Breathing systems and their components

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Chapter 5 Breathing systems and their components

Definitions

• Breathing systems. In this chapter the term breathing system may be used to describe both the apparatus and the mode of operation by which medical gasses and inhalational agents are delivered to the patient, i.e. a ‘Mapleson D type breathing system’ (mode of operation) would describe the mode of operation of a ‘Bain breathing system’ (apparatus). The term breathing circuit seems to have reappeared also in this context in current anaesthetic literature. However, strictly speaking, a circuit refers to apparatus that allows recirculation of medical gasses and vapours and does not accurately describe other pieces of apparatus used for medical gas delivery

• Rebreathing. Rebreathing in anaesthetic systems now conventionally refers to the rebreathing of some or all of the previously exhaled gasses, including carbon dioxide and water vapour. (Rebreathing apparatus in other spheres, e.g. fire fighting and underwater diving, has always referred to the recirculation of expired gas suitably purified and with the oxygen content restored or increased.)

• Apparatus dead space. This refers to that volume within the apparatus that may contain exhaled patient gas and which will be rebreathed at the beginning of a subsequent inspiratory breath (Fig. 5.1).

• Functional dead space. Some systems may well have a smaller ‘functional’ dead space owing to the flushing effect of a continuous fresh gas stream at the end of expiration replacing exhaled gas in the apparatus dead space (Fig. 5.2).

Classification of breathing systems

These may be classified according to function:

Non-rebreathing systems

The simplest way to deliver a consistent fresh gas supply to a patient is with a system that utilizes a non-rebreathing valve (or valves).

Fresh gas enters the system via an inspiratory limb (Fig 5.3A). This is a length of hosing that has a sufficiently wide bore to minimize any resistance to airflow. It is reinforced so as to prevent collapse from sub-atmospheric pressure either by manufacturing it with corrugations or by bonding a reinforcing spiral onto the outside of the hose. Both of these methods also allow the tube to bend without kinking. The fresh gas entering is either sucked in by the patient’s inspiratory effort or blown in during controlled ventilation and enters the non-rebreathing valve. This valve is so constructed that when it opens to admit inspiratory gas, it occludes the expiratory limb of the system (see Fig. 5.3A). When the patient exhales, the reverse occurs, i.e. the valve mechanism moves to occlude the inspiratory limb and opens the expiratory limb to allow expired gasses to escape (Fig. 5.3B).

The inspiratory limb usually includes a bag (1.5–2 litres capacity) that acts as a reservoir for fresh gas. This reservoir contains enough gas to cope with the intermittent high demand that occurs at inspiration. For example, a patient breathing normally (with a minute volume of 7 litres) may well have a tidal volume of 500 ml inhaled over approximately 1 s. This produces an average inspiratory flow rate (not peak flow rate) of 30 l min−1. Without this reservoir in the system, the fresh gas flow rate would have to at least match this figure (probably more, to match the patient’s peak inspiratory flow rate) in order to avoid respiratory embarrassment.

The reservoir bag is refilled with fresh gas during the expiratory phase. It can also be compressed manually to provide assisted or controlled respiration since the non-rebreathing valve works equally effectively in this mode as it does for spontaneous respiration.

In the non-rebreathing system described, the fresh gas flow rate must not be less than the minute volume required by the patient.

Systems where rebreathing is possible

A miscellany of breathing systems was developed by early pioneers (largely intuitively) that allowed the to-and-fro movement of inspiratory and expiratory gasses within the breathing system. Carbon dioxide elimination was achieved by the flushing action of fresh gas introduced into this breathing system, rather than by separation of the inspiratory and expiratory gas mixtures by a non-rebreathing valve as described above. As it is mainly the flushing effect of fresh gas that eliminates carbon dioxide, these systems retain the potential for rebreathing of carbon dioxide when fresh gas flow rates are reduced.

Mapleson (1954) classified these systems (A to E) according to their efficiency in eliminating carbon dioxide during spontaneous respiration. An F system, the Jackson Rees modification of system E (Ayre’s T-piece), was later added to the classification by Willis (1975), (see below).

Mapleson’s classification of breathing systems

Fig. 5.4 illustrates a modified Mapleson classification of breathing systems. These all contain similar components but are assembled in different sequences in order to be used more conveniently in specific circumstances. However, as a result, the efficiency of each system is different. They are catalogued in order (A, B, C, D, E, F) of increased requirement of fresh gas flow to prevent rebreathing during spontaneous respiration. System A requires. 0.8–1 times the patient’s minute ventilation, B and C require 1.5–2 times the patient’s minute ventilation and systems D, E and F (all functionally similar) require 2–3 times the patient’s minute ventilation to prevent rebreathing during spontaneous respiration.

Working principles of breathing systems

Mapleson A breathing system

The Mapleson A system illustrated in figure 5.5 is the ‘Magill attachment’ as popularized by Sir Ivan Magill in the 1920s. It consists of the following:

This system makes efficient use of fresh gas during spontaneous breathing that can be explained by examining its function during a respiratory cycle consisting of three phases: inspiration, expiration, and an end-expiratory pause.

• The first inspiration. In Fig. 5.5A the reservoir bag and breathing hose have been filled by an ideal fresh gas flow and attached (with a gas-tight fit) to the patient, who is about to take a breath. The whole system is therefore full of fresh gas. As the patient inspires, the gasses are drawn into the lungs at a rate greater than the fresh gas flow and so the reservoir bag partially empties as shown in Fig. 5.5B.

• Expiration. In Fig. 5.5C the patient has begun to exhale, and because the reservoir bag is not full, the exhaled gasses are breathed back along the corrugated hose, pushing the fresh gasses in the hose back towards the reservoir bag. However, before the exhaled gasses can pass as far as the reservoir bag (hence the importance of the length of the inspiratory hose), the latter has been refilled by the fresh gasses from the corrugated hose plus the continuing fresh gas flow from the anaesthetic machine.

A point is reached when the reservoir bag is again full and, as the patient is still exhaling, the remaining exhaled gasses have to pass out through the APL (expiratory) valve, which now opens.

The first portion of exhaled gasses to pass along the corrugated hose from the patient was that occupying the patient’s anatomical dead space and, therefore, apart from being warmed and slightly humidified (a satisfactory state of affairs), is unaltered, not having taken part in respiratory exchange. This is followed by alveolar gas (with a reduced oxygen content and containing carbon dioxide), the first part of which may enter the corrugated hose, and the rest which is expelled through the APL valve when the reservoir bag is full.

