Vascular Conditions

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Chapter 117

Vascular Conditions

Renovascular Hypertension

Overview: Approximately 5% to 10% of children and adolescents with severe hypertension have an underlying renal vascular lesion. In infants, up to 70% of clinically significant hypertension is due to renovascular disease. Myriad developmental and acquired causes of renovascular hypertension exist (Box 117-1). A complication related to umbilical artery catheterization is the most common cause of renovascular hypertension in neonates. In older children, renal arterial fibromuscular dysplasia is the most common cause.14

Imaging: Asymmetry of the kidneys on sonography is an important sign of possible renovascular hypertension. The affected kidney often is small and may have manifestations of scarring. Direct visualization of a stenotic renal arterial lesion is uncommon with sonography, however. Evaluation of the aorta also is an important component of the examination. With Doppler evaluation, a renal artery-to-aorta peak systolic velocity ratio of greater than 3.5 carries a strong association with renal arterial stenosis. A peak velocity in the renal artery of greater than 180 cm/s also is suggestive of renal artery stenosis. Distal to the stenotic lesion, the systolic peak of the renal arterial waveform often appears flattened (Fig. 117-1). With severe stenosis, Doppler evaluation of distal arteries shows a tardus-parvus pattern, with slow systolic acceleration and diminished peak systolic velocity. Diastolic flow in the main renal artery sometimes is elevated.5

The most useful scintigraphic technique for detection of renovascular hypertension involves the evaluation of renal function without and with the use of an angiotensin-converting enzyme inhibitor, usually captopril or enalaprilat. MAG3 is the optimal imaging agent for this study. In the presence of renovascular disease, imaging in conjunction with angiotensin-converting enzyme inhibitor therapy typically shows diminished perfusion, diminished initial uptake, and poor parenchyma clearance of the affected kidney. Comparative imaging in the absence of antihypertensive therapy shows improved function (Fig. 117-2). The sensitivity of this technique for the detection of renovascular hypertension is approximately 85% to 90%. Bilateral renal artery stenosis or markedly compromised renal function can lead to false-negative examinations.6

Transcatheter angiography is the most sensitive and specific technique for the detection and identification of small-vessel renal artery disease. Computed tomographic angiography (CTA) and magnetic resonance angiography (MRA) are important noninvasive techniques for visualization of renal vascular anatomy. Upon administration of contrast material, global and regional alterations in kidney perfusion and function also can be assessed with computed tomography (CT) and magnetic resonance imaging (MRI). In general, >50% narrowing of the renal arterial diameter is hemodynamically significant. The presence of enlarged collateral pathways is an additional indicator of significant renal artery stenosis. Transcatheter renal vein renin sampling is useful in selected cases of suspected renal hypertension (Fig. 117-3).7,8

Renal Fibromuscular Dysplasia

Middle Aortic Syndrome

Overview: Middle aortic syndrome (midaortic dysplastic syndrome) is an acquired, progressive vascular disorder that involves the midthoracic through abdominal segments of the aorta and usually is accompanied by narrowing of major visceral branches, including the renal arteries. Imaging studies show diffuse narrowing of the thoracoabdominal segment of the aorta and the major branch vessels (Figs. 117-6 and 117-7). If renal artery narrowing is severe, collateral flow to the kidneys usually occurs via ureteral, adrenal, and gonadal arteries that fill from lower intercostal vessels.16,17

Renovascular Trauma

Imaging: Globally deficient parenchymal contrast enhancement is an important CT indicator of possible disruption, thrombosis, or spasm of the main renal artery. Contrast enhancement in the periphery of an ischemic kidney (the “cortical rim sign”) is a radiographic indicator of acute renal arterial occlusion. The cortical rim sign does not develop until at least 8 hours after the onset of ischemia; in many patients, it is not present until a few days after the injury. This sign generally indicates that renal salvage is not possible because of the prolonged nature of the ischemia.

With complete traumatic disruption of the main renal artery, CT shows a large adjacent hematoma. A localized renal infarction due to traumatic occlusion of an intrarenal vessel results in a wedge-shaped or rounded area of absent enhancement, often with sharp margins. With partial main renal artery occlusion, the nephrogram intensity is diminished.

Aneurysm

Imaging: Renal artery aneurysms can be single or multiple; most are saccular. A clot or calcification occasionally is present within the aneurysm (Fig. 117-8). Aneurysms that occur in patients with polyarteritis nodosa tend to be small, multiple, and intraparenchymal. Most are detectable with sonography, CTA, or MRA. Conventional angiography sometimes is required for the detection and characterization of small lesions.20

Thrombosis, Embolism, and Infarction

Imaging: In the acute phase of renal artery thromboembolism, sonography is normal or shows nonspecific renal enlargement and cortical hyperechogenicity. Doppler evaluation sometimes reveals global, focal, or multifocal perfusion deficits. Flow within the capsule may be increased. Careful evaluation of the main renal artery sometimes demonstrates an echogenic clot, as well as abnormal arterial waveforms. If the main renal artery is patent in a patient with renal infarction, the resistive index often is elevated.

