Surgery for Juvenile Idiopathic (Rheumatoid) Arthritis

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Chapter 41 Surgery for Juvenile Idiopathic (Rheumatoid) Arthritis

Background/aetiology

In 1993 a taskforce was set up by the International League of Associations for Rheumatology (ILAR) to reclassify inflammatory joint disease of childhood and adolescents. The ILAR classification1 was proposed and, although this is now widely used, it is not universally accepted by rheumatologists. The requirement for diagnosis of this condition is persistent arthritis for 6 weeks or more, affecting individuals under the age of 16 years, with the classification being based on clinical and serological factors as well as on the onset and course of the disease.

The ILAR classification avoided using terms such as juvenile chronic arthritis,2 used by the European League Against Rheumatism (EULAR), and juvenile rheumatoid arthritis,2,3 used both by EULAR and by the American College of Rheumatology (ACR). The ILAR introduced the term juvenile idiopathic arthritis (JIA) to encompass the heterogeneous forms of arthritis that begin before the age of 16 years. At the same time ILAR identified seven different categories:

JIA is therefore not a single disease but a group of heterogeneous conditions.5 It is firstly an autoimmune disease with T-cell abnormalities and chronic, probably cell mediated, synovitis. Multiple autoantibodies, immune complexes and complement activation may all play a role as humoral agents. Secondly there is a genetic element with various forms of JIA displaying non-mendelian inheritance with interactions between multiple genes. With this genetic predisposition it has been postulated that there are a number of aetiological triggering events including infection, trauma, hormonal abnormalities, psychological stress and an abnormal immune response.

Presentation, investigation and treatment options

The incidence of JIA varies from 2 to 20 per 100 000 population, while the prevalence has been quoted from 16 to 150 per 100 000.5 JIA is often self-limiting with about 60% of patients reaching adulthood with no active ongoing synovitis or functional limitation.6

Investigations

The diagnosis of JIA is essentially clinical, although a variety of laboratory tests can be used to provide evidence of inflammation or disease activity, and to support the diagnosis. In addition they can also be useful as a research tool to understand the pathogenesis of the condition.5 Haematological tests include the haemoglobin level (which can sometimes be significantly lowered), leucocyte count (that can be very high) and platelet count (which may be high in systemic or polyarticular disease). The erythrocyte sedimentation rate and, more reliably, C-reactive protein can be used to monitor inflammatory response. Serum immunoglobulins are a marker of disease activity, with IgA and IgM levels also correlating with the type of onset and sex.5 Rheumatoid factor is more commonly present in the older age onset with polyarticular disease and is unusual in disease onset before 7 years. The detection of rheumatoid factor, however, rises with age and duration of the disease. Antinuclear antibodies are more useful in the diagnosis of JIA than rheumatoid factor.

Summary Box 41.1

Investigation Finding
Haemoglobin May be significantly reduced in systemic onset
Leucocyte count May be very raised in systemic onset
Platelet count May be high in systemic and polyarticular disease
Rheumatoid factor More commonly raised in older age onset with polyarticular disease

Radiological examination

X-ray changes of the elbow in JIA are similar to those described by Larsen et al in adult rheumatoid disease9 (Fig. 41.1), but in addition bony ankylosis may occur as a result of the inflammatory disease being active during skeletal growth. This complication has resulted in the original five-type Larsen classification being modified to include a sixth type (Fig. 41.2).

Surgical techniques

Outcome including literature review

Synovectomy

This procedure can be undertaken in isolation or in combination with radial head excision. Wilson et al10 noted that like other bones, for example the greater trochanter of the femur, the radial head may be overgrown as a result of JIA (Fig. 41.3). Similar results to those obtained by synovectomy in adult rheumatoid patients were originally reported in JIA.1012 However, in 2003 slightly inferior results were noted by Maenpaa et al in juvenile rheumatoid patients at an average follow-up of 5 years.13 They performed 24 elbow synovectomies in patients with JIA with 96% having elbow disease classified as Larsen 0–2. Complete pain relief occurred in 44%, although there was no gain in functional ability, and no overall improvement in range of movement, including forearm prono-supination. This compares to the outcome of this procedure in adult rheumatoid patients, in whom postoperative pain has been reported to reduce to 70–84% at 6–12 months but reducing to 45–54% at 5–6 years.1416 The operation has a greater chance of long-term success when preoperative forearm rotation is reduced to below 50% of normal and when flexion and extension are not severely limited. In this subgroup, gains of 50° in forearm rotation and 11° in flexion arc have been reported16 in contrast to that reported for JIA.13

