Staging, Classification, and Oncologic Approaches for Metastatic Tumors Involving the Spine

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Chapter 109 Staging, Classification, and Oncologic Approaches for Metastatic Tumors Involving the Spine

The early diagnosis and management of metastatic spine tumors is essential to reducing pain, preserving or improving neurologic function, and improving quality of life. The three primary treatment modalities are radiation therapy (RT), surgery, and chemotherapy. Although these treatment modalities are all essential for treating metastatic spine tumors, prospective trials and prognostic guidelines have yet to definitively delineate the role of any single modality as first-line therapy. The evolution of advanced radiation techniques, such as image-guided (intensity-modulated) radiation therapy (IGRT), and noninvasive percutaneous cement augmentation procedures have added significantly to the armamentarium in the treatment of metastatic spine tumors and increased the complexity of decision making for this patient population. One recent randomized prospective study identified a subpopulation of patients who may benefit from surgery.1 Although decision making for an individual patient remains largely based on institutional experience and the individual preferences of the treating physician,23 clinical data and new decision frameworks can help guide therapy.

Decision Frameworks

Traditionally, assessment systems such as the Tomita and Tokuhashi scoring systems have been used to derive treatment for metastatic spine tumors.2 The Tomita score takes into consideration the grade of malignancy and visceral and bone metastases. A low score indicates a good prognosis. The Tokuhashi scoring system is useful for predicting survival and evaluates performance status, tumor histology, neurologic impairment, and the numbers of bone, vertebral body, and visceral metastases.35 These scoring systems were useful and validated for surgical outcomes, but the evolution of stereotactic radiosurgery has dramatically changed tumoral responses, making the surgical recommendations from these systems somewhat outdated.

At Memorial Sloan-Kettering Cancer Center (MSKCC), treatment decisions for patients with spine tumors are driven by a conceptual framework referred to as NOMS, which incorporates four fundamental considerations: neurologic (N), oncologic (O), mechanical (M), and systemic (S) disease.6 Neurologic considerations include the presence of myelopathy or functional radiculopathy, as well as the degree of radiographic epidural spinal cord compression. Oncologic issues primarily reflect the ability to achieve local, durable tumor control, and, thus, reflect the radiosensitivity and/or chemosensitivity of the tumor. Mechanical instability is a separate assessment that evaluates the stability of the spine based on the presence of pathologic fractures, lytic bone destruction, deformity, and the presence of movement-related pain. Finally, the extent of systemic disease and medical comorbidities reflect the patient’s ability to tolerate an operation, radiation, or chemotherapy and the patient’s overall prognosis.

In general, the NOMS-based analysis is not intended as an algorithmic approach to patient care. Rather, this classification scheme offers a framework for discussion at multimodality treatment conferences (Fig. 109-1). Details regarding each of these four considerations are discussed later in the chapter.

Presentation

Back pain, the most common presenting symptom in patients with metastatic tumor to the bone or epidural space, often precedes the development of other neurologic symptoms by weeks or months. Back pain in a cancer patient is metastatic disease until otherwise proven. Two distinct types of back pain are encountered in patients with spine tumors: (1) biologic (i.e., tumor-related) pain and (2) mechanical pain.7 Biologic pain is the most common presenting symptom in metastatic cancer patients. This pain syndrome is predominantly nocturnal or early morning pain that generally improves with activity during the day. A variety of causes have been proposed, including periosteal irritation, stimulation of intraosseous nerves, and increased pressure or mass effect from tumor tissue in the bone.8 The likely genesis of biologic pain reflects the diurnal variation in endogenous steroid secretion from the adrenal gland. At night, steroid production is reduced, resulting in increased inflammatory pain caused by cytokines released by the tumor. During the day, steroid levels rise, eliminating this biologic pain. This inflammatory component of biologic pain generally responds to the administration of low-dose steroids (e.g., dexamethasone [Decadron] 4 mg three times daily). Definitive treatment of the underlying tumor with radiation or surgery often relieves this pain. Recurrence of biologic pain following treatment may be a harbinger of locally recurrent tumor.

