphragm, opening the anaesthetic cut-off valve, and closing the air inspiratory valve and the port to the oxygen failure whistle. Anaesthetic gasses may then pass freely through this device, which is now at standby. The valve is kept in this position by the pressure of the oxygen supply opposing the force of the magnet and the return spring.

Decreasing pressure in the oxygen supply to the flowmeter block activates the valve, permitting a flow of oxygen (via the restrictor) to operate the oxygen failure whistle. The whistle sounds continuously until the oxygen pressure has fallen to approximately 40.5 kPa (6 psi). At a pressure of approximately 200 kPa (30 psi) the force of the magnet keeper return spring and the magnet causes the anaesthetic gasses cut-off valve to be closed, cutting off the supply of anaesthetic gasses to the patient. At the same time the spring load on the air inspiratory valve is released, allowing the patient to inspire room air. Whenever the patient inhales, the inspiratory air whistle sounds.

With the anaesthetic gasses cut-off valve closed, the now potentially hypoxic gas from the flowmeter block vents to the atmosphere through the pressure-relief valve on the back bar.

Current oxygen failure warning devices

BS EN 740:1999 and EN ISO 60601-2-13:2006, its replacement, stipulate that anaesthetic workstations in use with any gasses containing less than 21% premixed oxygen content (e.g. pure nitrous oxide or carbon dioxide) shall be operated with a gas cut-off device. This gas cut-off device must either:

Also ‘the gas cut off device shall not be activated before the oxygen supply failure alarm’, and ‘the sole means of resetting the gas cut-off device shall be restoration of the oxygen supply pressure to a level above that at which the device is activated’.

A gas-powered auditory alarm signal for oxygen failure is required to be of at least 7 s duration and where the alarm signal is gas powered (as opposed to electrically generated) ‘the energy required to operate it shall be derived from the oxygen supply pressure’.

Figure 4.25 shows a schematic diagram of the pneumatic arrangement for an alarm and shut off system that satisfies current standards.

Auxiliary gas sockets

Anaesthetic machines may now be fitted with mini-Schrader gas sockets (Fig. 4.26), but only for air or oxygen. These may be used to power devices such as ventilators, gas injection systems for bronchoscopy, and suction units. The sockets should be permanently and legibly marked for their specific gasses (air or oxygen) and their working pressure of 400 kPa approximately (in the UK).

Ventilators

Automatic ventilators, including their classification and fundamental principles, are discussed specifically in Chapter 9. Ventilators for use in the Intensive Care Unit (ICU) are further considered in Chapter 10.

From the point of view of the anaesthetic workstation, ventilators have developed significantly even in the last decade. Whereas once-simple mechanical minute volume dividers placed on the anaesthetic machine were the norm, with a few adventurous manufacturers installing pneumatically driven bag squeezers or intermittent blowers, the modern anaesthetic ventilator is now akin to an ICU ventilator.

Over the past few years, software driven ventilators have become standard, with manufacturers able to offer a variety of ventilatory modes including pressure-controlled ventilation, synchronized ventilation and pressure-supported spontaneous ventilation as optional extras with the machine’s in-built ventilator. This flexibility is largely a function of the sophisticated electronic control of the proportional flow valve (see below).

In order to fully separate the gasses of the pneumatically driven ventilator used by most manufacturers (there are exceptions such as the Dräger Primus and Zeus below) from the respiratory gasses of the patient, the enclosed bellows arrangement with a rising bellows is almost ubiquitous. Chapter 9 gives a detailed overview of ventilators with specific reference to the ‘bag squeezer’ type ventilators seen in modern anaesthetic workstations. The Blease900 Series ventilator (Spacelabs Healthcare) is described in detail in that chapter and gives an insight into the modern ventilators used in many anaesthesia machines.

Some of the hardware for such ventilators is briefly described in the paragraphs that follow here. Significant variations in design of anaesthesia workstation ventilator are described in the latter part of this chapter under the individual machines, in order to give a comprehensive picture of the devices available.

