Oncology

Published on 21/03/2015 by admin

Filed under Pediatrics

Last modified 21/03/2015

Print this page

rate 1 star rate 2 star rate 3 star rate 4 star rate 5 star
Your rating: none, Average: 0 (0 votes)

This article have been viewed 919 times

Chapter 14 Oncology

Long Case

Oncology

The oncology long case provides an opportunity for a general paediatrician to display competence in assessing and managing a child with cancer, and his or her family, both within multiple contexts: the domestic situation, schooling requirements, wider social relationships and within the medical framework. The medical needs reflect the multi-layered levels of care required for the patient and delivered by the general practitioner, the general paediatrician, the paediatric oncologist and other consultants whose help may be required from time to time.

The general paediatrician (the candidate) should be able to demonstrate that he or she can competently handle the medical aspects of a child with cancer as well as the complex professional interrelationships that are involved in coordinating care. The candidate should also be familiar with any recent advances that could affect the management of the patient, which requires a close relationship with the treating oncologist.

The last few years have seen many advances in most areas of paediatric oncology, including a more detailed understanding of the genetic basis of cancer, the development of disease specific investigations and an expansion of disease classifications. For example, acute myeloid leukaemia (AML) is now regarded as a group of related but biologically distinct diseases. This has led to specific treatments being developed for specific subtypes of AML. Advances in paediatric oncology have led to the recognition that prognosis and relapse risk for patients can be better defined by use of multiple molecular biology techniques, such as the use of very sensitive methods to detect cancer-specific genetic changes, which are used to detect minimal residual disease (MRD) burden after therapy. In addition, advances have led to a better understanding of the interacting abnormal genetic and mechanisms that are responsible at a molecular level for the pathogenesis of neoplasms.

Haematopoietic stem cell transplantation (HSCT) now has an expanded set of indications for malignant diseases, including various subgroups of patients with acute lymphoblastic leukaemia (ALL), AML and myelodysplasia.

Of great importance is the role of medical practitioners to provide long-term sensitive surveillance and follow-up. A web-based comprehensive set of guidelines for management of such survivors, the Children’s Oncology Group (COG) Long-term Follow-up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers, can be found at www.survivorshipguidelines.org. Both these initiatives have expanded the literature significantly and are very useful to many candidates.

In Australia and New Zealand, all major paediatric centres are members of the US-based Children’s Oncology Group (COG), a consortium of childhood cancer centres that promotes clinical and laboratory research trials in paediatric oncology.

The general principles of care are similar for patients with haematological malignancies, solid tumours or brain tumours.

An approach to any oncology long case could potentially fit into the following scheme.

History: an overview

At the outset of the interview, it is important to identify clearly the primary and secondary diagnoses, as well as important historical landmarks such as the date of diagnosis, the date of completion of therapy, the history of relapse, or major secondary events such as significant sequelae of therapy (e.g. endocrinopathies or second tumours). Spend your time wisely and carefully in the interview. Limit yourself to about 1–3 minutes to synthesise an overview of the child’s condition and focus on gathering data relevant to the presentation. Parents of oncology patients have frequently had sustained and prolonged medical contact, and could fill hours recounting ‘what the doctor said’. This approach is very time-consuming and often unhelpful.

Before diagnosis

1. Initial symptoms (with particular reference to the usual non-specific nature of oncology symptoms). A notable difference from adult presentation is the paucity of these symptoms. Unlike adults with cancer, it is very unusual for a child to present with weight loss, haemoptysis or haematemesis and melaena. Symptoms that may present in children include a mass, and the eight ‘Ps’: Pyrexia, Pain, Pallor, Purpura, Persistent squint, Personality change, Posterior fossa symptoms, and do not forget the Pretenders (i.e. ALL or neuroblastoma impersonating arthritis, or mediastinal lymph nodes impersonating asthma).

2. Symptom duration (may give a guide to disease ‘tempo’). For example, patients with B-cell lymphoma may present as extremely ill, with a history of illness spanning a few days, compared to a patient with a brain tumour or other solid tumour, who may have experienced symptoms for many months.

3. Parental guilt about acts of commission or omission may have contributed to their child developing cancer.

4. An enquiry about the parent’s feeling towards the diagnosis is often revealing. Most parents are initially very angry, an anger that may be self-directed and related to guilt, or directed at doctors or others who they perceive as having failed in their duty to provide an early diagnosis—although, at the time, the non-specific symptoms may not have suggested malignancy as a likely possibility.