Mechanical pain results from a structural abnormality of the spine, such as a lytic destruction of the vertebral body, resulting in instability (Fig. 109-2). Clinical symptoms and radiographic correlation are important for establishing the diagnosis of instability. As opposed to biologic pain, patients with mechanical instability present with pain that is worse with movement and that is referable to the level of spinal involvement. For example, although pathologic fractures of the atlantoaxial spine may present with severe pain in flexion-extension, they virtually always have a rotational component. In the subaxial cervical spine, mechanical pain is worse with flexion and extension. Counterintuitively, patients with thoracic or thoracolumbar compression fractures often have severe pain when lying flat as opposed to sitting or standing, presumably because of extension of an unstable kyphosis (Fig. 109-3). The most common symptom of instability in the lumbar spine is mechanical radiculopathy. This lumbar pain syndrome results from an axial load narrowing the neural foramen, thus causing compression of the exiting nerve root. Mechanical pain does not typically respond to steroids but may be relieved with narcotics or an external orthosis, pending definitive therapy. Patients with intractable mechanical pain are often considered strong candidates for surgery or percutaneous cement augmentation procedures (Fig. 109-4).

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FIGURE 109-4 Kyphoplasty. Plain radiographs obtained during (A and B) and after (C and D) kyphoplasty procedure for the patient shown in Figure 109-3. A, Lateral plain radiograph showing percutaneous placement of bilateral Jamshidi needles into the pedicles of L1. B, Balloon inflation prior to instilling cement. Anteroposterior (C) and lateral plain radiographs (D) showing bilateral kyphoplasty of T12 and L1. (See also Figs 1093 and 109-5.)

Neurologic signs and symptoms often begin with radiculopathy (nerve root symptoms) and are followed by the development of myelopathy (spinal cord compression). Radiculopathy in the cervical or lumbar spine causes pain or weakness in the classic dermatomal distributions. However, thoracic radiculopathy occurs as bandlike pain at a segmental level. Myelopathy often presents with a pain level secondary to compression of the spinothalamic tracts followed by motor loss related to corticospinal tract involvement. This may be related to the pattern of tumor arising from the vertebral body compressing the anterolateral spinal cord. Loss of proprioception from involvement of the dorsal columns is often a late finding in myelopathy and results in difficulty regaining normal ambulation. Autonomic dysfunction, principally of bowel and bladder, are typically very late findings in myelopathy. The exception is compression at the level of the conus medullaris or diffuse sacral replacement where autonomic dysfunction can be a very early finding. Neurogenic bowel and bladder symptoms are almost universally associated with perineal numbness and are most often painless. In the absence of sensory changes, one should seek other causes for urinary or bowel incontinence, such as narcotics, prostatic hypertrophy, or excessive use of laxatives.

Neurologic testing should not simply focus on sensorimotor function below the level of the lesion. This is important for several reasons. First, these patients often have multiple spine lesions and it is important to determine exactly which ones are contributing to the patient’s symptoms. In addition, it is also important to adequately rule out other causes for symptoms such as brain metastasis or peripheral neuropathy. Any patient with facial weakness or other cranial neuropathies requires cranial imaging prior to surgical intervention for metastatic spine disease. In addition, focal extremity weakness with normal or decreased reflexes may be caused by plexus or peripheral nerve compression as is seen with brachial plexus metastases. Finally, adequate documentation of the patient’s radiographic and neurologic status at the time of presentation is of utmost importance for judging either response or deterioration during the course of treatment.