Proportional flow valves

The heart of the modern ventilator is the proportional flow valve. Proportional valves are increasingly also seen in the control of gas flow within the patient gas circuits. This type of valve allows extremely accurate and rapid control of the flow of gas from a high-pressure source. Whereas a simple solenoid valve can oscillate rapidly between on and off positions, the proportional valve is so termed because the excursion of the solenoid (and opening of the attached valve) is proportional to the voltage applied across it (Fig. 4.27). Fig. 4.28 shows a typical proportional valve. Such a valve typically allows flow rates up to 130 l min–1 with a maximal response time of less than 100 ms. In ventilators the valve is usually placed immediately downstream of a secondary regulator which supplies the drive gas to the valve at a pressure of about 2.3 bar. Manufacturers set this pressure somewhat below the minimum pressure that may be expected from gas pipelines in order to have a non-fluctuating supply pressure to the valve so that pressure/flow characteristics are predictable for the flow controller algorithm. ITU ventilators may have larger, more sophisticated proportional valves with an order of magnitude swifter response times. Massive flows can be rapidly generated on patient demand, even allowing almost seamless pressure support of spontaneous patient breathing. Downstream flow and pressure sensing permits feedback control of the flow from the valve via the microprocessor control system.

Control of such valves is accurate enough to permit positive end-expiratory pressure (PEEP) to be applied in some ventilators simply by allowing a bias flow through the valve during expiration. Sufficient flow, controlled by a feedback loop, is allowed to pressurize the bellows and expiratory (pop off) valve in the bellows housing to give the desired level of PEEP.

Some systems, such as the Dräger E series ventilators, use a separate or second proportional valve to control a lower pressure gas flow from which a side arm is used to pressurize the machine side of an expiratory valve for control of inspiration and PEEP or continuous positive airway pressure (CPAP) (Fig. 4.29). Alternatively this proportional valve can be of a type that operates an actuator directly onto the leaflet of the ventilator inspiratory/expiratory control valve (Fig 4.30). (See also Figs 9.8 and 9.9, solenoid driven proportional flow valve for low-pressure gas.) Note, comparing figures 4.28 and 4.30, that the valves that manage low pressure gas flows have very much larger apertures.

Integral breathing systems

Concerns about economy in the use of volatile anaesthetic agents and gasses, for reasons of both cost and atmospheric pollution, coupled with the heat and moisture retaining properties of the circle system, have ensured that the circle has become an integral part of the modern anaesthetic workstation.

The need to both integrate the breathing system into an ergonomic design and allow sterilization of patient gas pathways, can produce a labarynthine system with multiple parts, valves and microswitches to sense the position and function of levers and detachable components (Fig. 4.31). That in spite of such numerous parts, many of these machines cannot be misassembled and do not leak, is a testament to good engineering design. However, the potential for problems to arise in such complex devices must always be borne in mind and it is advocated that a self-inflating bag and alternative source of oxygen is always readily available (see Pre-use check below). A ‘top circuit’, such as a Mapleson C or D for attachment to the common gas outlet in times of crisis and confusion, is also extremely useful.

The water generated by the circle absorber system is beneficial in moisturizing the inspired patient gasses, but poses a problem for designers of anaesthesia machines particularly with the increasing use of low flow anaesthesia. Rain out or condensation of this moisture in the system can interfere with the function of the valves and flowmetering within these systems. Particular provision must be made for this, and the issue is tackled differently in the various machines by the manufacturers. This may be the use of heated patient circuit plates as in the Dräger Primus (Fig 4.32), or the use of an additional specific condenser arrangement as in the GE Healthcare Aisys (Fig. 4.33). Here this approach is coupled with flowmeters on the circle system that are modified so that water accumulation is less likely to interfere with the function of the flap valve of the differential pressure variable orifice flowmeters. In the Aestiva also by GE Healthcare the point of condensate collection is at the bottom of the absorber assembly and a drain plug is placed there (Fig. 4.34). This is a frequent source of a breathing system leak that is difficult to trace as it is not obvious when this drain plug is open.

Ergonomics

Ergonomics is the study of the efficiency of persons in their working environment and human factors engineering is the design and development of equipment to improve the ergonomics of a task. This has the effect of making the working environment not only more pleasant, but also less tiring and less stressful, which should lead to increased safety. The conventional pneumatic anaesthetic machine ‘just grew’ and there has been little attempt in the past to specifically consider ergonomics. Nonetheless, some design endpoints, reached after a long journey of reducing error and set in current standards, such as those specifying the stand out position and shape of the oxygen flowmeter control knob (together with attendant guards to prevent accidental resetting), exemplify ergonomics in practice.