During the end-expiratory pause, all the alveolar gasses and some of the dead-space gasses are expelled from the corrugated hose through the APL valve by the continuing fresh gas flow. Thus, during the next inspiratory phase, the gas inspired may well initially contain some of the remaining dead-space gasses from the previous breath, along with fresh gas. As explained above, these dead-space gasses may be re-inspired without detriment to the patient. The fresh gas flow rate may, therefore, be rather less than the patient’s minute volume and rebreathing of alveolar gas is, therefore, prevented.

In theory, provided there is no mixing of fresh gas, dead-space gas and alveolar gas and a sufficient end-expiratory pause, the fresh gas flow rate need only match alveolar ventilation (approximately 66% of the minute volume), as in this situation alveolar gas only will be vented through the APL valve.

In practice, however, a number of factors dictate a higher fresh gas flow rate (70–90%), for instance:

Mapleson A system and controlled ventilation

The mechanical aspects of the Mapleson A (Fig. 5.6) system (Magill attachment) as described above relate to its use in spontaneous respiration. However, if controlled or assisted ventilation is used, with the patient’s lungs inflated by means of squeezing the reservoir bag, a different state of affairs occurs. With the same fresh gas flows as before, we would see the following:

When the anaesthetist squeezes the bag again, the first gasses to enter the patient’s lungs will be the previously exhaled alveolar gasses. The volume of gasses escaping via the APL valve during this second inspiratory phase is initially small (the valve being almost closed), but gradually increases as the pressure in the system rises towards the maximum inspiration. Therefore, the greatest amount of gas will he dumped late in the cycle and will consist mainly of fresh gas. Under these circumstances there is considerable rebreathing (Fig. 5.6 see shading). Furthermore, as alveolar gas will have entered the reservoir bag, there will always be carbon dioxide contamination in any subsequent inspirate. In order to prevent this and thereby minimize the potential for rebreathing alveolar gas, a high fresh gas flow rate is required.

This is usually of the order of 2 times the patient’s minute ventilation. This situation is highly wasteful with regard to fresh gas and also increases the potential for pollution.

Other Mapleson A breathing systems

The Lack co-axial breathing system (Fig. 5.7A)

The traditional layout of a Magill system sites the APL valve as close to the patient as possible. However, this:

The Lack system overcomes these two problems. The original version was constructed with a co-axial arrangement of breathing hoses. Exhaled gasses are passed into the orifice of the inner hose sited at the patient end of the system and then back towards the APL valve, which is now sited on the reservoir bag mount. The valve is thus conveniently sited for adjustment by the anaesthetist and its weight, and that of any additional scavenging attachment, is now supported by the anaesthetic machine (see Fig. 5.7). The system still functions as a Mapleson A system. The co-axial hosing on early models was criticised as being too narrow and having too high a flow resistance. In later models, the inner and outer breathing hose diameters were subsequently both increased, to 15 and 30 mm respectively, to overcome this problem. Another problem was that the tubing was heavy and stiff, putting a stress on the connection to the facepiece or endotracheal connection.

Mapleson D system

The Mapleson D system with spontaneous respiration

The system is best explained hypothetically, if again the three phases of the respiratory cycle are considered in sequence: inspiration, expiration and end-expiratory pause.

• The first inspiration. An appropriate fresh gas flow (see later) enters as close as possible to the patient end of the breathing system (so as to reduce any apparatus dead space) and the system including the reservoir bag is filled so that during the first inspiration the patient breathes only fresh gas. As the inspiratory rate is greater than the FGF the bag begins to empty (Fig. 5.8A).

• Expiration. During expiration, the exhaled gasses mix with fresh gas entering the system and these pass down the wide bore hose. They initially displace any fresh gas remaining here and start to fill the reservoir bag (Fig. 5.8B). When the bag is full, the remainder of the exhaled gasses and the FGF are voided via the APL (expiratory) valve. Of the expired gasses, it is those from the patient’s respiratory dead space that are voided first, followed by alveolar gasses.

• End-expiratory pause. During the end-expiratory pause the fresh gas flow entering the system passes down the wide bore hose, displacing some of the mixture of exhaled gas and FGF, which is now vented out through the APL valve (Fig. 5.8C). The amount of fresh gas occupying and thus stored in the patient end of the wide bore hose at the end of expiration, therefore depends on the fresh gas flow rate, the duration of the end-expiratory pause, and the degree of mixing (due to turbulence) of the various gaseous interfaces within the corrugated hose.

• At the next inspiration the inhaled gasses consist initially of this stored fresh gas followed then by the mixture of exhaled gasses and FGF that remain in the tube and possibly some of the mixture from the reservoir bag if the inhaled tidal volume is large (Fig. 5.8D).

However, there are practical problems with this concept, since the expiratory pause may be short, particularly during spontaneous breathing (when volatile anaesthetics only are used with minimal opioid supplementation). In this case the fresh gas flow needs to be sufficiently high to flush the exhaled gasses downstream prior to the next inspiration. In fact, rebreathing of exhaled alveolar gas occurs unless the fresh gas flow is at least 2 times and possibly up to 4 times the patient’s minute ventilation.

It is worthy of note that the Mapleson D system is functionally similar to a T-piece (Mapleson E). However, with a T-piece, the limb through which the ventilation occurs, if used without a reservoir bag, must be of such a length that the volume of gas in it when augmented by the volume of the fresh gas flow being delivered during inspiration is no less than that of the patient’s tidal volume, otherwise dilution of anaesthetic by entrained air will occur.

Mapleson D system with controlled or assisted ventilation

Thus, to prevent rebreathing in the Mapleson D system during both spontaneous and controlled ventilation, the fresh gas flow must be sufficiently high enough to:

However, in practice during controlled ventilation, deliberate use is often made of functional rebreathing. Theoretically, if slow ventilation rates (with long expiratory pauses) and large tidal volumes are chosen, then sufficient expiratory time will elapse to allow a modest fresh gas flow to fill the proximal part of the system with sufficient fresh gas to provide alveolar ventilation. This will enter the lungs first, followed by a mixture of previously expired gasses which will then occupy the patient’s anatomical dead space. Hence, theoretically, it should be possible to reduce the fresh gas flow to the volume required for alveolar ventilation.