Staging and Classification

The examination of spinal patients should include a pain assessment, quantitative neurologic score, general performance score, and quality-of-life assessment. Pain assessment can be most readily performed with a visual analogue scale. The score can be converted to reflect mild (0–4), moderate (5–6), and severe (7–10) pain.9 The two most commonly used neurologic scales include the Frankel grading system and the American Spinal Injury Association (ASIA) score10,11(Table 109-1). Both assess motor function, with a score of “E” being normal and “A” being complete paralysis. Performance status reflects ambulation, medical comorbidities, and extent of disease. A patient may have normal motor strength but be unable to ambulate due to loss of proprioception, severe mechanical pain, lower extremity fracture, poor nutritional status, or poor pulmonary function. We have used the Eastern Cooperative Oncology Group (ECOG) performance status as a functional assessment12 (Table 109-2). It is important to include both neurologic and performance status when reviewing outcomes in cancer patients.

TABLE 109-1 ASIA Impairment Scale

Grade Description
A Complete: No motor or sensory function below the level
B Incomplete: Sensory but no motor function
C Incomplete: Some motor function is preserved, but a majority of the muscle groups below the lesion have a grade <3
D Incomplete: Some motor function preserved, but a majority of the muscle groups below the lesion have a grade >3
E Normal sensory and motor function

ASIA, American Spinal Injury Association.

TABLE 109-2 ECOG Performance Status

Grade Description
0 Fully active, able to carry on all predisease performance without restriction
1 Restricted in physically strenuous activity but ambulatory and able to perform light work
2 Ambulatory and capable of all self-care but unable to perform work activities (bedridden <50% of the time)
3 Capable of only limited self-care (bedridden >50% of the time)
4 Completely disabled, not capable of any self-care (bedridden 100% of the time)

ECOG, Eastern Cooperative Oncology Group.

Metastatic tumors to the spine are classified based on numerous features, including histology, location, and pattern of tumor. The most common spine metastases are listed in Table 109-3. These tumors are further classified into relatively radioresistant and radiosensitive groups (Table 109-4), which influences the decision to use radiation as first-line therapy. Tumors may further be divided by the level and extent of spinal element involvement (e.g., vertebral body, dorsal element, or circumferential) and degree of epidural compression (see later discussion). Thorough radiographic imaging is essential for treatment decisions.

TABLE 109-3 Review of Primary Cancers with Spinal Metastases seen at M.D. Anderson Cancer Center, 1984–1994

Primary Site Percentage of All Spine Metastases (n = 11,884)
Breast 30.2
Lung 20.3
Blood 10.2
Prostate 9.6
Urinary tract 4.0
Skin 3.1
Unknown primary 2.9
Colon 1.6
Other 18.1

Adapted from Gokaslan ZL, York JE, Walsh GL, et al: Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 89(4):599–609, 1998.

TABLE 109-4 Radiosensitivity of Various Metastatic Spine Tumors

Sensitivity Tumor Histology
High Lymphoma
Myeloma
Intermediate Breast
Prostate
Low Sarcoma
Renal Cell
Lung
Colon

Imaging

Advances in imaging techniques have improved the sensitivity of detecting spinal metastases and the specificity of differentiating other processes that involve the spine. MRI has revolutionized assessment of metastatic spine tumors, but many imaging modalities, including plain radiographs, bone scan, CT scan, myelogram, and positron emission tomography (PET), play a role in evaluating metastatic spinal tumors. The goal of imaging is to be 100% sensitive and specific in identifying tumor, giving precise anatomic detail, identifying distant metastases, and showing recurrent tumor following the placement of instrumentation. No single imaging modality accomplishes all of these goals, of course, but understanding the advantages and disadvantages of different imaging modalities allows the clinician to better decide patient screening and treatment planning.