Excision/interposition arthroplasty

Although excision arthroplasty was originally described by Ollier17 in 1882 for ankylosis of the elbow secondary to tuberculosis, it was Schuller in 1893 who recommended the operation for the treatment of the rheumatoid elbow.18 Various materials were inserted to interpose between the resected humerus and ulna to prevent reankylosis and in 1960 Gschwend and Spirig advocated the use of dermis as the interposition material.19 This then became the primary method of treating the destroyed rheumatoid elbow until the advent of modern total elbow arthroplasties. Indeed even after this time some authors continued to advise that interposition arthroplasty is the better first choice operation especially in JIA, with prosthetic replacement reserved as a salvage procedure.20

The use of interposition arthroplasty has been reported in mixed populations of adult rheumatoid patients and children with JIA. Kimura and Vainio published their results of 208 interposition arthroplasties in patients with adult and juvenile rheumatoid patients but made no distinction between the two groups.21 The average age of the patients was only 39 years with a range from 14 to 73 years. They performed 53 Ollier-type excision arthroplasties, which involved complete excision of the distal end of the humerus, olecranon and radial head, and 155 Hass-type excisions,22 in which the distal humerus was fashioned and a more conservative partial resection of the olecranon performed. In 152 cases the distal humerus was covered with a full thickness skin graft. Pain relief was good with complete relief in 81% and 67%, respectively, while a virtual 100° mean arc of flexion was obtained. The main reported complication was instability causing ulnar nerve paraesthesia and significant bone resorption in the region of the olecranon fossa. Unfortunately the follow-up period was not recorded and therefore the speed at which this bone resorption occurs is unknown. A surgical modification involving bone grafting the olecranon fossa was suggested when incidence of forking of the humerus was seen in 20% of cases followed for at least 1 year.

Further reports of interposition arthroplasty in which small numbers of patients with JIA are included have shown good functional ranges of movement.23,24 Only one paper specifically details the results in JIA patients.24 This reported four out of 12 interposition arthroplasties in patients aged 11–15 years at the time of surgery. All achieved an improvement in range of movement, which varied between a 60° and 130° flexion arc, at a long-term follow-up of between 25 and 32 years. This study, however, merely reports the flexion arc outcome and makes no mention of forearm rotation, pain, or the presence or absence of bony erosions or disease progression. Indeed it is the bone loss and instability complications of interposition arthroplasty together with the improved results obtained by elbow arthroplasty that has made the latter the first choice in the surgical treatment of the majority of patients with rheumatoid elbow disease.25 Interposition arthroplasty may, however, still be a useful option in some young patients with ankylosing disease.26

Arthroplasty

Hip and knee arthroplasties are well reported in JIA, but there is little in the literature on shoulder and elbow replacements. Only two series of shoulder replacements have been reported27,28 with a similarly small number of publications that specifically document the outcome of total elbow arthroplasty in JIA.29,30 Other series report a range of pathologies including some patients with JIA but extracting the JIA results from these is difficult or impossible since the number of such patients is usually small.

In 1972 Dee was the first to recognize, in the context of arthroplasty, that the bony architecture in burnt-out Still’s disease was grossly abnormal and advised that implant stems may need to be shortened to facilitate insertion. Unfortunately in his original series of 12 replacements using his hinged prosthesis he did not specify either the results or indeed the number of juveniles in the group.31

In 1990 Dennis et al reported modest gains in movement using the capitellocondylar prosthesis in 21 adult and juvenile rheumatoid patients.29 Less improvement was noted in the juvenile group.29 Ewald et al also reported the results of the capitellocondylar arthroplasty in patients with rheumatoid arthritis.32 Out of 202 arthroplasties in 179 individuals, 13 were in patients with JIA, representing 8% of the patients treated. Unfortunately again no distinction was made between the results for the adult and juvenile groups. In 1994 Kraay et al reported their experience of using the Osteonics prosthesis including 86 cases of inflammatory arthritis (rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus and psoriatic arthropathy) but once more no detail of either numbers or results is given for the patients with JRA.33