In practice, there is turbulent mixing of the various gaseous interfaces so that alveolar gas is widely distributed (and diluted). Even so, provided sufficiently large controlled minute ventilation is delivered so that most of the fresh gas flow reaches the alveoli, adequate alveolar ventilation will occur with fresh gas flow rates of 70% of the anticipated minute ventilation since, as mentioned above, some rebreathing is acceptable. Fig. 5.10 demonstrates this as well as the fact that the arterial carbon dioxide tension remains fairly constant for any given fresh gas flow rate despite alterations in minute ventilation.

Mapleson D systems are thus able to make efficient use of fresh anaesthetic gasses during controlled ventilation and could have considerable cost saving benefits. Fig. 5.11 shows how the Mapleson D system may be employed with an automatic ventilator. The reservoir bag is removed and replaced with a standard length of corrugated hose of sufficient capacity to accommodate the air or oxygen that is delivered by the ventilator, and therefore prevents it reaching the patient in place of the intended anaesthetic gasses.

The Bain system

The Bain breathing system (Fig. 5.12) is similar in function to the Mapleson D system. The only difference is that the fresh gas flow is carried by a tube within the corrugated hose (a co-axial arrangement). In the earlier models in particular, there was a risk that the inner tube could become disconnected at the machine end; if this happened a very big dead space was introduced. It could also become kinked, so cutting off the supply of fresh gasses.

Hybrid systems

A number of breathing systems have been described that, by means of a lever switch, can convert the system from a Mapleson A to a Mapleson D or E, allowing a system to be chosen and used in its most efficient mode (i.e. system A, spontaneous respiration; system E, controlled respiration). The Humphrey ADE system (Anaequip) seems to be the most popular version (see Fig. 5.13A). A ‘Y’ shaped length of corrugated breathing hose is attached to H and F in the diagram with the short limb of the Y at the patient.

With the lever up in the A mode (Fig. 5.13B), the reservoir bag on the ADE block is connected to the inspiratory pathway as in a Mapleson A system. The breathing hose connecting the block at H to the patient is now designated as the inspiratory limb. Expired gas is carried back along the other limb to the block at F and then is vented through an APL valve which is shrouded to facilitate scavenging. In practice it appears to function more efficiently than a traditional Magill attachment. The improved efficiency is thought to relate to the position and design of the components at the patient end of the system. Towards the end of exhalation in a Magill attachment, the exhaled dead-space gas which has passed up the breathing hose is now returned towards the APL valve by the flushing action of the fresh gas flow entering the system. At the APL valve, it meets and mixes with alveolar gas in turbulent fashion, and a mixture of both is discharged from the valve. However, in the Humphrey (and Lack) systems alveolar gas is diverted in a more laminar fashion into a physically separate expiratory limb, which minimizes any potential for mixing of the two gas phases in question. This arrangement, and the removal of the APL valve assembly away from the patient end of the system, also reduces apparatus dead space, so that with further modification (see below) it may be suitable for infants and neonates.

With the lever down in the D/E mode (Fig. 5.13C), the reservoir bag and APL valve are isolated from the breathing system. What was the ‘inspiratory’ limb in ‘A’ mode now delivers gas to the patient end of the system as in a T-piece (see below). The breathing hose returning gas to the ADE block now functions as the reservoir limb of a T-piece. This hose vents to atmosphere via a port adjacent to the bag mount. As this mode does not incorporate a reservoir bag, it is strictly a Mapleson E system. The port described above is usually connected to a ventilator of the ‘bag-squeezer’ type (see Chapter 9), so that the system can be used in its most efficient mode for controlled ventilation.

The Anaequip version is supplied with 15 mm smooth bore non-kinking breathing hose and a unique APL valve (see later in chapter). Interestingly, the use of this smooth bore hose reduces turbulence in the range of flows seen in quietly breathing adults, so that its performance is little different from that of 22 mm corrugated hose. The narrower bore hose also reduces the internal volume of the system to an extent that it is now also suitable for use with infants. A low internal volume is important in a paediatric breathing system in order that:

Mapleson E and F systems

The T-piece system

When what are now termed APL valves were first made, they offered a resistance to exhalation, which was deemed unacceptable in certain anaesthetic techniques such as those used for neonatal and infant anaesthesia. This distinction has become less important (see Chapter 12). To avoid this resistance, the T-piece system was designed by Philip Ayre in 1937. In Fig. 5.14 the fresh gasses are supplied via a small-bore tube to the side arm of an Ayre’s T-piece. The main body of the T-piece is within the breathing system and must, therefore, be of adequate diameter. One end of the body is connected by the shortest possible means to the patient. (The volume of this limb makes up apparatus dead space.) The other end is connected to a length of tubing that acts as a reservoir.

In the case of spontaneous ventilation, the FGF rate must be high. During inspiration the peak inspiratory flow rate is higher than the FGF, so some gasses are drawn from the reservoir limb. During expiration both the exhaled air and the fresh gasses, which continue to flow, pass into the reservoir limb and are expelled to the atmosphere. During the end-expiratory pause the FGF flushes out and refills the reservoir limb. The dimensions of the reservoir limb and the FGF rate are governed by the following considerations:

The shape of the T-piece is also important. Normally the side arm is at right angles to the body. If it is at an angle pointing towards the patient, there is continuous positive pressure applied which would act as a resistance during expiration; similarly, if the gasses were directed towards the reservoir, a sub-atmospheric pressure would be caused by a Venturi effect. As mentioned previously this continuous positive airways pressure is thought to be beneficial in minimizing the fall in functional residual capacity (FRC), especially in neonates.

Non-rebreathing systems utilizing carbon dioxide absorption and recirculation of gasses

High flows of inhalation anaesthetic agents (i.e. at least approximately equal to the patient’s minute ventilation) are regularly used with most breathing systems at the beginning of an anaesthetic for the following reasons:

However, when equilibrium between the patient’s blood and inspired concentration of anaesthetic has been reached, this inspired concentration is exhaled relatively unchanged, and so the main function of high fresh gas flows in most breathing systems is the elimination of carbon dioxide (whilst at the same time providing oxygen!).

Thus to continue a high FGF after equilibrium has been achieved is both wasteful and expensive, and, in addition, may increase theatre pollution. This exhaled gas at near equilibrium can be reused in suitable systems if it is purged of exhaled carbon dioxide, and has the oxygen concentration restored (oxygen is always removed from the inspiratory mixture by the lungs at a rate between 120 and 250 ml min). The re-utilization of suitably modified exhaled gasses can thus reduce the fresh gas flow to very low levels (see below).