Plain radiographs are often ordered as the first test to evaluate the cancer in a patient with new-onset back pain; however, plain films are relatively poor screening tests for metastases (Fig. 109-5). Visualization of a radiolucent defect on plain radiographs typically requires at least 50% destruction of the vertebral body. Additionally, metastatic tumor often infiltrates the bone marrow of the vertebral body without destroying the cortical bone. Compression and burst fractures are readily identified. Plain radiographs can identify sagittal (kyphosis) and coronal (scoliosis) plane deformities in a weight-bearing state, whereas spinal deformities imaged in a supine position by MRI or CT may be reduced and, thus, remain undetected. Dynamic flexion and extension films may be used to detect instability, although in our experience they are rarely necessary and may put the patient at risk for progressive spinal cord injury. Following surgery, plain films are the best imaging modality for assessing spinal alignment and structural integrity of the instrumentation.

Bone scans (using technetium-99m methylene diphosphonate [99mTc-MDP]) are more sensitive than plain radiographs for detecting spinal metastases13 (Fig. 109-6). The advantage of a bone scan is its ability to screen the entire skeleton with a single image. Patients with spinal tumors often have other bone involvement that may be causing symptoms or require intervention. For example, a patient with L2 vertebral body disease causing nerve root compression may have a concomitant, symptomatic tumor in the pelvis, hip, or femur. However, bone scans rely on an osteoblastic reaction or bone deposition to detect spinal metastases so that rapidly progressive, destructive tumors may not be detected.13,14 Bone scans are relatively insensitive for multiple myeloma and tumors confined to the bone marrow and have a low specificity for tumor.14 Fractures, degenerative disease, and benign disorders of the spine (Schmorl nodes, hemangioma) all may be positive. Additionally, paraspinal tumors that enter the epidural space through the neuroforamen can result in back pain and progressive neurologic symptoms that often are not detected on bone scan. In a review by Avrahami et al., 21 out of 40 patients (52%), with previously diagnosed tumor and symptoms referable to the spine had a negative CT and bone scan, but tumor was seen on MRI.15 Frank et al. reviewed a series of 95 patients, 28% of whom had a negative bone scan with MRI scan showing tumor and a discordance rate between the two imaging modalities of 31%.16

Until MRI became widely available, myelogram and CT were the best diagnostic modalities for assessing acute spinal cord compression. Risks associated with myelography, including acute neurologic decompensation in patients with high-grade blocks, have diminished its role.17,18 CT continues to be useful both for assessing the degree of bone destruction and for determining when bone rather than tumor is causing spinal cord compression. For patients who have had spinal reconstruction with placement of metallic instrumentation, including titanium, it may be difficult to obtain accurate images of the spinal canal with MRI, and CT myelogram may be helpful for ruling out recurrent epidural disease and spinal cord compression1921 (Fig. 109-7). Myelography and postmyelogram CT images continue to be used for imaging for these patients. Also, CT myelograms are currently used for radiosurgery treatment planning to specifically identify the location of the spinal cord or cauda equina.22

MRI is the most sensitive and specific modality for imaging spinal metastases. Sagittal screening images of the entire spine reveal bone, epidural, and paraspinal tumor.23 The extent and degree of spinal cord compression can be readily appreciated, especially on T2-weighted images (Table 109-5). Hybrid scans of the brachial or lumbosacral plexus may reveal tumor in patients with extremity weakness that is not entirely related to spinal cord or root involvement. Leptomeningeal metastases and intradural metastases are often well visualized but require the use of contrast agents (gadolinium diethylene triamine pentaacetic acid [Gd-DPTA])24 (Fig. 109-8).

TABLE 109-5 Memorial Sloan-Kettering Cancer Center Epidural Spinal Cord Compression Grading Scale

Grade* Description
0 No subarachnoid space compression
1 Subarachnoid space partially obliterated without spinal cord compression
2 Subarachnoid space partially obliterated with spinal cord compression
3 Subarachnoid space completely obliterated with cord compression

* Determined at level of worst compression.