Given the many demands made of the modern workstation, as detailed above, there has to be far greater consideration given to ergonomics at the design stage. Sections of the machine should have clearly defined task orientations with tasks or modalities not divided across different areas of the machine. Modular approaches to the workstation are particularly prone to having various components fighting one another. The execution of multiple linked manoeuvres to achieve a single functional change in the machine settings (e.g. having to alter several switches to go from spontaneous to controlled ventilation) is an example of poor design. This is clearly more error prone, particularly under stressful conditions, than having a single lever and can leave the patient at risk (here apnoeic). The ‘Feng shui,’ to misappropriate a term from Chinese culture, has to be right. A busy-looking machine, where it is not possible to tell immediately where the pipes are coming from and going to, is an error-prone device.

By contrast, a single item of good ergonomic design sometimes does more to sell a machine than a host of technological advances directed at greater accuracy. In an operating theatre, which may be used for several surgical specialties, the value of features such as a foot-operated single break lever which renders the machine easily mobile on its castors should not be underestimated. The ability to have the machine controls and the patient’s airway all within an easy arc of reach for the anaesthetist can ultimately affect safety and the ease with which a critical incident is dealt with. For similar reasons, the back of the workstation (in particular, the flexible pipeline and electrical cables) should be treated with equal respect and should not be allowed to resemble an explosion in a souk.3

Implicit in the concept of ergonomics is that in a well-designed machine controls and functions are intuitive and it is possible for a new user to quickly learn how to work the device. Militating against this is the desire of manufacturers, particularly where ventilators are concerned, to offer something extra, if only in name.

The critical incident (see also Chapter 29)

The interaction between anaesthetist, anaesthesia machine and patient may be seen as a closed-loop control system4 (Fig. 4.35): with the situation where one or more components of the control loop behave unpredictably, described as a critical incident.

Under adverse conditions the chance of injury to the patient increases with time, as shown in Fig. 4.36. There is a time delay before a problem is noticed by the anaesthetist and the cause identified. Another delay occurs before the problem is corrected, after which there should be a recovery to safe conditions if the correction is made early enough. Excessive delay in noticing the problem or in its correction may lead to permanent injury.

The reliability of the human for constant vigilance over long periods of time is questionable and the ability to make decisions when bombarded with multiple sensory inputs is sorely put to the test. Alarm systems should be designed to allow for as much time as possible to correct a problem before injury begins. Examination of Figure 4.36 shows that this may be accomplished by minimizing the pre-alarm period and making it clear to the anaesthetist what the problem is and its level of urgency. Research has shown that intelligent alarm systems which integrate and prioritize multiple alarm conditions can lead to a more rapid and consistent rectification of adverse incidents.5

The further along the system (e.g. from the gas and electricity supplies to the patient) that a parameter is monitored (Fig. 4.37), the greater the delay before the alarm is sounded and the greater the number of possible causes of that particular problem. For example, if the oxygen supply fails, the oxygen supply alarm would sound immediately. Some seconds later, depending on the fresh gas flow into the breathing attachment, the inspired oxygen monitor alarm would become active. However, it may be more than a minute before the saturation, as indicated by a pulse oximeter, would fall below the critical level. Furthermore, the causes of a drop in SpO2 are numerous compared with the causes of the sounding of the oxygen supply pressure alarm. In this scenario, assuming multiple monitoring points of anaesthesia system and patient, an intelligent alarm system would assimilate the multiple alarm conditions and prioritize the oxygen supply failure, hence leading to the most rapid resolution of the incident.

Alarms

Alarms do not necessarily refer to emergencies, but may indicate abnormal situations that may or may not have the potential to become emergencies. Given the number of different parameters surveyed by the workstation monitors, there clearly has to be some system of prioritizing alarms to allow sensible signalling in multiple alarm conditions. Alarm conditions are, therefore, given a hierarchy from advisory (requiring awareness) to caution (requiring a prompt response) and warning (requiring immediate response). At any time, the condition with the highest priority is preferentially displayed. Ideally an audible warning differentiating between these three levels draws the anaesthetist’s attention to a visual indication of what the problem is. Latching of alarms means that even if the condition leading to the alarm is resolved, the alarm continues to sound until it is acknowledged and reset. Accepted standards give minimum alarm hierarchies for various parameters and state those that can and cannot be disabled.