Carbon dioxide absorption

Carbon dioxide can be removed from exhaled gasses by a chemical reaction with various metallic bases (hydroxides). This reaction requires the presence of water in order that these bases and carbon dioxide (as carbonic acid) can exist in ionic form.

Chemical composition of absorbents

The main constituent of absorbents made by different manufacturers is calcium hydroxide. Other constituents may be added to enhance the reactivity. These include the following:

Other constituents

Production

The ingredients are mixed along with added water into a paste. This is treated in a number of ways. Originally the paste was dried and then crushed between rollers so that it formed granules. The product was then sieved through various meshes to retain the sizes quoted above. The dried granules were then sprayed with water to give the right amount of water content to allow optimal reactivity without making the granule soft or sticky. Mesh standards differ between countries due to variations in thickness of the wire used to construct the mesh. In the USA soda lime granules are supplied at between 4 and 8 Mesh USP (2.36–4.75 mm). In the UK the granules are supplied to a BP (British Pharmacopoeia) standard of 1.4–4.75 mm (3–10 Mesh). More recently, production methods have been introduced that produce a more uniform size. The paste may be squeezed through a sieve like spaghetti and chopped into little pieces. It may be passed through a mangle that has thousands of dimples on its surface. This produces tiny similar-sized spheres that are blown off the roller by a high-pressure jet of air. The paste may also be placed on a dimpled belt that is passed through a smooth roller. This produces little hemispheres that are removed from the belt in a manner similar to removing an ice cube from its tray.

The dust is caustic and can produce burns in the respiratory tract if inhaled. This was a problem with the older type of system with ‘to-and-fro’ absorption (Waters’ Canister, see below), where the absorber was placed in close proximity to the patient’s airway. However, circle absorbers are usually separated from the patient by at least 1 m of breathing hose, which normally hangs in a loop. This allows the dust, if present, to fall out before it call get to the patient. Furthermore, a breathing filter separating the patient from the breathing system would protect against this.

The exothermic reaction

The heat and water produced by the reaction of absorbent on carbon dioxide has been considered to be beneficial in that (at low flows) they warm and partially humidify the inspiratory gas. The temperature and humidity of the inspired gas is related to a number of factors:

The heat produced, however, is not necessarily all beneficial. The chemical reaction between volatile anaesthetic agents and absorbents containing sodium or potassium increases in proportion to the temperature within the system:

Dry barium lime, which contains potassium hydroxide, has a much greater tendency to produce carbon monoxide than dry soda lime that contains sodium hydroxide. Fresh absorbent, which has an approximately 15% water content, appears to prevent carbon monoxide formation. In fact significant production takes place only when the water content drops below 2%. The problem can occur when the absorber is left unused for long periods, or when large amounts of dry gas are allowed to pass through it between cases, particularly overnight or at weekends. Even with the flow meters turned off, this is seen albeit after a long period of time in some anaesthetic machines, if:

Carbon monoxide is not easily measured as an exhaled gas as it binds to haemoglobin in the blood first. Its production in a system using absorbents may be difficult to detect. There is not necessarily a colour change in absorbents containing strong bases (potassium/sodium) if they dry out! Suspicion should be raised if there appears to be excessive heat production from the absorbent. This phenomenon can easily be avoided by:

Sevoflurane may undergo degradation within the absorber, to non-toxic fluorinated metabolites in humans (mainly a sevo-olefin called ‘compound A’). Levels rise, as would be expected, with increased concentration of the agent, prolonged anaesthesia, low fresh gas flows and increased operating temperature within the absorber. However, there is no evidence of any danger to humans. In the presence of dried absorbent (especially barium lime) there may be an extreme temperature rise and a number of other breakdown products are produced including formaldehyde and methanol. There have been isolated reports of fire or extreme heat in circle systems resulting in at least one fatality. This prompted the manufacturer to issue a letter to healthcare professionals in the USA warning of the danger. In the cases investigated the following signs were noted:

In summary the recommendations for preventing the problem are as follows:

It is worth noting that as a result of increased awareness and the availability of safer absorbents, there have been no reported incidents of any of the problems discussed above since the year 2000.

Classification of breathing systems utilizing carbon dioxide absorption

Carbon dioxide absorption can be used in two types of system:

’To-and-fro’ absorption systems

The Waters’ canister (Fig. 5.16)

Here the patient breathes in and out of a closed bag, which is connected to the facemask or endotracheal tube via a canister containing soda lime. The part of the system between the patient and the soda lime is dead space and, therefore, its volume must be kept to a minimum. This means that the soda lime canister must be close to the patient’s head, and this leads to practical difficulties. A length of wide-bore tubing may, however, be interposed between the canister and reservoir bag without detriment. The fresh gasses are introduced at the patient end of the system, and the expiratory valve is usually mounted close by, though it may equally well be put at the bag end. The canister is usually placed in the horizontal position for convenience, and it is most important that it is well packed, since if there were a space above the soda lime, ‘channelling’ would occur and absorption would be incomplete (Fig. 5.17A).

Furthermore, the absorbent at the patient end of the system becomes exhausted first and so increases the functional dead space of the system.

Canisters are available as pre-packed, disposable units. In those intended for reuse, the absorbent may conveniently be compressed to prevent gaps by the insertion of a spongy ‘spacer’ at one end (Fig 5.17B). When the canister is closed, the sealing washer should be checked to ensure that it is in the correct position and any soda lime on the threads of the canister or the sealing washer should be carefully removed as these may cause leaks. The whole system should be tested before use.

Apart from being cumbersome, the ‘to-and-fro’ system has the disadvantage that the patient could inhale absorbent dust. A breathing filter should be inserted in the patient end of the canister to prevent this.

Circle absorption systems

Here the disadvantages of the absorbent canister being so close to the patient are avoided. The patient is connected to the absorber by two corrugated hoses, one inspiratory and the other expiratory, as shown in Fig. 5.18A. The one way or ‘circle’ flow of gasses through the system is determined by two unidirectional valves V1, and V2, which are accommodated in transparent domes so that their correct action may be observed.

