Whipple Disease

Published on 19/07/2015 by admin

Filed under Radiology

Last modified 19/07/2015

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 Distal duodenum and jejunum are most often involved, with distal small bowel/ileum involved in severe cases

image Thickened, irregular folds with sand-like micronodules
image Small bowel lumen may be normal or mildly dilated
• CT

image Low-density enlarged mesenteric and retroperitoneal lymph nodes that may have near fat-density
image Thickened proximal small bowel folds ± submucosal edema due to hypoalbuminemia
• MR

image Lymph nodes may show ↑ T1 signal due to fat

TOP DIFFERENTIAL DIAGNOSES

• Celiac disease
• Intestinal opportunistic infections
• Dysgammaglobulinemia
• Intestinal metastases and lymphoma

PATHOLOGY

• Caused by  Tropheryma whipplei

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