Much research has been done on alarms,6 alarm characteristics and those features that control the perceived urgency, namely: frequency composition, repetition rate, amplitude, and harmonic relation of the frequency components. The urgency of the alarm must be balanced against its liability to distract the target’s concentration during critical periods, and the possible nuisance effect from ‘false alarms’, as well as its effect on non-target audience (e.g. patient or surgeon). This is not an easy task; additionally, an alarm perceived as excessively intrusive may be disabled by the anaesthetist. Although the BSI and ISO publish clear standards for alarms (BS EN ISO 9703–3:1998), significant latitude is still allowed to manufacturers and even with standards compatible alarm structures it is argued that the current alarms in many popular machines are inappropriate in terms of conveying the correct urgency.7 The 9703 series of standards was withdrawn in 2004. Ideally, however, ultimately alarm signals should be identical across manufacturers for any given modality of monitoring or item of equipment. In any case, it is perhaps time manufacturers revisited this subject.

Nonetheless, the quality of modern monitoring equipment available, as well as the ease and flexibility of operator setting of alarm limits, means that the practice of disabling alarms (rather than setting alarm parameters to prevent inappropriate alarm triggering) is no longer acceptable. By the same token, alarms should not be allowed to continually sound (often a feature of inadequate implied urgency) when there is no perceived problem: this leads to habituation to the alarm sound and ultimately failure to react to appropriate alarms.

Pre-use check

It is mandatory to check the correct functioning of anaesthetic equipment before use. The Association of Anaesthetists of Great Britain and Ireland (AAGBI) publishes a ‘Checklist for Anaesthetic Equipment’ to assist in allowing a comprehensive and systematic check of equipment (Table 4.2). The most recent iteration of this, in 2004,8 recognizes the introduction of microprocessor controlled technology into anaesthetic workstations and attempts not to reduplicate the self-test cycle that modern workstations undergo on start-up. It also stresses the importance of familiarity with these potentially complex pieces of machinery and hence the need for a formal ‘induction’ onto the machine. Also noteworthy is the requirement that a log should be kept of the completion of a pre-use check according to both the requirements of the manufacturer and the AAGBI checklist.

Table 4.2 AAGBI checklist for anaesthetic equipment (with permission from AAGBI)

THE ASSSOCIATION OF ANAESTHETISTS OF GREAT BRITAIN AND IRELAND
CHECKLIST FOR ANAESTHETIC EQUIPMENT 2004
The following checks should be made prior to each operating session.
In addition, checks 2, 6 and 9 (Monitoring, Breathing System and Ancillary Equipment) should be made prior to each new patient during a session.

1. Check that the anaesthetic machine is connected to the electricity supply (if appropriate) and switched on. Note: Some anaesthetic workstations may enter an integral self-test programme when switched on; those functions tested by such a programme need not be retested.

2. Check that all monitoring devices, in particular the oxygen analyzer, pulse oximeter and capnograph, are functioning and have appropriate alarm limits.

(Some monitors need to be in stand-by mode to avoid unnecessary alarms before being connected to the patient.)

3. Check with a ‘tug test’ that each pipeline is correctly inserted into the appropriate gas supply terminal. Note: Carbon dioxide cylinders should not be present on the anaesthetic machine unless requested by the anaesthetist. A blanking plug should be fitted to any empty cylinder yoke.

4. Check the operation of flowmeters (where fitted).

5. Check the vaporizer(s):

6. Check the breathing system to be employed.

Note: A new single-use bacterial/viral filter and angle-piece/catheter mount must be used for each patient. Packaging should not be removed until point of use.

7. Check that the ventilator is configured appropriately for its intended use.

8. Check that the anaesthetic gas scavenging system is switched on and is functioning correctly.

9. Check that all ancillary equipment which may be needed is present and working.

10. Check that an alternative means to ventilate the patient is immediately available (e.g. self-inflating bag and oxygen cylinder).

11. Recording.

This checklist is an abbreviated version of the Association of Anaesthetists publication ‘Checking Anaesthetic Equipment 3 2004’

(endorsed by the Chief Medical Officer and the Royal College of Anaesthetists).

With all machines and, perhaps, even more so with electronically controlled workstations, consideration must be given to the possibility that the machine will fail to deliver any or adequate flows of gas. For this reason it is imperative to check that an alternative oxygen supply and means of ventilation, such as a self-inflating bag, are readily available and functional.

An abbreviated description of the AAGBI checking procedure is produced as a laminated sheet for attachment to each anaesthetic machine. This is reproduced below.