The fresh gas port and the reservoir bag may be sited in the inspiratory pathway close to the inspiratory valve V1 or in the expiratory limb of the system downstream of the valve V2. There are claimed advantages for each arrangement. Positioning the FGF and bag in the inspiratory pathway may reduce the resistance to inspiratory effort and prevents desiccation of the absorbent if the fresh gas flow is left on for long periods when the system is not in use. This has implications for the efficiency of the absorbent and its potential for producing unusual breakdown products (see above). However, positioning the FGF and bag in the expiratory limb so that the FGF passes through the absorbent before reaching the patient allegedly warms and humidifies this gas. This also seems to remove some of the excess moisture often seen in absorbers that might increase resistance through the system. The APL valve is usually mounted downstream of the valve V2 (position ‘B’) in the expiratory limb, but before gas entry into the absorber. Here, it can dump excess exhaled gas prior to entry of gas into the absorber. At one time it was considered that an APL valve was best positioned in the breathing system at position ‘A’ for use with spontaneous respiration (Fig. 5.18A). This would preferentially dump alveolar gas during exhalation, thus increasing carbon dioxide elimination upstream of the absorber and conserving soda lime. However, as scavenging assumed a greater importance, the inconvenience of connecting a cumbersome scavenging hose to a valve in this position has limited its usefulness.

Circle breathing systems are manufactured in many different designs and sizes. Most are two part systems with one part comprising a fixed body containing the gas pathways, switches, valves and the other a detachable canister that contains the absorbent. Figs 5.18B, C and D show commercial versions of the system described. Fig. 5.18B (circle system for ADU anaesthetic machine, Datex-Ohmeda) has a container for 1 kg of absorbent that may be either disposable or refilled. During replacement, self-sealing valves on the body of the unit close to prevent escape of patient gas from the rest of the system. Figs 5.18C and D show other types of 1 kg and 2 kg absorber respectively. The rationale for larger absorbers is discussed below.

The system shown in Figs 5.19A and B is a disposable version. The valve V1 is sited in the breathing hose and as close to the patient as possible. In this position it is alleged to have a faster response to pressure changes caused by exhalation and closes earlier, although, as it is exhaled dead space gas that enters the system first, it is immaterial as to which limb this enters initially. Unlike many circle systems that are now an integral part of the anaesthetic workstation, the APL valve is not automatically excluded from the system in mechanical ventilation mode. Therefore, when a ventilator is attached to the reservoir bag port and is in use, the APL valve must be closed fully or gas will be lost from the system.

Efficiency of absorbers

The efficiency of carbon dioxide absorption in a canister depends on:

Early canister designs contained approximately 480 g of absorbent. These required frequent changes (after approximately 2–2.5 h of continuous use at low fresh gas flows). Many presently used absorbers are of the ‘Jumbo’ type, which contain 2 kg of soda lime and, since this has a large volume and surface area of granules, the expired gas is in contact with them for a relatively long period of time, so increasing the efficiency of absorption. It has been shown that a 2-kg canister lasts five times longer than a 0.5-kg canister. When a 2-kg canister is employed it usually has two chambers, one above the other. When one half appears exhausted it is refilled and the canister positions reversed so that the previously unused half now bears the brunt of absorption. Not only is the absorption more efficient in the larger absorbers, but also less frequent recharging is necessary.

With the recent introduction of routine expired carbon dioxide monitoring, these last two considerations appear to be less of a problem in clinical practice, and the reintroduction of smaller absorbers may well have advantages. These are easier to maintain, use and keep clean, and they have fewer leaks and are less prone to causing degradation of volatile agents (see above). The absorbent can also be supplied in disposable cartridges (see Fig. 5.18B).

The use of ventilators with circle systems

Any ventilator deemed suitable for use with a circle system must have the following features:

There are three types of ventilator that are used to drive circle systems: ‘bag squeezer’, pneumatic piston and turbine.

‘Pneumatic piston’

Here, the reservoir bag is replaced by a suitably long length of breathing hose. The driving gas from the ventilator is passed through a special valve (Figs 5.21A and B) into the breathing hose. The latter is sufficiently long so that its internal volume is at least 1.5–2 times greater than the patient’s tidal volume and prevents the driving gas from entering the circle and contaminating the patient gas. This is especially important in many circle systems where the reservoir limb is sited in the inspiratory pathway. Here, driving gas could dilute the inspiratory anaesthetic gas sufficiently to cause an inadequate level of anaesthesia to be maintained.

Maintenance of circle absorber systems

Prior to the routine use of breathing filters and during prolonged use of the absorber at low fresh gas flow rates, water vapour from exhaled gasses and from the absorbent would condense in the expiratory hose and this needed to be emptied from time to time. Condensation also settled on the unidirectional valves which occasionally caused the valve disc to either adhere by surface tension to the seating or to the cage holding it in place. The former increased flow resistance and the latter allowed rebreathing of CO2. Nowadays, exhaled water vapour does not usually pass back through the breathing filter into the circle system and this does not seem to pose the same problem.

In parts of the world where the cost of single-use breathing filters would be prohibitive, the tubing should be autoclaved if suitable or washed and hung out to dry between cases. Secondly, the expiratory valve should be dismantled and wiped clean with isopropyl alcohol. When, after dismantling, the glass dome of the expiratory valve is screwed back on again, it is important to ensure that the sealing washer is correctly in place, otherwise a serious leak may occur. If a low-resistance bacterial filter is not used, then the circle absorber housing should be autoclaved (where possible) on a regular basis. Some circle absorbers cannot be autoclaved, but may be cleaned by chemical means.

The absorbent should be changed at regular intervals either when:

The container for the absorbent usually has a mark above which it should not be filled. Overfilling may result in granules of absorbent clogging the threads of canisters that screw into position, or may prevent the correct seating of the sealing washer, thus causing a leak or bypassing of the absorbent. Furthermore, leaving this space at the top reduces the preferential ‘channelling’ effect of the gas stream along the sides, and ensures a more even flow through the container. Since the canister is held in the vertical position, channelling is less of a problem than in the Waters’ canister, although some does occur between the granules and sides of the canister as the air spaces here are bigger than those between granules within the canister.

Gas and vapour concentration in a circle system

Circle systems are unique in that they function effectively (when a steady state of anaesthesia has been reached) using a wide variety of fresh gas flow rates. However, the fate of the various gasses within the system needs to be understood in order that it may be used safely and effectively. For example, the internal volume of the apparatus (when using a 2 kg absorber, which consists of the inter-granular air space in the absorber (1 L), the breathing hoses (1 L) and pathways within the absorber (1 L), totalling 3 L, along with the functional residual capacity of a patient of 1.25 L, provides a large reservoir into which the anaesthetic gas is diluted at the beginning of anaesthesia.

