Anemia of Chronic Diseases

Published on 04/03/2015 by admin

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Last modified 04/03/2015

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Chapter 9 Anemia of Chronic Diseases

Jane A. Little, Edward J. Benz, Jr., Lawrence B. Gardner

Table 9-1 Suspected Causes of Anemia of Chronic Disease

Shortened erythrocyte survival

Block in reuse of iron by erythrocyte

Direct inhibition of erythropoiesis

Relative deficiency of erythropoietin

Diagnosis of Anemia of Chronic Diseases

The diagnosis of ACD is primarily one of exclusion and often is difficult. Various laboratory tests have been suggested, but few have proven value in the general population because ACD occurs in too large a variety of acute and chronic illnesses. The best way to diagnose ACD, at least provisionally, is to document an anemia of underproduction (i.e., low reticulocyte index) with low serum iron and low transferrin levels and an elevated serum ferritin level in the setting of a systemic, usually inflammatory, illness. A thorough search may be necessary to document the precise underlying illness.

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