Reflux Esophagitis

Published on 19/07/2015 by admin

Filed under Radiology

Last modified 19/07/2015

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 Probably result and not cause of reflux

• Peptic stricture (1-4 cm length): Concentric, smooth, tapered narrowing of distal esophagus

TOP DIFFERENTIAL DIAGNOSES

• Scleroderma
• Drug-induced esophagitis
• Viral esophagitis
• Candida esophagitis
• Caustic esophagitis

PATHOLOGY

• Lower esophageal sphincter (LES): Decreased tone leads to increased reflux
• Hydrochloric acid (HCl) and pepsin: Synergistic effect

CLINICAL ISSUES

• 15-20% of Americans have heartburn due to reflux

image Prevalence of GERD has increased sharply with obesity epidemic
• Symptoms: Heartburn, regurgitation, angina-like pain

image Dysphagia, odynophagia
• Confirmatory testing: Manometric/ambulatory pH-monitoring techniques

image Endoscopy, biopsy, and histological studies
image
(Left) Graphic shows a small type 1 (sliding) hiatal hernia, associated with foreshortening of the esophagus, ulceration of the mucosa, and tapered stricture of the distal esophagus.

image
(Right) Film from an air-contrast esophagram demonstrates a small hiatal hernia image, foreshortening of the esophagus, and a mild stricture at the gastroesophageal (GE) junction. There are several subtle esophageal ulcers image at the level of the stricture.
image
(Left) Spot film from a barium esophagram shows a small hiatal hernia. Note the gastric folds image extending above the diaphragm. The esophagus appears shortened, presumably due to spasm of the longitudinal muscles within its wall. A stricture is present at the GE junction, and persistent collections of barium indicate mucosal ulceration image.

image
(Right) An esophagram in the same patient shows that a 13 mm barium-impregnated pill image cannot pass through the peptic stricture.

TERMINOLOGY

Definitions

• Inflammation of esophageal mucosa due to gastroesophageal (GE) reflux

IMAGING

General Features

• Best diagnostic clue

image Irregular ulcerated mucosa of distal esophagus on barium esophagram
image Most common sign

– Finely nodular or granular appearance with poorly defined radiolucencies that fade peripherally due to edema and inflammation of mucosa
• Location

image Distal 1/3 or 1/2 of esophagus
• Other general features

image Complication of gastroesophageal reflux disease (GERD)
image Based on onset, classified clinically and radiologically

– Acute or chronic reflux esophagitis
image Severity of reflux esophagitis

– Depends on intrinsic resistance of mucosa

Radiographic Findings

• Double-contrast esophagography

image Acute reflux esophagitis

– Decreased primary wave of peristalsis with increased tertiary contractions
– Mucosal nodularity

image Fine nodular, granular, or discrete plaque-like defects (pseudomembranes)
– Foreshortening of esophagus

image Due to spasm of longitudinal muscles
image Not necessarily fibrotic stricture
– Ulcers

image Single or multiple tiny collections of barium with surrounding mounds of  edematous mucosa
image Radiating and puckering of folds
image Usually at or near GE junction
– Thickened vertical or transverse folds (> 3 mm)
image Chronic or advanced reflux esophagitis

– Decreased distal esophageal distensibility with irregular, serrated contour (due to ulceration/edema/spasm)

image Due to ulceration, edema, or spasm
– Sacculations and pseudodiverticula may be seen
– Peptic stricture (1-4 cm length/0.2-2 cm width)

image Concentric smooth-tapered narrowing of distal esophagus with proximal (upstream) dilatation
image Some may resemble Schatzki rings, but are generally thicker
– “Stepladder” appearance

image Transverse folds due to vertical scarring
– Hiatal hernia

image Seen in > 95% of  patients with peptic stricture
image Probably result and not cause of reflux
– Inflammatory pseudopolyp

image Single enlarged fold arising at GE junction
image No malignant potential but may need endoscopy with biopsy to rule out cancer

CT Findings

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