In order to minimize this dilution and provide adequate concentrations of anaesthetic agent, high flows of fresh gas and vapour are required initially in order to flush the residual gas out of the circle system; the higher the flow, the faster this ‘wash out’ occurs. Lung ‘wash out’ will of course depend on the patient’s minute ventilation. The greater this is, the less time the process takes.

Secondly, the alveolar uptake of anaesthetic agent is greatest at the beginning of anaesthesia. Therefore, the higher the initial fresh gas flow rate (up to a value equal to the patient’s minute ventilation) the greater is the delivery of anaesthetic agent into the system. This in turn minimizes any reduction in concentration of agent caused by uptake by the patient. When a near equilibrium of anaesthetic agents in the alveoli and the blood has been reached, exhaled agent concentration almost equals that in the inspiratory mixture, and, therefore, the high initial fresh gas flows may be greatly reduced safely.

In practice the fresh gas flow is usually reduced in stages.

Oxygen concentrations in circle systems at low fresh gas flows

As the fresh gas flow in a circle is decreased, exhaled gas that is allowed to recirculate exerts an increasing influence on the subsequent inspired gas mixture. The oxygen concentration of this exhaled gas depends on:

Fig. 5.22 shows the decrease in alveolar oxygen concentrations of a 50% nitrous oxide and 50% oxygen mixture under controlled conditions. It can be seen that at a FGF of 1 l min−1 if there is no longer any nitrous oxide uptake, the oxygen concentration has dropped to 27% and drops even further at a FGF of 0.5 l min−1. Therefore, in clinical practice the oxygen concentration in a circle at low flows is unpredictable and monitoring of inspired oxygen with an analyzer is essential. In fact, monitoring of all gasses and anaesthetic vapours should be considered mandatory for circle systems at low flows.

Vaporizer outside circle

This is probably the most common method of introducing inhalational agents into the breathing system. At high fresh gas flows, the vapour concentration in the circle is reliably represented by the dial setting of the vaporizer. However, as the FGF is reduced two phenomena occur:

At low FGFs, and in the absence of a vapour analyzer, therefore, the anaesthetist would need to know:

The lower the FGF, the more difficult it is to predict the inspired concentration of agent. At flows below 2 l min−1 it is essential to incorporate a vapour analyzer into the system, especially during controlled ventilation when signs of light anaesthesia may be more difficult to determine, to ensure that adequate amounts of agent reach the patient.

Vaporizer in circle

If the vaporizer is incorporated into the circle system, it must have a low resistance to gas flow so as to minimize the respiratory work required of a spontaneously breathing patient. High-resistance plenum vaporizers are unsuitable.

With a vaporizer incorporated in the circle, recirculating gas picks up vapour to add to the vapour that is already being carried, and, therefore, the vapour concentration may well be greater than intended. Calibration of vaporizers in this system is, therefore, impossible. The vapour concentration in this type of system depends on a number of factors when equilibrium has been reached:

Therefore, for potent agents, an inefficient vaporizer is preferable. The presence of a wick in a vaporizer in the circle is also unsuitable, since water vapour will condense on the wick, reducing its efficiency and possibly increasing the resistance to gas flow.

Ether, for which much higher concentrations are appropriate, has, however, been widely and safely used with a VIC. Adequate vaporization may be assisted by the use of baffles within the vaporizer that cause the gasses to impinge repeatedly on the surface of the ether, or even by bubbling the fresh gas flow through the liquid ether. It may also be increased to some extent by the heat from the recirculating expired gasses.

Procedures for checking breathing systems

All the breathing systems described above will only function correctly if the components are free of any fault, assembled in the correct order and the connections made gas-tight. A good working knowledge of the apparatus is essential prior to its use by a practitioner. Fatalities have, unfortunately, occurred where the user:

Therefore, all systems should be checked prior to each use according to the manufacturer’s instructions or against a checklist approved by a hospital department or a national association (e.g. the Association of Anaesthetists of Great Britain and Ireland). A suitable inspection should ensure that:

In addition to this, any co-axial breathing system should have the integrity of the inner limb confirmed. This can be done on a Mapleson D system by occluding the inner limb only (e.g. with an appropriately supplied tool or a 1 ml syringe), observing that the bag remains deflated and that the anaesthetic machine safety valve protecting the back bar gives an alarm signal. With a Mapleson A system (Lack co-axial), occluding the inner limb only should cause the reservoir bag to distend (with the APL valve closed).

The components of a breathing system

Rebreathing and reservoir bags

Rebreathing and reservoir bags (Fig. 5.23) are identical, the distinction being solely in the use to which they are put, as explained previously. The commonly used size in adult breathing systems is 2 L (i.e. that which when fully, but not forcibly, distended has a capacity of 2 L; in clinical practice it is seldom filled beyond this capacity). They are also available in 1 L and 0.5 L sizes for paediatric anaesthesia. Larger bags are sometimes used as reservoir bags in ventilators.

In adult breathing systems, the capacity to which the bag may easily be distended must exceed the patient’s tidal volume. A larger capacity, bag (2 L), however, is safer as it more easily absorbs pressure increases. The neck of the bag is stretched over a female 22 mm metal or plastic tapered connector. A metal or plastic cage is often attached to the part of the connector that fits inside the bag. This prevents the inlet from being occluded if the bag were folded.

In the Jackson Rees T-piece paediatric attachment, a double-ended bag is added to the expiratory limb (Fig. 5.24) and the smaller end acts as an expiratory port, the aperture of which can be controlled by the anaesthetist.

The material of which a breathing system bag is constructed is important. Where ventilation is spontaneous, the opening pressure of the expiratory valve must exceed that required to prevent the bag from emptying spontaneously owing to its weight or resistance to distension. Therefore, to maintain a low expiratory pressure, the bag must be ‘soft’. This was achieved easily when natural latex rubber bags were in common use. The increase in latex allergy in the general population and in healthcare workers has had a major impact on the provision of equipment that had previously contained natural latex rubber. All anaesthetic equipment in the UK is now supplied with natural latex-free parts. These include ventilator bellows and reservoir bags. The latter are made from synthetic compounds such as polychloroprene (neoprene, a synthetic latex rubber). Some manufacturers make their bags sufficiently pliant to mimic the elasticity of natural latex. These will distend well-beyond their normal filling capacity until they burst, but the pressure in the bags will stay below 60 cm H20. This is thought to be a safety feature that prevents barotrauma to a patient’s lungs should the exhalation pathway in a breathing system containing this bag become occluded. This would be caused most commonly by an APL valve inadvertently screwed shut. Some, however, are made from less compliant material and the pressure may rise to over 60 cm H20. These bags should be fitted only to breathing systems that have a pressure relief valve attached either as a separate feature or built into the APL valve (see below).