Specific machines

By considering some additional aspects of just a few specific machines, it is possible to achieve a perspective on the scope of design of the modern workstations currently available. Also, an understanding of the workings of any one machine potentially gives insight into significant issues and features of these devices in general. Five machines are therefore considered separately below. When compared with each other it is interesting to observe their differing use of technology and the disparate focus of their respective designers. It will be interesting to see, over the next few years, which approach predominates and where the application of technology will prove most effective. Certainly, electronic control of the machine does not yet dominate, although it appears to be gaining more widespread acceptance than 5 years ago.

A number of manufacturers still produce simple pneumatic machines with no electronic components or integral breathing systems and there is clearly a role for such equipment. They are reliable, need minimal maintenance and are low cost and admittedly simpler to operate. They predominate in areas where non-anaesthetists may use them for resuscitation and in areas where space may be at a premium or other constraints operate, such as anaesthetic induction areas. Their design conforms to the principles outlined above under ‘The anaesthetic delivery system’; certainly in the UK there should no longer be machines available anywhere capable of delivering an hypoxic mixture.

The following paragraphs are not intended as a critique or assessment of the machines. Features and failures are highlighted purely to make the reader aware of issues that may be pertinent to any device being considered. The purpose of anaesthetic machines is ultimately quite simple – the safe delivery of drugs. Increasing familiarity with a machine can therefore only reveal its inadequacies.

(Datex-Ohmeda) Aestiva/5, GE Healthcare

The Aestiva/5, and its family of machines launched in 1998, has been a very successful design of anaesthetic workstation (Fig. 4.38). It is, in all respects, a traditional pneumatic machine. There is a built-in circle system and a software-driven, pneumatically powered ventilator using the ‘enclosed bellows’ arrangement to isolate respiratory and driving gasses. The ventilator type is briefly described above and specifically in detail in Chapter 9 (Datex-Ohmeda 7900). Conventional vaporizers are mounted on the back bar. Hypoxic mixture prevention is by use of the Ohmeda Link 25 system (see Fig. 4.17). The CGO, as opposed to the integral circle breathing system, is selected by a lever discretely positioned to the side of the absorber.

Its popularity owes more to good ergonomic design than the use of advanced technology. Without doubt, much of this is due to the long-established Datex-Ohmeda AS/3 design of patient monitor. This monitor has hot swappable individual modules for an extensive number of parameters and benefits from a flexible and well laid out display and intuitive operating menu structure. This monitor is neatly housed within the Aestiva with a remote flat panel display which can be mounted on the swing arm of the machine to sit above or below the control panel of the ventilator. Depending on the configuration requested, the machine can offer a significant amount of flat storage or working surfaces and drawers. Use of a single, foot-operated brake lever renders the machine freely mobile, allowing easy positioning of machine for access to the patient in any operating room set-up. The overall appearance of the machine is unfussy with clearly defined instrument clusters.

Those new to the machine should be aware that the low-urgency ventilator panel alarms, such as the advisory alarm for selection of the auxiliary common gas outlet, are too easily ignored. One area where the machine would benefit from a more intelligent alarm structure is in the linking of respiration detected on the sensors of the integral circle system to the position of the auxiliary common gas outlet selection lever. Currently, with no increase in alarm urgency, a patient can breathe spontaneously on the circle system with volumes monitored at the circle displayed on the ventilator panel, whilst anaesthetic gasses are delivered elsewhere.

(Datex-Ohmeda) ADU, GE Healthcare

First released in 1995 (‘ADU 95’) and with a subsequent ‘ADU 98’, this is still a striking-looking machine by virtue of the absence of traditional rotameters and vaporizers and the presence of twin flat panel displays for patient monitoring and control and monitoring of the pneumatic systems (Fig. 4.39). GE Healthcare (who took over Datex-Ohmeda) ceased production of this device in February 2010 with over 11 000 units having been put into service worldwide.

The ADU is essentially a modular system and comprises:

The ventilator and fresh gas control units have their own microprocessor controls which communicate through the central electronic unit. A number of features of the ADU stand out for individual consideration (Fig. 4.40).

In spite of the absence of traditional flowmeters, gas flow is set by the operator using standard needle valves. An electronic switch selects air or N2O as the ‘side gas’. Electronic flow measurement across a laminar flow restrictor for both oxygen and the side gas ensures a minimum 25% oxygen concentration by controlling a proportional valve downstream of the N2O needle valve when N2O is selected. Gas flows are shown as pictograms on the user interface which also has a comm wheel for selecting and setting ventilator parameters.