Common imaging sequences used to evaluate spinal metastases are T1- and T2-weighted MRI.25 Tumor on a T1-weighted image is hypointense relative to the normal marrow signal (Fig. 109-9A) and typically enhances after administration of gadolinium (Fig. 109-9B). The ports from prior spinal radiation can be discerned on T1-weighted images as hyperintense signal change and may assist in making acute therapeutic decisions when radiation port films are not available. Tumor is hyperintense relative to marrow on standard T2-weighted imaging and produces a myelogram effect with cerebrospinal fluid appearing hyperintense (Fig. 109-9C). Unfortunately, using the recently developed timesaving fast-spin echo, T2 techniques may decrease tumor conspicuity. This decreased conspicuity can be compensated for using short-tau inversion recovery (STIR) techniques. STIR images show enhanced contrast between the lipid marrow (hypointense) and tumor (hyperintense)2628 (Fig. 109-9D). They may be the most sensitive screening modality for tumor but give less anatomic detail than standard T1 or fast spin echo T2 images.29 Because of the high rate of multiple noncontiguous lesions, we suggest screening the entire spine with sagittal sequences followed by axial cuts through any areas of abnormality. At our institution, a screening assessment of the entire spine is obtained specifically to evaluate the T1- and T2-weighted STIR images. The degree of compression is based on the axial T2- and/or axial T1-weighted postcontrast images.

The conversion of spine tumor assessment from CT-myelogram to MRIs left a void in describing the degree of spinal cord compression. For instance, no correlate existed on MRI for a complete myelographic block. NOMS decision making is often made based on the neurologic assessment of the degree of spinal cord compression in combination with relative radioresistance of the tumor.6 A recent review by the Spine Oncology Study Group showed greater interrelater and intrarelater reliability using T2-weighted images than with T1-weighted pre- or postcontrast images in the assessment of spinal cord compression.29A The newly revised epidural spinal cord compression (ESCC) grading system assesses tumors on T2-weighted axial images and assigns a score from 0 to 3. Grade 0 indicates tumor within bone only without any involvement of the epidural space. Grade 1 is subarachnoid space impingement by tumor extending from the bone, but no compression or deformation of the spinal cord. For radiosurgery planning purposes, ESCC grade 1 was subdivided into 1a (epidural abutment), 1b (epidural impingement), or 1c (epidural impingement with spinal cord abutment). Grade 2 indicates spinal cord compression and deformation, but spinal fluid is still visualized at the level of compression. Grade 3 is spinal cord compression with obliteration of all cerebrospinal fluid space at the level of cord compression. Grade 3 is the magnetic resonance (MR) radiographic equivalent of a complete block on myelogram (Fig. 109-10;see also Table 109-5).

image

FIGURE 109-10 The epidural spinal cord compression grading scheme described in Table 109-5 is illustrated here with representative axial T2-weighted MRI. Grade 1 is epidural disease without spinal cord compression and is divided into three grades. A, Grade 0—bone involvement only. B, Grade 1a—abutment of the thecal sac. C, Grade 1b—indentation of the thecal sac. D, Grade 1c—abutment of the spinal cord. E, Spinal cord compression or deformation, but cerebrospinal fluid (CSF) is still found at this level. F, Spinal cord compression with obliteration of all CSF space at this level.

Although MRI is an excellent screening tool for metastatic tumor spread to bone, differentiating tumor from osteomyelitis, osteoporotic compression fractures, and previously treated tumor may be difficult. The T1- and T2-signal characteristics are similar in all of these conditions. Osteomyelitis is more likely to cause changes in the end plate and disc space, whereas tumor rarely, if ever, involves the disc space. Based on these imaging characteristics, osteomyelitis can be differentiated from tumor with 97% accuracy.30 Unfortunately, patients with tumor may secondarily become infected, rendering the imaging patterns unreliable in these situations.31

Osteoporotic compression fractures are extremely common in the cancer population and have been differentiated from pathologic fractures with 94% accuracy based on T1-weighted imaging characteristics.32 Osteoporotic fractures are more commonly thoracic, lack signal change, have bandlike abnormality and do not involve the pedicle, or have contour abnormality. Pathologic fractures show homogeneously decreased signal and have convex vertebral contours. Pathologic fractures may involve the pedicles and are more commonly located in the lumbar spine.