The observed movement of the bag depends on several factors, such as its shape, size, degree of filling, the tension of the expiratory valve and the fresh gas flow rate, as well as on the patient’s tidal volume. An accurate estimate of the patient’s tidal volume cannot be made simply by watching the bag.

Adjustable pressure limiting (APL) valves

The purpose of this valve is to allow the escape of exhaled (expired) and surplus gasses from a breathing system, but without permitting entry of the outside air, even during a negative phase. Usually it is desirable that the pressure required to open the valve should be as low as possible, in order to minimize resistance to expiration. It must, however, present sufficient resistance to prevent the reservoir bag from emptying spontaneously, particularly when a scavenging system is employed that exerts a slight sub-atmospheric pressure upon it.

The operating principles of APL valves are based on the Heidbrink valve (Fig. 5.25). The valve disc is as light as possible, and rests on a ‘knife-edge’ seating that presents a small area of contact. This lessens the tendency to adhesion between the disc and seating due to the surface tension of condensed water from the expired air, or after washing or sterilizing. The disc has a stem that is located in a guide, in order to ensure that it is correctly positioned on the seating, and a lightweight coiled spring, which promotes closure of the valve.

The spring is a delicate coil and is of such dimensions that when the valve top is screwed fully ‘open’ there is minimal pressure on the disc when seated. However, during the ‘blow-off’ phase the disc rises and shortens the spring so that the pressure it exerts on the disc is greater and will close it at the appropriate time. Screwing down the valve top produces progressively increasing tension in the spring. When the top is screwed down fully, the valve is completely closed. The valve should always be used in the vertical position so that the disc is seated by gravity.

The Humphrey APL valve

An interesting addition to the standard APL valve is the modification seen on the version (Figs 5.13 and 5.26) that is part of the Humphrey ADE system. Here, the valve disk is attached to a red-coloured spindle that extends through the valve top. When the valve is fully open, the spindle is seen to bob up and down as the disk is lifted up and down during respiration. The valve top is made concave and shiny so that it reflects and magnifies the spindle colour so as to detect even the smallest movement when used in paediatric anaesthesia. The inside of the valve body has a small funnel through which the disk has to move before significant gas can escape. This initial movement of 5 mm accentuates the bobbing action of the spindle which is useful particularly in paediatric anaesthesia.

When the ADE system is used in the Mapleson ‘A’ mode, the valve spindle may be held down with a finger if switching from spontaneous to manual ventilation is required. This has a number of advantages:

It was originally thought that the increased respiratory work produced by the expiratory resistance of APL valves was detrimental to anaesthetized patients. This is without doubt true when the valve resistance is high (due to sticky valves, narrow valve apertures) or where the respiratory effort is severely compromised (e.g. in neonates). However, modern valve design (with wider valve apertures, lighter valve discs, more delicate springs, better screw threads) minimizes this resistance. Furthermore a small PEEP (positive end expiratory pressure) effect that these valves may produce is now thought to be positively beneficial, reducing the potential for the functional residual capacity of the lungs to fall below the closing volume in supine anaesthetized patients.

APL valves with in-built overpressure safety devices

Any unexpected pressure rise in a breathing system was made relatively safe by the compliance of the latex rubber of the reservoir bag. This could still fail, for instance if the bag were trapped under the wheel of an anaesthetic machine, a dangerously high pressure could develop within the breathing system and be passed on to the patient. Now that latex rubber is no longer used owing to the increase in latex allergy, new materials are used that may not have the same elasticity and so are not as compliant. This safety feature can no longer be relied on. APL valves are now available in which an overpressure safety device has been incorporated.

An example, is shown in Figure 5.27.

It has two valves:

When the valve top (1) is unscrewed fully (Fig. 5.27A), the outer valve is permanently open, but the inner one is closed until exhaled gas forces it open. The pressure required to do this is small (0.15 kPa /1.5 cm H2O). As the valve is gradually closed, the expiratory flow resistance increases and in sophisticated examples this resistance can be calibrated and displayed on the valve body. When the valve top is screwed down fully, both valves are closed and in this position the outer one is pushed against the inner so that is has no movement of its own (Fig. 5.27B). An excess pressure is now required to move the more powerful spring on the outer valve which will begin to open at 3 kPa (30 cm H2O) and be fully open between 6 and 7 kPa (60–70 cm H2O) when the gas flow is 50 l min−1 (Fig. 5.27C). Fig. 5.27D is an example of a calibrated APL valve incorporating an overpressure safety valve set at 70 cm H2O.

Alternative APL valve design

Many breathing systems are now supplied as single use items. This includes the APL valve (Fig. 5.28A). It is now possible to simplify the design so that the spring and the valve disc are replaced by a neoprene flap valve (1) (Fig. 5.28Bi). This opens and shuts in the normal manner during spontaneous respiration. When positive pressure is required, the valve top (2) operates a screw threaded insert (3) that lowers an overpressure relief valve (4). As the valve top is screwed shut, the insert lowers the second valve (4) onto the flap valve housing, gradually occluding the expiratory pathway until complete occlusion occurs (Fig. 5.28Bii). The second valve is fitted with a spring (5) which is strong enough to maintain the occlusion up to a pressure of 60 cm H2O, but weak enough for the valve to lift (Fig. 5.28Biii) and allow gasses at a higher pressure to escape.

Breathing hoses

The hoses connecting the components of a breathing system must be of such a diameter as to present a low resistance to gas flow. Its cross-section must be uniform to promote laminar flow where possible and, although it should be flexible, kinking should not occur.

The most commonly used type was for a long-time, corrugated hose of rubber or polychloroprene (neoprene). The corrugations allow acute angulations of the hose without kinking. The advantage of these materials is that the ends are more easily stretched, and will make a good union with other components of different diameters. They may be sterilized by steam autoclaving and be reused in countries where single-use alternatives are impractical. The disadvantages are that the irregular wall must cause turbulence and being opaque may harbour dirt and infection unseen. They are also heavy and, if unsupported, may drag on a facemask or endotracheal tube.

