Published on 19/03/2015 by admin
Filed under Dermatology
Last modified 19/03/2015
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Christine Soon and John Berth-Jones
Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports
Erythema dyschromicum perstans (EDP) is an acquired, generalized dermal hypermelanosis of unknown etiology. Clinically it presents as asymptomatic, ashen-gray-blue macules of varying sizes, most commonly on the trunk and proximal extremities. Variable components include erythema and papulation. It has been reported most frequently in dark-skinned Latin-American people, although all racial groups can be affected. EDP has similarities to lichen planus pigmentosus and the ‘ashy dermatosis’ of Ramirez, although the precise relationship of these conditions has yet to be established.
No controlled trials have been reported. Although EDP may persist for many years, there have been reports of spontaneous resolution. Camouflage creams can be prescribed for cosmetic purposes. The treatments discussed below have also been tried, with varying success. Treatments that are reportedly ineffective include sun protection, peeling lotions, antibiotics, topical hydroquinone, topical corticosteroid therapy, antimalarials, and griseofulvin.
Biopsy
Treatment of Skin Disease Comprehensive Therapeutic Strategies 4e