Connor and Morrey30 reported the results of 24 elbow replacements in 19 patients with juvenile rheumatoid arthritis at a mean follow-up of 7.4 years. Eighteen linked (Coonrad–Morrey) and six unlinked (capitellocondylar) implants were used over a 12-year period (1982–94). The authors recognized the difficulty of performing total elbow replacements in these patients because of the contracture of the soft tissues and the extremely small bones and intramedullary cavities. Unlike in my practice, however, they did not find it necessary to use custom-made prostheses. Nine of their patients had undergone previous surgery to the elbow, seven having synovectomy and radial head excision and two having interposition arthroplasty. They noted little or no pain at follow-up but achieved only a moderate increase in movement, with the flexion arc increasing from 63° to 90° postoperatively. Despite this, the average Mayo elbow performance score (MEPS)34 rose from 31 points (range 5 to 55 points) preoperatively to 90 points (range 55–100 points) postoperatively. These results are consistent with the same author’s experience of using the Coonrad–Morrey total elbow replacement in adult rheumatoid patients when at a minimum 10-year follow-up an identical postoperative MEPS of 90 was reported.35 The main difference in the use of total elbow arthroplasty for the treatment of adult versus juvenile rheumatoid patients is the quoted complication rate of 14% in the former and 50% in the latter.

The only other reference specific to elbow arthroplasty in JIA is an abstract from the closed meeting of the American Shoulder and Elbow Surgeons in November 1998 published in 1999.36 This abstract reports the largest series of total elbow arthroplasties for JIA. Forty-five patients were treated using three types of linked implants. The average age of the patients at the time of surgery was 28.5 years (range 14–53). Nineteen customized implants were used because of the small size of the humerus and ulna. An overall improvement in the flexion arc from 38° to 101° was achieved and this is particularly noteworthy since 16 of the elbows were ankylosed preoperatively. In the ankylosed group the flexion arc improved from 0° to 83° whereas in the non-ankylosed group it increased from 59° to 110°. The Hospital for Special Surgery Score improved from a mean preoperative value of 32 (range 6–52) to a mean postoperative score of 91 (range 0–100) at an average follow-up of 10.5 years (range 2–23). The reported complication rate was 29%, the most common complications being fractures to either the epicondyle or olecranon. It is unclear, however, whether these occurred intraoperatively or postoperatively. Only two arthroplasties loosened despite the use of nine uncemented implants. Although published as an abstract, the definitive paper has not subsequently appeared in the literature and therefore no further details on this group of patients are available.

The only other literature on total elbow arthroplasties in this group of patients is either confined to case reports,37 or includes small numbers of JIA patients with adult rheumatoid cases and makes no distinction regarding the outcome in the two groups.38 There are two reports published in this century dealing with total elbow replacement for ankylosed or stiff elbows, and, although these contain some patients with JIA, the results of this subgroup are not separated from the whole group.39,40

Preoperative assessment

The size of the skeleton in JIA is often diminished especially in those cases where the onset of disease occurs at an early age. In this personal series the mean age at diagnosis was only 7 years and therefore growth disturbance had occurred in a significant number by the time joint replacement surgery was performed.

For this reason it is essential that whenever a total elbow arthroplasty is being undertaken in a patient with JIA, appropriate preoperative radiographs are performed in order to allow templating of the prosthesis (Fig. 41.4). This will enable identification of the correct size of the implant and permit customization if extra-small prostheses are required. Of the six Coonrad–Morrey prostheses inserted in this series, all of the humeral and four of the ulnar components were small, with the remaining two ulnar implants being extra-small because of the small size of the intramedullary canal. Of the 13 titanium Kudo implants inserted nine were small components, two extra-small humeral and ulnar components were customized preoperatively because of the small intramedullary canal, and two ulnar components were customized intraoperatively.