Various other materials such as silicone rubber and plastics (polyethylene) are in use, both in corrugated and smooth form (Fig. 5.29). Smooth bore breathing hose produces less turbulence than the corrugated variety at similar gas flows. It can also be produced so that it resists kinking (by the attachment of a reinforcing spiral of a similar material to its external surface). With smooth bore hosing, a smaller diameter (e.g. 15 mm) may well be acceptable for use with adult breathing systems (see Humphrey ADE breathing system).

Plastic hosing has become very popular because it is lightweight, cheap to manufacture, and, therefore, disposable. Some are supplied as complete breathing systems (Figs 5.12 and 5.19) or in long coils, the appropriate length of which may be cut off at one of the frequent intervals where the corrugations (Fig. 5.30) give way to a shaped connector. More recently, the addition of small quantities of silver mixed with the plastic (Silver Knight) has been used to make breathing systems bactericidal both on the inside and the outside of the hosing.

Silicone rubber hosing is autoclavable, unlike many plastics that would melt if so treated. Plastic apparatus intended for single use only is normally sterilized at manufacture by gamma irradiation.

There are several standard sizes of corrugated hose, both ends of which have smooth walls for about 2–3 cm. These ends are designed to fit either tapered connectors (see below) or tapered components of a breathing system. The breathing hose for adult use is normally 22 mm wide so as to reduce the resistance to breathing to a minimum. Paediatric breathing hose has a narrower bore (15 mm) to reduce its internal volume (see Chapter 12) and to make it less cumbersome.

Tapered connections (adapters)

Tapered connections (adapters) provide a useful way of joining rigid tubes or other components together in such a manner that the joint will not leak. The joint is described as having a male half and a female half that are pushed together with a slight twist to form a gas-tight fit. The joint may be easily dismantled and reassembled, a feature that makes it useful for the interconnection of breathing systems, catheter mounts and endotracheal connectors.

A leak-proof joint relies on its components being completely circular and having the same angle of taper so that the maximum contact between the components of the joint will occur. The standard also requires that male tapers for breathing systems be fitted with a recess behind the taper so that when rubber and plastic hosing is pushed on to a male connector, its leading edge can contract into this recess to provide a more secure fitting.

Examples of tapers are shown in Figs 5.31A and B.

The current ISO and BS recommendations on the sequence of tapers in various breathing systems are set out in Fig. 5.32.

Prior to the introduction of any standards, manufacturers were free to decide the size and angle of tapers used with their equipment. However, there is now an internationally agreed size for tapered connections for use with anaesthetic breathing systems and endotracheal tubes so that there is compatibility between equipment from different manufacturers.

The International Standards Organization (BS EN ISO 5356-1: 2004, Anaesthetic and respiratory equipment – Conical connectors – Part 1: Cones and sockets) specifies the use of:

Some 22 mm male breathing hose connections are so manufactured that they incorporate a 15 mm female taper for direct connection to an endotracheal tube.

It is worthy of note that the current British Standard requires that a reservoir bag should have a female inlet to fit the male outlet for bag mounts on all breathing systems. However, should a length of breathing hose be required between the bag mount and reservoir bag, a problem arises. The breathing hose is manufactured with two female ends. One will fit the bag mount (male to female) but the other will not fit the bag (female to female). A male to male 22 mm tapered adapter is required (see Fig. 5.31).

Further reading

Carbon monoxide and compound A formation

Baum JA, Woehlckhemical JH. Reaction interaction of inhalation anaesthetics with CO2 absorbents. Best Pract Res Clin Anaesthesiol. 2003;17:63–76.

Baxter PJ, Garton K, Kharasch ED. Mechanistic aspects of carbon monoxide formation from volatile anesthetics. Anesthesiology. 1998;89:929–941.

Cunningham DD, Huang S, Webster J, Mayoral J, Grabenkort RW. Sevoflurane degradation to compound A in anaesthesia breathing systems. Br J Anaesth. 1996;77:537–543.

Fang ZX, Eger EI, 2nd. USCF Research shows that CO comes from CO2 absorbent. Anaesth Patient Saf Found Newsl. 1995;9:26–29.

Fang ZX, Eger EI, 2nd., Laster MJ, Chortkoff BS, Kandel L, Ionescu P. Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane, and sevoflurane by soda lime and Baralyme. Anesth Analg. 1995;80:1187–1193.

Funk W, Gruber M, Wild K, Hobbhahn J. Dry soda lime markedly degrades sevoflurane during simulated inhalation induction. Br J Anaesth. 1999;82:193–198.

Harrison N, Knowles AC, Welchew EA. Carbon monoxide within circle systems. Anaesthesia. 1996;51:1037–1040.

Knolle E, Heinze G, Hermann G. Small carbon monoxide formation in absorbents does not correlate with small carbon dioxide absorption. Anesth Analg. 2002;95:650–655.

Knolle E, Linert W, Gilly H. The color change in CO2 absorbents on drying: an in vitro study using moisture analysis. Anesth Analg. 2003;97:151–155.

References Medicines Control Agency Drug Alert 1995 (N31 May EL(95) (ALERT) A/17) Important precautions required when using halogenated anaesthetic agents. 1995;78:340–8.

Stabernack CR, Brown R, Laster MJ, Dudziak R, Eger EI, 2nd. Absorbents differ enormously in their capacity to produce compound A and carbon monoxide. Anesth Analg. 2000;90:1428–1435.

Strum DP, Edmond I, Eger II. Degradation, absorption and solubility of volatile anaesthetics in soda lime depend on water content. Anesth Analg. 1994;78:340–348.

Struys MM, Bouche MP, Rolly G, Vandevivere YD, Dyzers D, Goeteyn W, et al. Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents. Anaesthesia. 2004;59:584–589.

Woehlck HJ, Dunning MB, 3rd., Kulier AH, Sasse FJ, Nithipataikom K, Henry DW. The response of anesthetic agent monitors to trifluoromethane warns of the presence of carbon monoxide from anesthetic breakdown. J Clin Monit. 1997;13:149–155.

Yamakage M, Kimura A, Chen X, Tsujiguchi N, Kamada Y, Namiki A. Production of compound A under low-flow anesthesia is affected by type of anesthetic machine. Can J Anaesth. 2001;48:435–438.