The ventilator is a sophisticated microprocessor controlled pneumatically driven (air or oxygen) design employing a number of proportional valves for individual control of inspiratory flow, expiratory valve and PEEP valve. Pressure and flow are measured at a number of points in the pneumatic system to allow close control of respiration. A single lever on the bellows block selects between bellows or reservoir bag and APL valve and relays via a sensing microswitch to switch on the ventilator.

At the time of its inception it was unique in its electronic control of agent concentration. The Aladin cassette system none the less relies on the conventional approach of saturation of a proportion of the fresh gas flow by passage through a vaporizing chamber. Here though, when the desired agent concentration is selected on the machine, a proportional valve controls the flow of gas through the vaporizer. By comparing the bypass flow measurement within the machine with the vaporizer flow measurement, the proportional valve is set to achieve the desired target (Fig. 4.40). The system is described in greater detail in Chapter 3. Note that in the ADU feedback control of the agent concentration relies on calculations of flow and does not involve measurement of agent concentration.

The patient monitoring unit of the ADU will be familiar to many as the Datex-Ohmeda AS/3 or S/5 and is a separate modular monitor with no linkage to the control unit of the ADU.

Dräger Primus

The Dräger Primus, available since 2003 (Fig. 4.41), represented another departure in design. Its main distinguishing feature is the electronic fresh gas mixer.

image

Figure 4.41 The Dräger Primus.

Photo courtesy of Dräger Medical UK.

Here, fresh gas is mixed entirely by electronically controlled valves according to the desired total flow and oxygen concentration. The ADU, for comparison, utilizes mechanical needle valves set by the operator with subsequent electronic adjustment to the flow of N2O. In the Primus the operator selects air or N2O as the carrier gas, and sets a total flow and the desired oxygen concentration (Fig. 4.42). A gas controller unit under feedback control sequentially opens high-speed solenoid valves to allow oxygen and the secondary gas to fill the mixed gas reservoir at the desired concentration. A proportional valve distal to this controls total flow into the pneumatic system. With this form of microprocessor control it is possible to have preset defaults for minimum oxygen concentration and this may be linked to the total set gas flow such that at total flows below 1 l min–1 the machine will maintain a minimum oxygen flow of 250 ml min–1. Gas flows are shown as virtual flowmeters on the control panel.

In case of failure of the gas mixing unit, a graduated oxygen control knob can be deployed delivering gas into the circuit via the traditional calibrated vaporizer.

The Primus, in common with some other machines in the Dräger range, uses an electrically driven piston ventilator (Fig. 4.43) capable of generating flows up to 180 l min–1 with a tidal volume up to 1400 ml. The ventilator itself is further discussed in Chapter 9. By arranging fresh gas inflow into the circle on the expiratory side of the ventilator circuit (before the ventilator) and separating them using a non-return valve, the system achieves fresh flow gas decoupling of the delivered tidal volume. An incremental encoder comprising a perforated disk attached to the drive spindle of the piston gives precise measurement of piston displacement. Measurement of the expired gas flow from the patient allows close matching of the piston’s downstroke so as not to generate negative end expiratory pressure whilst also not entraining gas from outside the circuit. This is necessary for the preservation of low fresh gas flows. Gas flow measurement in the patient circuit uses hot wire anemometry. The reservoir bag is in circuit and functional during mechanical ventilation, taking up excess gas flows and also providing a buffer during the downstroke of the piston ventilator (Fig. 4.44). The expiratory control valve uses a proportional valve as discussed above (Fig. 4.29). The software driven ‘E Ventilator’ is also able to ventilate in pressure control and assisted spontaneous breathing modes.

Dräger Zeus

The Zeus, launched initially in 2003 and in the UK in 2005, represents Dräger’s most advanced anaesthesia workstation to date and employs a number of novel approaches in its electronic control of gas delivery and ventilation that mark it out from other machines currently available. The package as a whole consequently has few of the visual aspects that would normally identify an anaesthetic machine (Fig. 4.45). Ergonomics is addressed by a central brake pedal, 180° rotating capability of the display panel arm and push through drawers allowing the machine to be used from either side. The outstanding features of the device are its automated control of patient gas composition using a choice of two different control algorithms and its use of a novel miniature turbine within the breathing system to power patient gas circulation and ventilation. The Zeus includes the following components:

Like the Aisys below, the only direct mechanical controls are the emergency oxygen flush button (here duplicated on the opposite side of the machine), a deployable back-up oxygen needle valve control, and an additional O2 flowmeter for supplemental oxygen. These sections of the machine do not need an electrical supply to be operational. The machine is otherwise entirely controlled through a touch-sensitive flat panel display.

