Vesiculobullous reaction pattern

Published on 08/03/2015 by admin

Filed under Pathology

Last modified 22/04/2025

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6 Vesiculobullous Reaction Pattern

Intraepidermal blisters 98

Spongiotic blistering disease 98

Palmoplantar pustulosis 98

Amicrobial pustulosis associated with autoimmune disease 98

Viral blistering diseases 99

Friction blister 99

Suprabasilar blister 100

Pemphigus vulgaris 100

Pemphigus vegetans 101

Paraneoplastic pemphigus 102

Hailey-Hailey disease 103

Darier’s disease 103

Grover’s disease 104

Acantholytic solar keratosis 104

Subepidermal blisters with eosinophils 120

Bullous pemphigoid 120

Bullous pemphigoid, urticarial stage 121

Pemphigoid gestationis 122

Bullous arthropod bites 123

Bullous drug reactions 123

Epidermolysis bullosa 123

Subepidermal blisters with mast cells 130

Bullous mastocytosis 130

Miscellaneous blistering diseases 131

Coma blister 131

Notes on immunofluorescence 132

Table of major bullous disorders and immunofluorescence results 132

Vesiculobullous reaction pattern

Bullous disorders along the basement membrane zone (BMZ)

Notes on immunofluorescence (IF)

• Biopsy placed in Michel’s solution (contains ammonium sulfate)

• DIF = detect tissue-bound immunoreactant, while indirect IF = detect circulating autoantibodies

• Usually use fluorescein isothiocyanate to fluoresce = absorbs at 490–495 nm (blue) and peak emission at 510–517 nm (green color)

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