Erythema dyschromicum perstans

Published on 19/03/2015 by admin

Filed under Dermatology

Last modified 22/04/2025

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Erythema dyschromicum perstans

Christine Soon and John Berth-Jones

Evidence Levels:  A Double-blind study  B Clinical trial ≥ 20 subjects  C Clinical trial < 20 subjects  D Series ≥ 5 subjects  E Anecdotal case reports

image

Erythema dyschromicum perstans (EDP) is an acquired, generalized dermal hypermelanosis of unknown etiology. Clinically it presents as asymptomatic, ashen-gray-blue macules of varying sizes, most commonly on the trunk and proximal extremities. Variable components include erythema and papulation. It has been reported most frequently in dark-skinned Latin-American people, although all racial groups can be affected. EDP has similarities to lichen planus pigmentosus and the ‘ashy dermatosis’ of Ramirez, although the precise relationship of these conditions has yet to be established.

Therapy

image No therapy D
image Vitamin A D
image Dapsone 100 mg/day for 3 months D
image Oral corticosteroid therapy E
image Clofazimine 100 mg/day for 3 months D

[/level-membership-for-dermatology-category][not-level-membership-for-dermatology-category]70

Erythema dyschromicum perstans

Christine Soon and John Berth-Jones

Evidence Levels:  A Double-blind study  B Clinical trial ≥ 20 subjects  C Clinical trial < 20 subjects  D Series ≥ 5 subjects  E Anecdotal case reports

image

Erythema dyschromicum perstans (EDP) is an acquired, generalized dermal hypermelanosis of unknown etiology. Clinically it presents as asymptomatic, ashen-gray-blue macules of varying sizes, most commonly on the trunk and proximal extremities. Variable components include erythema and papulation. It has been reported most frequently in dark-skinned Latin-American people, although all racial groups can be affected. EDP has similarities to lichen planus pigmentosus and the ‘ashy dermatosis’ of Ramirez, although the precise relationship of these conditions has yet to be established.

Specific investigations

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