Gasses are delivered to a digital gas mixer from secondary regulators at 2.4 bar. Gas mixing for the fresh gas flow into the patient circuit is then achieved by two banks of five digital switching valves (solenoids): one bank for control of oxygen and the other used for either air or nitrous oxide. Volatile admixture is from the DIVA unit (Direct Injection of Volatile Agent, described in detail in Chapter 3). This is an air-pressurized, electronically controlled, heated, measured flow vaporizer. This preceding arrangement for control of the gas mixture, along with two parallel in-built gas analysis modules, allows software-driven automated control of inspired oxygen and end tidal volatile agent concentration as well as the fresh gas flow (FGF) rates in the appropriate control modes. The user, for example, sets the desired end tidal concentration of volatile agent; the agent concentration in the FGF into the circle system is then controlled by the machine to achieve and maintain that target concentration in expired patient gas. Labelled by the manufacturer as ‘Target Controlled Anaesthesia’, it allows something akin to the ‘effect site Target Controlled Infusion’ of intravenous drugs for volatile agents. In ‘auto control’ mode different algorithms can be made to operate to provide both rapid adjustment of gas composition and economical use of volatile agents in the ‘uptake mode’ where oxygen concentration is only adjusted down by patient uptake rather than new gas delivery. There is not room here to elucidate in any detail the specifics of these automatic modes.

A small turbine (Fig. 4.46) generates the pressure required for ventilation and to improve the mixing of gasses in the patient circuit it also provides a circulatory flow during spontaneous respiration. In operation the peak inspiratory pressure that can be generated is about 50 cm H2O. Fig. 4.47 shows how this, in combination with a proportional valve that closes fully or partially and the hot wire anemometry flow sensors placed in the patient circuit, can effect all modes of ventilation and PEEP.

GE Healthcare, Aisys

The Aisys (coined form Anaesthesia Integrated System) launched in the UK in 2006 is this manufacturer’s fully electronically controlled anaesthetic workstation (Fig. 4.1). In contrast to the Datex-Ohmeda ADU (see above), this model uses electronic control of gas flow into the patient circuit, doing away with the needle valves seen in the ADU. It is in all other respects a fairly conventional design. The vaporizer module uses identical technology to the ADU and the ventilator assembly is the conventional proportional valve driven enclosed bellows system of the Datex-Ohmeda 7900 series. Unlike the externally connected breathing system of the ADU, however, the circle breathing system here is very much integral to the machine. Gas flow into this circle system is such that for use with other breathing systems (e.g. Mapleson A or D), by selecting a non-circle mode on the machine control panel the inspiratory outlet of the ‘circle’ may be used as a common gas outlet (CGO). The machine may also be optioned with a switchable separate CGO as in the Aestiva.

Fig. 4.48 shows the pneumatic system of the Aisys. The emergency oxygen flush button and the auxiliary O2 flowmeter are direct mechanical systems and do not require the machine to be powered on. The alternate O2 flowmeter is in series with the master on/off switch and is provided as a parallel back-up system in case of failure of the display unit or electronic control of the gas mixer when the workstation is switched on and functional (Fig. 4.49). Under such circumstances it should deploy automatically and allow the manual control of oxygen into the patient circuit. Depending on the source of the problem, it is possible that electronic control of gas flow to the vaporizer is maintained and hence volatile agents can still be administered, though of course there would be no second or carrier gas.

An attraction of electronic gas flow control is its flexibility, demonstrated by an additional feature made available in 2010 that simply requires a software upgrade to the CPU of the workstation and a small change to the respiratory gas module of the patient monitor. End tidal control of oxygen and volatile agent concentration is now possible in this device by creating a feedback loop between the patient gas monitoring module and the vaporizer and gas flow control system. The algorithm controlling this function adjusts the fresh gas-flow composition to rapidly achieve the desired concentration in the exhaled patient gas.