Figurate Erythemas

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15

Figurate Erythemas

A number of cutaneous diseases can have an annular, arciform, or polycyclic configuration, from urticaria to granuloma annulare and tinea corporis (Table 15.1). Sites of involvement, rate of expansion, and characteristics of the border assist in narrowing the differential diagnosis, along with histologic examination of the active edge. This chapter discusses in more detail the classic figurate erythemas.

Erythema Annulare Centrifugum (EAC)

Annular, arciform, and polycyclic plaques due to infiltrates of lymphocytes within the dermis; lesions usually last for a few weeks to months and as they migrate centrifugally, there is central clearing; recurrences are common.

This gyrate erythema is sometimes divided into superficial and deep forms, based on clinicopathologic findings, with the superficial form being minimally elevated with “trailing” white scale (Fig. 15.1A) and the deep form having a more infiltrated border (Fig. 15.1B); some authors reserve the designation EAC for the superficial form.

Color varies from pink to darker red-violet, with the superficial form favoring the thighs and deeper the trunk; peak incidence is during the fifth decade.

Often idiopathic, but some cases appear to be a reactive process triggered by fungal infections, in particular tinea pedis, or less often, viral infections or medications.

DDx: Tinea corporis (especially if scale is present); if no surface changes, annular urticaria (Fig. 15.2), benign lymphocytic infiltrate (of Jessner), cutaneous lymphoid hyperplasia, cutaneous lupus erythematosus (tumidus), and lymphoma cutis as well as the other entities covered in this chapter and Table 15.1; in some patients, the diagnosis of EAC is rendered after exclusion of other disorders.

Rx: if trigger identified, it should be treated; if no trigger is identified, topical CS may be of some benefit.

Erythema Migrans (EM; Erythema Chronicum Migrans [ECM])

Cutaneous manifestation of the earlier stages of infection with Borrelia burgdorferi spirochetes; seen in 60–90% of patients diagnosed with Lyme borreliosis.

Occurs most commonly in the United States (northeast, upper Midwest, west coast), Scandinavia, and central Europe; natural hosts are white-footed mice and white-tailed deer.

Can be localized to the site of the bite of an infected Ixodes tick (Fig. 15.5) or as the disease progresses, become disseminated with multiple secondary lesions (Fig. 15.6); several species of Ixodes can transmit disease, including I. scapularis, I. pacificus, I. ricinus.

At the site of the tick bite, usually after a period of 1 or 2 weeks (range 2–28 days), an erythematous patch or plaque appears that expands over days to weeks to reach a diameter of at least 5 cm; central clearing can result in an annular lesion and sometimes the lesion has a bull’s-eye appearance; occasionally, vesicles are seen.

Primary lesions often favor body folds, are frequently asymptomatic and spontaneously resolve (without treatment) within 6 weeks; primary, and especially disseminated, lesions can be accompanied by flu-like symptoms – headache, malaise, arthralgia, myalgia, and fever.

Transmission usually requires attachment of the infected Ixodes tick for over 24 hours; if untreated, sequelae include arthritis, Bell’s palsy, and atrioventricular heart block (Table 15.2); Ixodes ticks may also transmit babesiosis and human anaplasmosis.

Development of additional cutaneous findings (e.g. pseudolymphoma, acrodermatitis chronica atrophicans; Fig. 15.7) is seen in individuals infected outside the United States and reflects the geographic distribution of different genospecies of Borrelia, e.g. B. afzelii is found in Europe but not the United States.

DDx: exaggerated local reaction to an arthropod bite, cellulitis, allergic contact dermatitis, southern tick-associated rash illness (STARI), nonpigmented fixed drug eruption, and other causes of pseudocellulitis (see Table 61.2); of note, peak specific IgM antibodies usually appear at 3–6 weeks into infection so they may not be detected in patients with early EM (false-negative rate as high as 60%).

Rx is outlined in Table 15.3; for patients who (1) live in an endemic area, (2) had a tick attached for >36 hours, (3) removed the tick within the past 72 hours, and (4) had the tick identified as I. scapularis, a single dose of oral doxycycline (200 mg) may reduce the risk of developing Lyme borreliosis from 3.2% to 0.4%.

For further information see Ch. 19. From Dermatology, Third Edition.