Fungal Diseases

Published on 05/03/2015 by admin

Filed under Dermatology

Last modified 05/03/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 2.5 (2 votes)

This article have been viewed 9820 times

64

Fungal Diseases

Superficial Fungal Infections

Tinea (Pityriasis) Versicolor

Secondary to transformation of Malassezia spp., especially M. furfur, from the yeast form to the hyphal form (see Fig. 2.1A).

Malassezia spp. are part of the normal flora.

Multiple, brown (hyperpigmented), tan (hypopigmented), or pink, oval to round macules, patches, or thin plaques; there is often coalescence of lesions centrally with scattered lesions at the periphery.

Associated scale may be subtle but becomes more obvious with gentle scratching or stretching of the skin.

Most commonly develops on the upper trunk and shoulders, but can also involve flexural sites such as the antecubital fossae, submammary folds, and groin (Fig. 64.1); in children more frequently than adults, there can also be facial involvement.

Often first noticed in the summer, and a suntan accentuates the hypopigmented variant.

DDx: postinflammatory hypopigmentation and idiopathic macular hypomelanosis (if hypopigmented); confluent and reticulated papillomatosis of Gougerot and Carteaud (if hyperpigmented; see Chapter 89).

Rx: outlined in Table 64.1.

Following appropriate Rx, the associated hypopigmentation may persist for months until there is repigmentation or fading of the suntan.

Tinea Nigra, Black Piedra, and White Piedra

Typically seen in tropical areas.

Tinea nigra.

Most commonly due to infection with Hortaea werneckii, a pigmented fungus found in soil.

Brown, sharply marginated macule or patch; most commonly on the palms (Fig. 64.2).

Rx: keratolytic agents (e.g. salicylic acid 6% cream) and topical antifungals (e.g. terbinafine 1% cream).

Black piedra and white piedra are characterized by the formation of nodules on hair shafts (Table 64.2; Fig. 64.3).

Dermatophytoses (Tinea Infections)

The names of dermatophyte infections consist of the word ‘tinea’ followed by the Latin name for the involved body site; examples are tinea pedis (foot) and tinea cruris (groin) (Fig. 64.4).

Due to fungi of three genera – Trichophyton, Microsporum, and Epidermophyton – that invade only keratinized tissue (stratum corneum, hair, and nails).

With the exception of tinea capitis, Trichophyton rubrum and T. mentagrophytes are the most common pathogens.

Trichophyton mentagrophytes has two major variants that infect the skin, which can lead to confusion; T. mentagrophytes var. interdigitale is spread human-to-human, whereas T. mentagrophytes var. mentagrophytes is acquired from animals; these variants are also known as T. interdigitale [anthropophilic] and [zoophilic], respectively.

Transmission occurs via close contact with infected humans or domestic animals, occupational or recreational exposure (e.g. locker rooms), and contact with contaminated clothing, furniture, or brushes; the latter inanimate objects serve as fomites.

More commonly seen in adults, with the exception of tinea capitis, which occurs more often in children.

The classic presentation is an erythematous, annular lesion with an active, scaly border; superficial pustules may also be present (Fig. 64.5).

Occasionally, vesicles may develop, especially in tinea pedis or manuum due to T. mentagrophytes.

Dx: KOH ± fungal culture of skin scrapings (see Fig. 2.1) as well as hairs and nails, in the case of tinea capitis and tinea unguium, respectively.

Important variants:

Tinea incognito refers to atypical clinical presentations, often due to inappropriate treatment with potent topical CS or combination topical therapies that contain CS; lesions may lack scale or be minimally inflamed (Fig. 64.6; see Fig. 64.5E).

Majocchi’s granuloma is characterized by erythematous papules or pustules within an area of tinea corporis; the papules represent sites of hair shaft invasion, usually due to T. rubrum; often seen in women with tinea pedis who shave their legs or in immunosuppressed patients (see Fig. 31.4A; Fig. 64.7).

Examples of Specific Types of Dermatophytoses

Tinea pedis (Fig. 64.8).

Most commonly due to T. rubrum or T. mentagrophytes var. interdigitale > Epidermophyton floccosum.

Three major types: (1) interdigital – erythema, scaling, and maceration in the web spaces, especially the two lateral web spaces, which have the most occlusion; can be accompanied by fissures as well as superimposed bacterial infection; (2) moccasin – diffuse scaling and erythema that extends onto the lateral aspect of the feet; and (3) inflammatory (vesicular) – vesicles and bullae, especially on the medial aspect of the plantar surface.

Occasionally, especially in immunocompromised and diabetic patients, a more severe ulcerative toe-web infection can occur where there is both a dermatophyte and a bacterial (e.g. pseudomonal) infection; see discussion of gram-negative toe-web infection in Chapter 61.

Consider use of oral antifungal medications if the tinea pedis fails to respond to topical agents or is severe (Table 64.3).