Chapter 7 Global Developmental Delay and Regression
Developmental delay occurs in approximately 1% to 3% of children. Since developmental delay is common, monitoring a child’s development is an essential component of well-child care. Ongoing assessment of the child’s development at each well-child visit creates a pattern of development that is more useful than measuring the discrete milestone achievements at a single visit; therefore, developmental screening should be completed at each well-child visit (Council on Children with Disabilities, 2006). Identification of a child with developmental delays should be accomplished as early as possible, because the earlier a child is identified, the sooner the child can receive a thorough evaluation and begin therapeutic interventions that can improve the child’s outcome. Developmental delay is common and one of the most frequent presenting complaints to a pediatric neurology clinic; neurologists should have a systematic approach to the child with developmental delay.
Typical and Atypical Development
Child Development Concepts
On average, most children achieve each developmental milestone within a defined and narrow age range (Table 7.1). Usually physicians learn the average age for acquiring specific skills. However, since each developmental skill can be acquired within an age range, it is much more useful clinically to know when a child’s development falls outside this range. These so-called red flags are important because they can be used to identify when a child has developmental delay for specific skills. For example, although the average age of walking is approximately 13 months, a child may walk as late as 17 months and still be within the typical developmental range. In this example, the red flag for independent walking is 18 months, and a child who is not walking by 18 months of age is delayed.
Global Developmental Delay
Neurological and Other Medical History
For children with global developmental delay, the clinician should obtain a thorough medical history, including a detailed neurological history. Pertinent aspects of the history include the presence of any other neurological condition such as epilepsy, vision or hearing impairments, ataxia or a movement disorder, sleep impairment, and behavioral problems. The clinician should also inquire about prenatal, perinatal, and postnatal factors that can impact a child’s development (Tables 7.2 and 7.3). The social history should probe for environmental factors that can affect development, including physical or other forms of abuse, neglect, psychosocial deprivation, family illness, impaired personalities in family members, sociocultural stressors, and the economic status of the family.
Prenatal/Perinatal | Examples |
---|---|
Congenital malformations of the CNS | Lissencephaly, holoprosencephaly |
Chromosomal abnormalities | Down syndrome, Turner syndrome |
Endogenous toxins | Maternal hepatic or renal failure |
Exogenous toxins from maternal use | Anticonvulsants, anticoagulants, alcohol, drugs of abuse |
Fetal infection | Congenital infections |
Prematurity and/or fetal malnutrition | Periventricular leukomalacia |
Perinatal trauma | Intracranial hemorrhage, spinal cord injury |
Perinatal asphyxia | Hypoxic-ischemic encephalopathy |
Postnatal | Examples |
Inborn errors of metabolism | Aminoacidopathies, mitochondrial diseases |
Abnormal storage of metabolites | Lysosomal storage diseases, glycogen storage diseases |
Abnormal postnatal nutrition | Vitamin or calorie deficiency |
Endogenous toxins | Hepatic failure, kernicterus |
Exogenous toxins | Prescription drugs, illicit substances, heavy metals |
Endocrine organ failure | Hypothyroidism, Addison disease |
CNS infection | Meningitis, encephalitis |
CNS trauma | Diffuse axonal injury, intracranial hemorrhage |
Neoplasia | Tumor infiltration, radiation necrosis |
Neurocutaneous syndromes | Neurofibromatosis, tuberous sclerosis complex |
Neuromuscular disorders | Muscular dystrophy, myotonic dystrophy |
Vascular conditions | Vasculitis, ischemic stroke, sinovenous thrombosis |
Other | Epilepsy, mood disorders, schizophrenia |
CNS, Central nervous system.
From Sherr, E.H., Shevell, M.I., 2006. Mental retardation and global developmental delay, in: Swaiman, K.F., Ashwal, S., Ferriero, D.I. (Eds.), Pediatric Neurology, Principles and Practice, fifth ed. Mosby, Philadelphia.
Maternal/Prenatal | Natal | Postnatal |
---|---|---|
Age <16 years or >40 years | Intrauterine hypoxia: prolapsed umbilical cord, abruptio placenta, circumvallate placenta | Abnormal feeding: poor sucking, weight gain, malnutrition, vomiting |
Cervical or pelvic abnormalities | Midforceps delivery or breech presentation | Abnormal crying |
Maternal illnesses: infection, shock, diabetes, nephritis, phlebitis, proteinuria, renal hypertension, thyroid disease, drug addiction, malnutrition | Poor Apgar scores: cyanosis, poor respiratory effort, bradycardia, poor reflexes, hypotonia | Abnormal exam: asymmetrical face, asymmetrical extremities, dysmorphic features, hypotonia, birth injuries, seizures |
Maternal features: unmarried, uneducated, nonwhite, low-income, thin, short | Need for resuscitation: respiratory distress, bradycardia, hypotension | Abnormal findings: hyperbilirubinemia, fever, hypothermia, hypoxia |
Consanguinity | Gestational age <30 weeks | |
Prior abnormal pregnancy, miscarriages, stillbirths, abortions, neonatal deaths, infants less than 1500 g, abnormal placenta | Vaginal bleeding in the second or third trimester | |
Hypoxic-ischemic encephalopathy | ||
Polyhydramnios or oligohydramnios |
From Sherr, E.H., Shevell, M.I., 2006. Mental retardation and global developmental delay, in: Swaiman, K.F., Ashwal, S., Ferriero, D.I. (Eds.), Pediatric Neurology, Principles and Practice, fifth ed. Mosby, Philadelphia.