Splenomegaly

Published on 22/03/2015 by admin

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Last modified 22/03/2015

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Chapter 480 Splenomegaly

Differential Diagnosis

Specific causes of splenomegaly are listed in Table 480-1. A thorough history with a focus on systemic complaints (fever, night sweats, malaise, weight loss) in combination with a complete blood count and careful review of the peripheral smear can help guide diagnosis. Unique problems are discussed next.

Table 480-1 DIFFERENTIAL DIAGNOSIS OF SPLENOMEGALY BY PATHOPHYSIOLOGY

ANATOMIC LESIONS

HYPERPLASIA CAUSED BY HEMATOLOGIC DISORDERS

Acute and Chronic Hemolysis*

Chronic Iron Deficiency

Extramedullary Hematopoiesis

INFECTIONS

Bacterial

Viral*

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