Probably result and not cause of reflux
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Peptic stricture (1-4 cm length): Concentric, smooth, tapered narrowing of distal esophagus
TOP DIFFERENTIAL DIAGNOSES
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Drug-induced esophagitis
PATHOLOGY
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Lower esophageal sphincter (LES): Decreased tone leads to increased reflux
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Hydrochloric acid (HCl) and pepsin: Synergistic effect
CLINICAL ISSUES
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15-20% of Americans have heartburn due to reflux
Prevalence of GERD has increased sharply with obesity epidemic
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Symptoms: Heartburn, regurgitation, angina-like pain
Dysphagia, odynophagia
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Confirmatory testing: Manometric/ambulatory pH-monitoring techniques
Endoscopy, biopsy, and histological studies
TERMINOLOGY
Definitions
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Inflammation of esophageal mucosa due to gastroesophageal (GE) reflux
IMAGING
General Features
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Best diagnostic clue
Irregular ulcerated mucosa of distal esophagus on barium esophagram
Most common sign
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Finely nodular or granular appearance with poorly defined radiolucencies that fade peripherally due to edema and inflammation of mucosa
•
Location
Distal 1/3 or 1/2 of esophagus
•
Other general features
Complication of gastroesophageal reflux disease (GERD)
Based on onset, classified clinically and radiologically
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Acute or chronic reflux esophagitis
Severity of reflux esophagitis
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Depends on intrinsic resistance of mucosa
Radiographic Findings
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Double-contrast esophagography
Acute reflux esophagitis
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Decreased primary wave of peristalsis with increased tertiary contractions
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Mucosal nodularity
Fine nodular, granular, or discrete plaque-like defects (pseudomembranes)
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Foreshortening of esophagus
Due to spasm of longitudinal muscles
Not necessarily fibrotic stricture
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Ulcers
Single or multiple tiny collections of barium with surrounding mounds of edematous mucosa
Radiating and puckering of folds
Usually at or near GE junction
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Thickened vertical or transverse folds (> 3 mm)
Chronic or advanced reflux esophagitis
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Decreased distal esophageal distensibility with irregular, serrated contour (due to ulceration/edema/spasm)
Due to ulceration, edema, or spasm
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Sacculations and pseudodiverticula may be seen
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Peptic stricture (1-4 cm length/0.2-2 cm width)
Concentric smooth-tapered narrowing of distal esophagus with proximal (upstream) dilatation
Some may resemble Schatzki rings, but are generally thicker
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“Stepladder” appearance
Transverse folds due to vertical scarring
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Hiatal hernia
Seen in > 95% of patients with peptic stricture
Probably result and not cause of reflux
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Inflammatory pseudopolyp
Single enlarged fold arising at GE junction
No malignant potential but may need endoscopy with biopsy to rule out cancer
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Diagnostic Imaging_ Gastrointes - Michael P Federle