Oncologists often rely on imaging changes to determine the efficacy of treatment; however, response to RT or chemotherapy is difficult to assess in bone tumors because of the lack of signal change on MRI. On T1-weighted images, both treated and viable tumors appear hypointense relative to normal marrow signal. In a study of breast cancer patients, only 3% had a reduction in the volume or number of vertebral bodies involved on imaging, and there was no correlation between changes in signal intensity and clinical response to therapy.33 In a palliative care situation, clinical response to therapy (resolution of tumor-related pain) may suffice despite the absence of radiographic change. Therapeutic decisions for some metastatic tumors (e.g., Ewing sarcoma, neuroblastoma, and seminoma) rely on differentiating viable from necrotic tumor. Traditional MRI sequences do not change significantly after treatment. Current investigations are examining the use of MR perfusion to differentiate viable from necrotic tumor.

Recent work has explored the use of 2-[18F] fluoro-2-deoxy-d-glucose (FDG-PET) for differentiating osteoporotic or traumatic fractures from pathologic compression fractures and to determine viability of previously treated bone tumors.3436 Additionally, on T1-weighted images, bone edema may appear hypointense similar to tumor signal and FDG-PET may be useful in directing the biopsy to a specific hypermetabolic site in the vertebral body, thereby increasing the chance of successfully making a diagnosis. Laufer et al. reviewed 82 patients with hematologic and solid tumor malignancies. All patients underwent biopsy within 6 weeks of their PET scan. The mean standard uptake values (SUVs) were 7.1 for malignant tumors compared with 2.1 for benign lesions (p < .02). A 100% concordance was identified with an SUV cutoff of 2 in solid tumor malignancies with lytic or mixed lytic sclerotic bone involvement. Sclerotic bone lesions often have low SUVs secondary to the paucity of tumor cell, and PET is less predictive in differentiating osteoblastic tumors from benign pathology.37 Similar work relating SUVs to the presence of tumor found a threshold cutoff of 2.5 that predicted tumor.38 Improved diagnostic accuracy can be achieved by combining PET with CT since 18(F)-FDG PET/CT has a greater specificity for detecting spine metastases than either 18(F)-FDG PET or CT alone39 (Fig. 109-11). Other radionuclide scans may be helpful for screening specific tumor types, including iodine-109 scans for papillary thyroid cancer, meta-iodobenzylguanidine (MIBG) scans for neuroblastoma, and somatostatin scans for neuroendocrine tumors.

Metabolic and Physiologic Issues

Cancer patients are prone to numerous metabolic and physiologic abnormalities either as the result of their disease process or due to side effects of previous treatments. Therefore, assessment for many of these abnormalities must be performed prior to considering treatment. Hypercalcemia occurs in approximately 10% to 20% of all cancer patients, with lung and breast tumors being the most common primaries.40 The pathophysiologic abnormalities that lead to this condition are believed to be secondary to the multifactorial effects of increased bone turnover and increased calcium reabsorption in the proximal renal tubules. However, immobilization and dehydration have also been shown to be contributing factors, especially in patients with end-stage disease.40 These homeostatic abnormalities are now thought to be the result of secretion of a parathyroid-related protein as well as secretion of cytokines such as transforming growth factor-beta (TGF-β), interleukin-1 (IL-1), and tumor necrosis factor (TNF).41 Hypercalcemia is commonly treated with IV fluid rehydration and bisphosphonate administration; left untreated, it can result in cardiac or kidney dysfunction, and even death in extreme cases.42