CTA and MRA of patients with renal arterial thromboembolic disease may reveal filling defects or narrowing of the renal artery. With global renal infarction, renal parenchymal enhancement and normal contrast media excretion are lacking. One or more wedge-shaped enhancement defects may occur in the presence of segmental renal infarction. In about 50% of patients with renal infarction, a thin, prominently enhancing rim is visible at the peripheral margin of an infarction (Fig. 117-9).

Diseases of the Intrarenal Arteries

Renal Vasculitis

Overview: The kidney is a relatively common site of involvement in various forms of vasculitis. The most widely used classification of vasculitis is based on the size of the predominantly involved vessels. Takayasu arteritis is an example of large-vessel vasculitis. Polyarteritis nodosa and Kawasaki disease predominantly involve medium-sized vessels. The presence or absence of antineutrophil cytoplasmic antibodies (ANCAs) allows subcategorization of the small-vessel vasculitides. Henoch-Schönlein purpura (HSP) is ANCA negative; ANCA-positive vasculitides that can affect the kidney include Wegener granulomatosis and microscopic polyarteritis. Small-vessel vasculitis also can occur in association with various infectious diseases, such as Rocky Mountain spotted fever, human immunodeficiency virus, hepatitis B, and tuberculosis.24

Polyarteritis Nodosa

Overview: Polyarteritis nodosa is a rare idiopathic focal segmental necrotizing vasculitis. Renal involvement occurs in slightly more than half of affected children. Clinical manifestations of kidney involvement include hematuria, proteinuria, and hypertension. Imaging studies of the kidneys may show manifestations of focal or multifocal renal ischemia. Intraparenchymal or perirenal hemorrhage can occur as the result of aneurysm rupture. Arteriography reveals small aneurysms, typically located at the bifurcations of interlobular or arcuate arteries. Small intrarenal vessels are irregular and tortuous because of vascular and perivascular inflammation (Fig. 117-10).25

Wegener Granulomatosis and Microscopic Polyarteritis

Systemic Lupus Erythematosus

Hemolytic-Uremic Syndrome

Overview: Hemolytic-uremic syndrome is the most common cause of acute renal failure in early childhood. The pathogenesis involves endothelial cell damage within glomeruli and renal arterioles. The kidney is the main target of this microangiopathy, although the intestines, lung, and brain variably are affected. In most cases of hemolytic-uremic syndrome, fever, vomiting, bloody diarrhea, and abdominal discomfort develop in an otherwise healthy infant. Affected children beyond infancy are usually around 3 years of age. The child may become critically ill, with signs and symptoms that include pallor, irritability, seizures, heart failure, hypertension, gastrointestinal bleeding, and oliguria. Acute renal failure usually lasts for 1 to 4 weeks, with subsequent slow improvement. Clinical recovery is complete in most patients, but some children have permanent neurologic or renal damage.30

Henoch-Schönlein Purpura

Sickle Cell Disease

Imaging: Intravenous urography and CT may show calyceal blunting and prominent papillae with broad, deep calyces. The collecting system often is distorted because of cortical hypertrophy (Fig. 117-11). In some patients, papillary necrosis is evident. Nephromegaly, usually bilateral, is common. Recurrent infarction and subsequent fibrosis eventually may lead to scarring and atrophy.36

Renal sonography of patients with sickle cell disease typically shows mild diffuse enlargement, hyperechogenicity, and loss of corticomedullary differentiation (Fig. 117-12). A perirenal hematoma can occur as a complication of renal infarction. Doppler sonography serves to detect renovascular disease. MRI shows decreased cortical signal relative to the medulla on T1-weighted and T2-weighted images as a result of iron deposition in the renal cortex.37,38

Renal Vein Thrombosis

Imaging: The typical sonographic features of RVT are abnormal parenchymal echogenicity and loss of corticomedullary differentiation; in some cases, interlobular echogenic streaks are present (Fig. 117-13). Interstitial hemorrhage occasionally leads to parenchymal hyperechogenicity. Elevation of the arterial resistive index occurs as a result of venous outflow obstruction (Fig. 117-14). Narrowing of the systolic peak also is common. Careful sonographic evaluation of the renal veins sometimes reveals an echogenic clot; however, the absence of a clot within the major renal veins does not exclude the diagnosis of small vessel renal vein thrombosis. With severe involvement, Doppler evaluation may show an absence of flow within the main renal vein. In other patients, renal vein flow is monophasic.4042

Treatment and Follow-up: Therapy of RVT is supportive and directed toward treatment of the underlying cause. Renal scintigraphy during the acute phase provides prognostic information; mild compromise of uptake and excretion indicates a good prognosis (Fig. 117-15). Within a few weeks of onset of RVT, the affected kidney decreases in size. In some patients, progression to global atrophy occurs. Follow-up imaging occasionally demonstrates a reticular pattern of calcification within the intrarenal veins; this finding is essentially pathognomonic of previous renal vein thrombosis.

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