Factors 3 and 4 (above) will impact on the family’s approach to their sick child and possibly bias the relationships that they establish subsequently with people entrusted with the care of their children, particularly as the care and follow-up of a child with cancer nowadays can be expected to span in excess of 10 years for long-term survivors (over 70% of cases) whom we expect will survive.

Post-diagnosis phase

Important aspects in the history include an appreciation of the parents’ understanding of the details and significance of the diagnosis, or even whether the family is aware of the precise diagnosis. The candidate should enquire about the level of knowledge of treatment-related details that the family has acquired in the interval from diagnosis. The examinee should determine the family’s understanding of the prognosis, which falls into two broad categories: what they have been told by their doctor, and what they believe. The level of parental awareness and understanding of the condition is important, as this affects the parents’ level of care for the child and compliance with medication requirements and appointments. It also influences whether they strive to maintain a near-normal lifestyle for the child, or withdraw him or her from social interaction in anticipation of early death, perceived needs of additional protection and suchlike. The candidate should enquire about the impact of the diagnosis on siblings, the marital relationship, the financial situation for the family and job stresses. Parents may respond inappropriately in the post-diagnosis phase, by selling their house to relocate closer to the hospital, resigning from stable employment, or moving away from familiar and supportive communities, because they believe they are acting in the best interests of the child.

Current status of the patient

The details of the therapy received in the specific treatment protocol for that patient should be sought. The details should be general. Is most medication oral, IV or IM? Is there a central line? How many visits to the hospital for treatment? Can the local doctor or local hospital give any chemotherapy? No candidate will be expected to be familiar with all protocols. Be sure to ask about the complementary therapies.

Enquire about problems such as infections (especially pulmonary), marrow suppression and complications arising from this (such as febrile neutropenic episodes, anaemia and thrombocytopenia), compliance with oral chemotherapy and pneumocystis prophylaxis with cotrimoxazole (or a similar drug), and any other side effects from therapy, including nausea, vomiting and rashes. Then concentrate on the current status, particularly the immediate (rather than late) effects of treatment and their consequences, such as: lethargy and easy fatiguability from anaemia; nausea, vomiting and anorexia, resulting in weight loss; alopecia; limitation of activities (e.g. swimming) because of the presence of central lines, or ostomies involving the gastrointestinal or genitourinary tracts.

Other

The impact on daily activity of amputation of a lower extremity for bone tumour should be explored (and secondary consequences such as kyphoscoliosis sought during physical examination). Growth and development should be explored with the families. Social issues and schooling can then be discussed in the light of the foregoing information.

Finally, details of late effects of treatment and underlying illness should be sought.

Any family history of conditions associated with a predisposition to malignancy should be noted (e.g. immunodeficiencies, neurofibromatosis type 1).

From the above, the candidate should be able to formulate a comprehensive problem list, picking up items from each of the sections, prioritising these and being ready to discuss them.

Examination

See the short-case section in this chapter on late effects of oncology treatment.

Management plan

The following is an outline of the major issues that the general paediatrician may need to address, divided into general and specific problem areas.

Discussion points

1. Relapse of primary disease.

2. Growth and development.

3. Development of second tumour.

4. Social issues.

5. Schooling.

6. Infection.

7. Immunisation.

8. Issues of ongoing chemotherapy (crisis intervention for bone marrow suppression).

9. Supportive care.

10. Haematopoietic stem cell transplantation (HSCT)

11. Therapeutic modifications: risk-adapted therapy.

12. The dying child.

Relapse of primary disease

Note that patients who relapse are unlikely to be selected for an examination. However, this does not diminish the importance of properly assessing the issues regarding relapse.

In seeking symptoms from the parents or patient, the candidate ought to enquire whether any new symptoms resemble those present before the diagnosis, and determine the level of anxiety that these new symptoms are causing. Progressive symptoms such as weight loss, unexplained anorexia, nausea, fever or the appearance of lymphadenopathy, organomegaly, excessive bruising, bleeding, gum oozing, knotty palpable masses or painful bony masses all warrant further investigation.

Growth and development

Irradiation is the single most important factor in determining long-term growth and development. The candidate should know which structures were within the treatment portal, and the total dose used. Patients treated with craniospinal irradiation will be at the combined risk of hypopituitarism and relative shortening of the vertebral column. In addition, even if the pituitary is spared, the thyroid gland may well receive sufficient radiotherapy to result in biochemical hypothyroidism that requires intervention (because if it is untreated, the risk of thyroid cancer is enhanced). Any irradiated area may demonstrate relative soft-tissue atrophy.

