Clinical Vignette

A 45-year-old man with a history of bipolar disorder and binges of alcohol abuse gradually developed global headaches that suddenly worsened over a 6-day period. He presented to the emergency room reporting excruciating headaches, especially while lying flat or after coughing. He described visual blurring and transient visual dimming while straining or getting up abruptly. He was slightly inattentive but had no focal weakness or numbness on examination. Ophthalmoscopy showed bilateral severe papilledema with peripapillary flame-shaped hemorrhages but no visual field loss. Computed tomographic (CT) scan of the brain showed hyperdensity in the sagittal sinus and the left transverse sinus. Cerebrospinal fluid (CSF) fluid analysis was normal but the opening pressure was elevated. Magnetic resonance imaging (MRI) of the brain showed no acute stroke or hemorrhage, but magnetic resonance venography (MRV) showed partial occlusion of the sagittal sinus, left transverse sinus, and the left jugular vein. He later admitted to drinking heavily and smoking just before his headaches worsened. There was no evidence of malignancy, and initial coagulation studies were normal. He was treated with warfarin and acetazolamide with no evidence of progressive visual loss and ultimately resolution of the headaches. Serial MRVs showed partial recanalization of the occluded cerebral sinuses and he was eventually taken off warfarin. He was admitted about 6 months later with recurrent episodes of shortness of breath and palpitations and was found to have multiple small pulmonary emboli and deep vein thrombosis. A repeat hypercoagulability screen revealed a lupus anticoagulant, and a newly available test showed the presence of a prothrombin gene mutation. He was advised to stay on warfarin life-long.

Clinical Vignette

A 34-year-old man presented to the hospital after 1 week of increasing occipital headache, stiff neck, and chills. Brain CT and CSF analysis were normal; however, the patient was admitted to the hospital for worsening confusion and behavioral changes. Soon after admission, he had a generalized tonic-clonic seizure and underwent intubation.

A brain MRI demonstrated bilateral frontal hemorrhagic infarctions with edema and a sagittal sinus thrombosis. Because of obtundation and signs of increased intracranial pressure (ICP), mannitol and an IV heparin infusion were started. A continuous intrasinus infusion of urokinase was given over 2 days. The thrombosis resolved, and he recovered consciousness.

Eventually, the patient was discharged from the hospital on warfarin and anticonvulsants, with only minor left-sided sensory changes and mild left leg weakness. Unfortunately, he did not continue the prescribed anticoagulants and was readmitted 20 days later with pleuritic chest pain and shortness of breath. Bilateral deep vein thrombosis and a pulmonary embolism were diagnosed. An infrarenal inferior vena cava filter was inserted, and anticoagulation was resumed. The patient had a positive test result for anticardiolipin antibodies. This led to the diagnosis of an anticardiolipin antibody syndrome, confirming the need for long-term systemic anticoagulation.

Anatomy

Although complex, cerebral venous system anatomy is best considered in three levels: the dural-based posterosuperior group, the dural anteroinferior or basal group, and the deep veins of the brain.

The dura is formed of two layers, one abutting the inner calvarium and the other forming the outer meningeal covering. These layers separate in the midsagittal and transverse planes, forming dural venous sinuses ultimately draining into the jugular veins. A single superior sagittal sinus joins the often asymmetric but paired transverse sinus at the confluence of sinuses or torcular herophili (Fig. 56-1). The transverse sinuses run laterally from the occipital bone to the middle cerebral fossa along the tentorium cerebelli. The right is often larger and is continuous with the superior sagittal sinus whereas the left curves out laterally as an extension of the single midline straight sinus. The straight sinus runs downward from near the splenium of the corpus callosum to the occipital protuberance. The sigmoid sinus curves down toward the skull base from the transverse sinus and joins the inferior petrosal sinus at the jugular foramen to form the jugular vein.

Figure 56-1 Dura Mater Venous Sinuses.

The straight sinus (Figs. 56-1 through 56-4) is formed by the splayed falx layered over the cerebellar tentorium. The inferior sagittal sinus runs in the fold of the lower arch of the falx cerebri and joins the cerebral vein of Galen in the proximity of the posterior horns of the lateral ventricles to form the straight sinus. The superior and inferior sagittal sinuses provide drainage for the cerebral hemispheres.

Figure 56-2 Deep and Subependymal Veins of Brain.

Figure 56-3 Subependymal Veins.

Figure 56-4 Veins of Posterior Cranial Fossa.