Refractive lens exchange

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CHAPTER 31 Refractive lens exchange

History

Early in the year 1890, Fukala reported on refractive lens extraction in eyes with high myopia1. This procedure was subsequently abandoned due to the 10-fold increase of post-operative retinal detachment in comparison to unoperated myopic eyes. Since 1890, ophthalmic surgery has undergone steady changes by means of innovations in intraocular lens design, application of ophthalmic viscoelastics substances, and development of phacoemulsification and microincisional surgical techniques. These innovations improved the safety and efficacy of refractive lens exchange (RLE), making it an integral part of refractive surgery today.

Complications in refractive lens exchange

The complication spectrum of RLE is similar to that following cataract surgery with some differences. RLE is implemented in very short or very long eyes and patients’ ages are significantly lower. From this specific situation certain risks emanate: the postoperative retinal pathologies after myopic RLE and typical intraoperative difficulties induced by short anterior segment in hyperopic RLE.

Postoperative complications

Retinal detachment

Incidence of rhegmatogenous retinal detachment (RD) (Fig. 31.2) in the general population is 0.02%6. The risk for development of RD increases with myopia due to higher degree of retinal and vitreous degenerations, posterior vitreous detachment, and retinal hole formation7. Phacoemulsification also increases the risk of RD and, as shown in Table 31.2, the combination of both myopia and phacoemulsification markedly enhances this risk. Intraoperative complications such as rupture of the capsular bag or vitreous loss elevate the risk up to 8.0%, even in the general population. Published data on the incidence of RD after phacoemulsification in myopes vary greatly depending on the particular study; from 0 to 8.1% in one single study as shown in Table 31.3, which includes a meta-analysis of publications from 1994 to 2008 dealing with this issue8. The majority of these publications are studies with a retrospective design. Considering the given incidences in Table 31.3, one must note the wide variation concerning the different particular operative techniques (e.g. ICCE, ECCE), the degree of myopia, and the length of follow-up between the studies. In addition, microincisional surgery and IOL with sharp optic edge design were not available until recently. The incidence of PCO was consequently higher in the young patient collectives and Nd:YAG-capsulotomy had to be performed more often. There is an overall tendency that all studies with a RD rate of 0 % embrace a follow-up of less than 4 years and studies with a longer follow-up indicate higher rates of RD. In order to estimate the real cumulative incidence of RD after RLE, an adequate long-term follow-up is mandatory as it has been shown that the cumulative risk of RD after lens surgery increases in a linear fashion over time9. Therefore, one should consider the cumulative risk of RD for young myopes that undergo RLE to be somewhat higher with respect to their significantly longer life expectancy.

Table 31.2 Incidences of rhegmatogenous retinal detachment

General population 0.02%
Myope >10 D 0.7%
General population after phacoemulsification 1.2% (10 years)
Myope after phacoemulsification 0–8.1%
Young myope (<50 years) after phacoemulsification 5.2%
General population after complicated phacoemulsification 8.0%
Myope after complicated phacoemulsification >8.0%

Deductively, identifiable risk factors for RD after RLE are high axial length, age >50 years, male gender, Caucasian race, existence of peripheral retinal degenerations, intraoperative complications such as rupture of the capsule with vitreous loss, and postoperative application of laser capsulotomy for treatment of PCO.

There is a completely different risk profile for RD after hyperopic RLE. Hyperopic eyes exhibit a short axial length and do not display any intrinsic retinal pathology. Thus, published data of several retrospective studies have not shown a single case of RD after hyperopic RLE during a follow-up of up to 6 years.

PCO after RLE

Independent of the type of implanted IOL, RLE causes an increased rate of posterior capsule opacification (PCO) (Fig. 31.3) due to the younger age of the patients. Thus, only IOL with sharp edge design should be used in RLE. IOL should be centered in the capsular bag and anterior capsulorrhexis should overlap the IOL (Fig. 31.4). Avoiding PCO is important in order to reduce complications associated with Nd:YAG capsulotomy such as elevation of IOP, iritis, vitreous prolapse, posterior vitreous detachment, cystoid macular edema, or RD. Published data concerning the incidence of RD after lens surgery and subsequent laser capsulotomy vary between 0 and 4%10,13. It is noteworthy that some authors postulate the incidence of RD after laser capsulotomy is not due to the application of the energy of the laser, but rather to the opening of the posterior capsule itself11. A direct correlation of mode, configuration, point of time after lens surgery, or level of applied energy of laser capsulotomy has not yet been substantiated in any study. However, the risk of RD after laser capsulotomy increases significantly with the degree in high myopia. Therefore after RLE, one should carefully weigh the risks of laser capsulotomy in eyes with beginning PCO and an axial length of more than 24 mm against the benefit of some gain in visual acuity12. In some cases it may be advisable to perform surgical polishing of the posterior capsule instead of using the laser in order to avoid opening of the posterior capsule.

References

1 Fukala V. Behandlung der höchstgradigen Myopie durch Aphakie. Graefes Arch Ophthalmol. 1890;36:230-244.

2 Terzi E, Wang L, Kohnen T. Accuracy of modern intraocular lens power calculation formulas in refractive lens exchange for high myopia and high hyperopia. J Cataract Refract Surg. 2009;35(7):1181-1189.

3 Speaker MG, Guerriero PN, Met JA, et al. A case-control study of risk factors for intraoperative suprachoroidal expulsive hemorrhage. Ophthalmology. 1991;98(2):202-209. discussion 10

4 Kim HK, Shin JP. Capsular block syndrome after cataract surgery: clinical analysis and classification. J Cataract Refract Surg. 2008;34(3):357-363.

5 O’Grady RB. Nanophthalmos. Am J Ophthalmol. 1971;71(6):1251-1253.

6 Polkinghorne PJ, Craig JP. Northern New Zealand Rhegmatogenous Retinal Detachment Study: epidemiology and risk factors. Clin Exp Ophthalmol. 2004;32(2):159-163.

7 Perkins ES. Morbidity from myopia. Sight Sav Rev. 1979;49(1):11-19.

8 Colin J, Robinet A, Cochener B. Retinal detachment after clear lens extraction for high myopia: seven-year follow-up. Ophthalmology. 1999;106(12):2281-2284. discussion 5

9 Javitt JC. Clear-lens extraction for high myopia. Is this an idea whose time has come? Arch Ophthalmol. 1994;112(3):321-323.

10 Dardenne MU, Gerten GJ, Kokkas K, et al. Retrospective study of retinal detachment following neodymium:YAG laser posterior capsulotomy. J Cataract Refract Surg. 1989;15(6):676-680.

11 Winslow RL, Taylor BC. Retinal complications following YAG laser capsulotomy. Ophthalmology. 1985;92(6):785-789.

12 Koch DD, Liu JF, Gill EP, et al. Axial myopia increases the risk of retinal complications after neodymium-YAG laser posterior capsulotomy. Arch Ophthalmol. 1989;107(7):986-990.

13 Kohnen T, Fabian E, Gerl R, et al. Optic edge design as long-term factor for posterior capsular opacification rates. Ophthalmology. 2008;115:1308-1314.