Coagulation abnormalities also occur commonly in this patient population. This can be attributed both to their cancer diagnosis as well as to an association with neurosurgical procedures.43 Coagulopathies can result from metastatic tumor spread to the liver or more commonly from the toxic side effects of chemotherapeutic agents. In addition, frequent blood transfusions that some of these patients receive may result in antiplatelet antibodies, which may be resistant to replacement transfusions. Thrombocytopenia may result from diffuse bone marrow replacement or wide field irradiation, but commonly results from chemotherapy or common medications, such as heparin. A blood panel for heparin-induced thrombocytopenia (HIT) is obtained for patients taking heparin or heparin analogues who are thrombocytopenic, and the medication should be stopped. Treatment for coagulopathies depends primarily on the underlying cause.44

Diminished pulmonary reserve is another abnormality that is encountered quite commonly in patients with metastatic tumors. For example, patients undergoing thoracotomy for the treatment of lung cancer may be left with marginal reserve capacity. This is also seen as a result of multiple lung metastases, interstitial pulmonary fibrosis secondary to chemotherapy, pleural effusion, and the consequences of smoking. At our institution, all patients obtain a chest radiograph, and any patients with prior thoracotomy, any previously mentioned risk factor, or a history of dyspnea have their cases evaluated with preoperative pulmonary function tests.

Cancer patients are also at an increased risk for developing deep venous thrombosis (DVT).45 The etiology is thought to be multifactorial and not simply a result of immobility. Many solid tumors release cytokines and other tissue factors that have procoagulant effects. We have found perioperative prophylaxis with pneumatic compression boots and subcutaneous dalteparin (Fragmin, 5000 units SQ bid) to be helpful in decreasing the rate of postoperative DVT, but not foolproof. Patients immobilized with paresis or pain, routinely undergo Doppler ultrasounds prior to surgery. Any DVT identified preoperatively is managed with inferior vena cava filter placement. Leon et al. showed a benefit to prophylactic filter placement for patients undergoing major spine surgery.46 Risk factors for pulmonary embolism included malignancy, prior history of thromboembolism, bedridden more than 2 weeks prior to surgery, staged or multilevel procedures, and prolonged surgery (>8 hours). Consideration for placement of removable vena cava filters should be given to any tumor patient with a significant paresis or plegia who will need to intermittently discontinue full-dose anticoagulation. Postoperatively, DVTs are treated with either inferior vena cava filters or anticoagulation.

Many patients treated for spinal cord compression are also undergoing active chemotherapeutic treatment for either their primary disease or to control metastatic disease. A major concern is that many of these agents affect blood counts for several days after their administration. This may place patients at risk for neutropenia, anemia, or thrombocytopenia, all of which can have devastating consequences if not considered preoperatively.

Estimating Tumor Burden in Other Regions

The presence of distant metastases to extraspinal sites and active disease at the primary site are not contraindications to spine surgery, but recognizing the extent of disease is important for decision making. In patients with diffusely metastatic or rapidly progressive tumor, options such as irradiation may be more appropriate. However, we often determine the appropriateness of surgical interventions based more on the patient’s overall medical condition than the tumor load. Even in cases with limited life expectancy (3–6 months), decompression and stabilization may help preserve neurologic function, and thus quality of life, as well as palliate pain symptoms with an acceptable level of morbidity.

At MSKCC, tumor staging is usually performed in conjunction with the primary oncologists, who have a better appreciation of the patient’s disease in terms of overall aggressiveness and pace of progression.6 This workup is typically performed with radiographic studies, including CT with and without contrast of the chest, abdomen, and pelvis. PET-CT is more commonly used as a screening method. Serum markers can also be used to screen for the presence or progression of tumors, such as prostate-specific antigen (PSA, prostate carcinoma), CA-125 (breast carcinoma), and carcinoembryonic antigen (CEA, colon carcinoma). These markers are remarkably sensitive and may be an early indicator of tumor recurrence. In hormone-refractory prostate carcinoma with spine involvement, the PSA often serves as a marker for tumor recurrence well in advance of scheduled surveillance MRI.