The Kudo prosthesis was originally made for the Japanese population and as such the small components are very small. It was for this reason that this prosthesis was chosen in these patients. It was my view that it gave the best option for dealing with the significant challenges presented by the small intramedullary canal size of patients with JIA.30,41

In addition to appropriate preoperative surgical preparation it is essential to have an experienced anaesthetist with skills in endoscopic intubation. Patients with JIA often have temporomandibular joint involvement and in childhood that can result in micrognathia and retrognathia, with an anterior open underbite, which significantly limits the ability to open the jaw.5 This combined with cervical spine disease and a reduction in neck extension can make intubation very difficult.

Operative technique

My preference for arthroplasty is to use a posterior approach. A tongue of triceps aponeurosis is raised from the underlying triceps muscle separating it from the triceps raphe. Extending this on the lateral side allows the lateral head of triceps and anconeus to be mobilized and retracted as a single entity. The radial head, if present, is resected and the ulnar nerve is decompressed within the cubital tunnel and between the two heads of flexor carpi ulnaris. During surgery the nerve is carefully retracted with its surrounding soft tissues and vessels so that it is not devascularized. At the end of the procedure the nerve is restored to its original position and is not transposed. On the medial side the triceps raphe is incised 2 cm proximal to its insertion, and the medial and deep heads of triceps are reflected medially exposing the distal humerus. The medial collateral ligament is released in its entirety to allow dislocation of the elbow. Releases are also performed on the lateral side to balance the elbow. This is important when using an unlinked implant since these devices rely on a balanced soft tissue envelope for the components to track correctly and therefore maintain joint stability.

The preparation of the intramedullary canals of the humerus and ulna is difficult due to their reduced size and in some cases due to the fact that the canal is obliterated by cortical bone. Once the canal has been identified by careful burring a useful technique is to use a malleable plastic sucker (e.g. Yanker) to expand and further identify the canal, thus preventing the cortex from being breached. Following this a small flexible metal reamer (4 or 5 mm) is used to enlarge the canal.

Rehabilitation

Postoperatively an extension splint is used at night for 4 weeks in an attempt to maintain extension. The patient is encouraged to perform active flexion movements during the day as pain allows. No specific physiotherapy regimen is used other than the normal practice in patients with inflammatory joint disease of maintaining joint mobility in surrounding joints, while encouraging active movement of the replaced joint.

Complications of treatment

Six elbow replacements had intra- and postoperative complications. These included two fractures of the olecranon (one intraoperative and one postoperative), both of which occurred in patients with severe bone loss secondary to previous interposition arthroplasties. The patients had pitch fork deformities of the distal humerus and significant narrowing and thinning of the olecranon.

Two patients had transient ulnar neuritis that resolved spontaneously, with another patient having persistent symptoms that were alleviated after the nerve was explored and released 9 months following the joint replacement. One patient had a triceps rupture 1 year postoperatively which required surgical repair. Six years later, the same elbow was revised for a failed Coonrad–Morrey implant (Figs 41.10, 41.11).

Revision surgery

A total of five elbows arthroplasties in three patients have been revised, three Kudo unlinked and two linked Coonrad–Morrey prostheses.

Two Kudo replacements have been revised for ulnar component tilting with instability and pain, and one for ulnar component loosening 8 years post-arthroplasty. The latter developed rapidly after the patient had undergone a revision hip replacement requiring an extended period of mobilization on elbow crutches. This patient has multiple joint replacements including bilateral elbow replacements. A customized long curved stem ulnar component was used, the cemented humeral component being solid. Postoperatively the patient made an excellent recovery gaining a MEPS of 85 within 6 months of revision.

The cause of the two tilted ulnar components appears to be due in part to the small size of the ulnar medullary canal, and in part to the straight stem of the Kudo ulnar component that cannot navigate the small canal without tilting. A more anatomical ulnar stem is recommended in subsequent cases. Alternatively shortening the stem length of the ulnar component will also prevent this complication in these small bones. Two elbows in the same patient have been revised for ulnar component loosening of Coonrad–Morrey arthroplasties. Both revisions were complicated by infection and requiring salvage to an excision arthroplasty. At this time no further surgery is complicated. This patient, who had previously undergone bilateral interposition arthroplasties complicated by bone erosion and pain, also had a transient ulnar nerve palsy after one primary and a triceps rupture and proximal humeral fracture following a horse riding accident to the contralateral side. Indeed out of a total of 11 complications and revisions this one patient accounts for four of these episodes.

