Coronary artery stents

Published on 07/02/2015 by admin

Filed under Anesthesiology

Last modified 07/02/2015

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Coronary artery stents

Amy G. Voet, DO, MS and James A. Giacalone, BS, MEd

Coronary artery stents were first developed in the 1980s and are now placed in most percutaneous coronary interventions (PCIs). Interventional cardiologists have a wide choice of stents for implantation. The choices range from bare-metal stents (BMSs) and drug-eluting stents (DESs) (Table 144-1) that are widely used in contemporary practice to new stents, such as DESs with novel coatings, biodegradable stents, DESs with biodegradable polymers, DESs that are polymer free, dedicated bifurcation stents, and self-expanding stents. A number of DESs are currently undergoing study or are available outside the United States (Table 144-2).

Table 144-1

U.S. Food and Drug Administration–Approved Drug-Eluting Stents

Stent Manufacturer Drug Eluted
Cypher J&J Cordis Sirolimus
TAXUS Express and Liberté Boston Scientific Paclitaxel
Endeavor Medtronic Zotarolimus
Xience V Guidant, Abbott Everolimus

Table 144-2

Metallic Stents Available Outside the United States or Undergoing Clinical Evaluation

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Stent Drug(s) Eluted Approved Outside U.S. Ongoing Trials
Endeavor RESOLUTE Zotarolimus X  
Elixir DESyne Novolimus   X
TAXUS Element Paclitaxel X  
PROMUS Element Everolimus X  
Supramilus Sirolimus   X
Excel Stent Sirolimus   X
NEVO Sirolimus   X
BioMatrix Biolimus A9 X  
NOBORI Biolimus A9 X  
Axxess Biolimus A9 X  
XTENT Biolimus A9 X  
SYNERGY Everolimus   X
Combo EPC + sirolimus   X
Elixir Myolimus Myolimus   X
Infinnium Paclitaxel   X
JACTAX LibertĂ© Paclitaxel   X
AmazoniaPax Paclitaxel X  
BioFREEDOM Biolimus A9   X