Figure 16-1 A historical perspective on the role of the microenvironment in cancer A timeline detailing landmark discoveries that showed the dominance of microenvironment over genotype. If space had permitted, a number of other important experiments could have been included, such as Emerman and Pitelka’s demonstration that normal mammary epithelial cells on floating collagen gels recapitulate their in vivo phenotype, 14 Folkman’s demonstration that cell shape regulates DNA synthesis, 15 and experiments demonstrating that reconstituted 3D BM gels act as a “blotter” to distinguish the normal from the malignant phenotype. 16,17
The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis
Published on 09/04/2015 by admin
Filed under Hematology, Oncology and Palliative Medicine
Last modified 22/04/2025
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