Complications and reoperation

There were 11 complications affecting nine out of the 19 elbows (47%). This compares well to the 50% reported by Gill and Morrey.35 All but one of the six complications and four of the five revisions occurred in patients who had undergone previous surgery to the elbow. Four out of the five revisions were in patients whose first operation had been an interposition arthroplasty.

Both previous interposition arthroplasty42 and synovectomy with radial head excision43 have been shown to be associated with an increased complication rate following elbow arthroplasty. The complication rates quoted for elbow arthroplasty in adult rheumatoid patients varies considerably. Gschwend44 reported an overall rate of 43% on reviewing the literature from 1986 to 1992. Little et al45 in a review of the literature to 2003 noted complication rates of between 14% and 80% with a median of 33%. A complication rate of between 47% and 50% is, therefore, not excessive given this highly complex group of patients, many of whom had already undergone previous surgery.

Conclusions/personal view

Patients with JIA represent a group of severely handicapped individuals who, because of the age of onset of their disease, frequently require multiple joint procedures to both their lower and upper limbs. At the elbow synovectomy, interposition arthroplasty and elbow replacement are all surgical options that can be used to reduce pain and improve range of movement and function. The development of the newer generation disease-modifying drugs, however, together with better overall medical management should reduce severe joint destruction, limit soft tissue contractures, and prevent the abnormalities of growth that have historically characterized the juvenile rheumatoid patient. It remains to be seen whether this more modern management will affect the presentation of such cases to the orthopaedic surgeon. At the present time I assess a patient for radial head excision and synovectomy along the lines suggested by Gendi et al.16 I consider the important part of the operation to be the restoration of forearm rotation which is achieved by removal of the frequently overgrown and impinging radial head.

Interposition arthroplasty has been used for many years in my hospital to treat both adult rheumatoid and juvenile idiopathic arthritis. While in some cases significant and sometimes rapid bony erosion of the humerus and ulna have been observed, in others there has been a gradual erosion of the joint over years similar to the natural history of the disease. It is my view that this operation should nowadays be confined to the ankylosed joint in the skeletally immature. With the improvements in medical care this situation should now be a rarity.

When assessing a patient with JIA for an elbow replacement it is important to fully appreciate the complex bone and soft tissue anatomy and to be aware that customization of implants may be required and should always be considered. Even when using the smallest implants the components will often fill the intramedullary canal resulting in only a very thin cement mantle. This may be one of the causes of early loosening. Component malalignment may also occur because of the difficulty of accurately positioning the implants in the bone due to the small size of the intramedullary canal. Great care must therefore be taken when the components are inserted to align the articular axis of the prosthesis with the anatomical axis of the elbow. If this is not achieved unlinked implants will have a tendency to tilt or dislocate. In a linked implant, this rotational malalignment may be concealed when locking the two components, but maltracking will result in an abnormal strain on the linkage, resulting in bushing wear and loosening. Correct soft tissue balancing is also required to achieve correct alignment and stability.

Neither the results reported in the literature nor my own series can give any valid comparison between linked and unlinked implants in the treatment of JIA. Both types of implant result in pain relief and improvement in movement and function, although the complication rate should not be underestimated, especially if previous surgery has been performed. Future revision surgery on other joints especially the hip and knee may mean that significant stress with inevitable weight-bearing through the elbow, may compromise the function of the arthroplasty.

JIA is a progressive disease and patients become more disabled with time, some with failing lower limb joints. I have certainly seen patients who were walkers at the time of their elbow replacement end up transferring to wheelchairs using their upper limbs to aid weight-bearing. This will compromise the function of the total elbow replacement and increase the risks of loosening. If this occurs and significant bone stock is lost, revision arthroplasty surgery may be impossible and excision arthroplasty may be required to salvage the situation.

References

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