Distal duodenum and jejunum are most often involved, with distal small bowel/ileum involved in severe cases
Thickened, irregular folds with sand-like micronodules
Small bowel lumen may be normal or mildly dilated
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CT
Low-density enlarged mesenteric and retroperitoneal lymph nodes that may have near fat-density
Thickened proximal small bowel folds ± submucosal edema due to hypoalbuminemia
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MR
Lymph nodes may show ↑ T1 signal due to fat
TOP DIFFERENTIAL DIAGNOSES
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Intestinal opportunistic infections
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Intestinal metastases and lymphoma
PATHOLOGY
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Caused by
Tropheryma whipplei
Related
Diagnostic Imaging_ Gastrointes - Michael P Federle