In the past, cranial radiotherapy was used for CNS prophylaxis in a majority of patients with ALL. Modern treatment regimens now restrict the use of cranial radiation to 10% or less of patients with ALL. Up to 50% of children treated for acute leukaemia with cranial radiotherapy can have decreased growth hormone secretion. Loss of final height can also be influenced by early (rarely precocious) onset of puberty, or (too) early institution of testosterone therapy for hypogonadism in boys. The management usually comprises growth hormone, delaying treatment with testosterone. There have been reports in the literature linking use of growth hormone with subsequent brain tumour development. However, most investigators do not believe currently that the risk is enhanced.

If there has been a bone marrow transplant, the eyes should be checked by a paediatric ophthalmologist regularly (say, 12–24 monthly) for cataracts from total body irradiation (or from steroids). Hearing may be impaired by drugs such as cisplatin or aminoglycosides, and requires regular review and audiological assessment. Ideally, a formal psychological assessment should be carried out before any cranial irradiation. After treatment, psychological assessment may be repeated on a regular basis, in conjunction with neurological examination, MRI scanning and assessment of school performance, to monitor neuropsychological outcome and provide early rehabilitative intervention if needed. The spectrum of central nervous system damage varies from decreased performance at school, to frank leukoencephalopathy, spasticity and significant intellectual impairment. Intravenous methotrexate may result in leuko-encephalopathy in children with ALL, especially after irradiation. Pubertal development may be early (rarely precocious); however, delayed puberty is more common, with high gonadotropin levels from end-organ gonadal damage.

The one issue to address in adolescent patients is future reproductive potential. In boys with tumours such as Hodgkin’s disease, sperm storage should be considered before irradiation and chemotherapy. In girls, ovarian tissue storage is now available.

Development of second tumour

The risk of developing a second malignancy may approach 15–20% at 20 years in long-term survivors of childhood cancer, and appears to be related to the original diagnosis and treatment modalities. In ALL, children who have received cranial irradiation when under 6 years of age are susceptible to brain tumours, and children who have had extensive treatment with epipodophyllotoxins (teniposide and etoposide) are at greater risk of developing acute myeloid leukaemia (AML).

Social issues

Some long-time survivors have trouble adjusting to the stress of normal life. This can be assessed by simple interview and psychometric testing. Potential problems include diminished school performance, behavioural problems, impaired attainment of social skills, ongoing anxiety regarding relapse and the financial burden of the child’s treatment on the family. These areas should be explored so that appropriate intervention can be made.

Schooling

Survivors of ALL in particular are at risk of school-related problems, including repeating grades and a need for special education. This may relate to neurological damage from CNS prophylactic therapy. Assessment of school performance allows evaluation of problems with memory, concentration and attention span: all well-recognised sequelae. The amount of schooling that a child missed during treatment should be noted. Has the trend of school absence continued after therapy was completed? If so, determine the reasons. Is it excessive concern about infections such as varicella or measles (exposures to which are not relevant more than 6 months from the end of treatment)? The school situation must always be explored at follow-up.

Infection

The child on chemotherapy

Common childhood infections occur in children receiving therapy for cancer just as in normal children, and many can be managed in the usual way, provided that the child does not appear toxic, there is an identifiable localised infection, the neutrophil count is greater than 1.0 × 109/L and regular follow-up is provided. Often chemotherapy may be continued, after consultation, through the course of mild infections, be they bacterial or viral. If a child is unwell at home, with a fever and rhinorrhoea, the parents should be advised to contact the paediatrician. If the temperature is above a previously agreed level (e.g. 38°C), then the child should be seen either in hospital.

All children on therapy who are febrile need prompt assessment, and in most cases antibiotics should be started early (without waiting for result of blood count). Blood cultures should be collected before antibiotics.

If the neutrophil count is low (below 0.5 × 109/L), the child should be admitted to hospital. The management of febrile neutropenia should include broad-spectrum parenteral antibiotic therapy (e.g. ceftriaxone, tobramycin, teicoplanin). Antibiotics ideally should be commenced within 1–2 hours of the child reaching the emergency room. It is inappropriate to wait for the results of the blood count before starting therapy with antibiotics, especially if there is any delay in processing the sample in the laboratory. In such circumstances, antibiotics should be started. If the count is normal, there is less cause for concern. Remember, however, that many patients have central venous access devices in place, which can be the cause of serious infections despite normal neutrophil numbers. Always

Related posts:

Default ThumbnailNeonatology Genetics and dysmorphology Haematology Rheumatology The respiratory system Endocrinology