Nonvenereal Treponemal Infections

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Chapter 211 Nonvenereal Treponemal Infections

Nonvenereal treponemal infections—yaws, bejel (endemic syphilis), and pinta—are caused by different subspecies of Treponema pallidum and occur in tropical and subtropical areas. The causative agents of nonvenereal treponematoses—T. pertenue, T. pallidum subspecies endemicum, and T. carateum—cannot be distinguished from T. pallidum by morphologic or serologic tests. These diseases are characterized by a relapsing clinical course and prominent skin involvement. Penicillin remains the treatment of choice for syphilis and nonvenereal treponemal infections.

211.1 Yaws (Treponema pertenue)

Stephen K. Obaro and H. Dele Davies

Yaws is the most prevalent nonveneral treponematosis. It is a contagious, chronic, relapsing infection involving the skin and bony structures caused by the spirochete T. pertenue, which is identical to T. pallidum microscopically and serologically. It occurs in tropical regions with heavy rainfall and annual temperatures ≥27°C (80°F). Almost all cases occur in children in tropical and subtropical countries. It is also referred to as “framboesia,” “pian,” “parangi,” and “bouba.” A high percentage of the population is infected in endemic areas.

T. pertenue is transmitted by direct contact from an infected lesion through a skin abrasion or laceration. Transmission is facilitated by overcrowding and poor personal hygiene in the rain forest areas of the world. The initial papular lesion, which constitutes primary yaws, also described as the “mother yaw,” occurs 2-8 wk after inoculation. This lesion typically involves the buttocks or lower extremities. The papule develops into a raised, raspberry-like papilloma and is often accompanied by regional lymphadenopathy. Healing of the mother yaw leaves a hypopigmented scar. The secondary stage lesions can erupt anywhere on the body before or after the healing of the mother yaw and may be accompanied by lymphadenopathy, anorexia, and malaise. Multiple cutaneous lesions (daughter yaws, pianomas, or framboesias) appear, spread diffusely, ulcerate, and are covered by exudates containing treponemes. Secondary lesions heal without scarring. Recurrent lesions are common within 5 yr after the primary lesion.

The lesions are often associated with bone pain resulting from underlying periostitis or osteomyelitis, especially of the fingers, nose, and tibia. The initial period of clinical activity is followed by a 5-10 yr period of latency. The appearance of tertiary stage lesions develops in approximately 10% of infected patients, with onset typically at puberty with solitary and destructive lesions. These lesions occur as painful papillomas on the hands and feet, gummatous skin ulcerations, or osteitis. Bony destruction and deformity, juxta-articular nodules, depigmentation, and painful hyperkeratosis (“dry crab yaws”) of the palms and soles are common.

The diagnosis is based on the characteristic clinical manifestations of the disease in an endemic area. Dark-field examination of cutaneous lesions for treponemes and both treponemal and nontreponemal serologic tests for syphilis, which are positive because of cross reactivity, are used to confirm the diagnosis. Differential diagnosis includes other conditions with similar cutaneous manifestations such as eczema, psoriasis, excoriated chronic scabies, tungiasis, leishmaniasis, and verucae.

Treatment of yaws consists of a single dose of benzathine penicillin G (1.2 million U IM for adults and 0.6 million U for children <10 yr) for index patients and all contacts. Patients allergic to penicillin may be treated with erythromycin, doxycycline, or tetracycline at appropriate doses for venereal syphilis (Chapter 210). Treatment cures the lesions of active yaws, renders them noninfectious, and prevents relapse. Family members, contacts, and patients with latent infection should receive the same dose as those with active disease. Eradication of yaws from endemic areas may be accomplished by treating the entire population with penicillin.

211.2 Bejel (Endemic Syphilis; Treponema pallidum subspecies endemicum)

Stephen K. Obaro and H. Dele Davies

Bejel, or endemic syphilis, affects children in remote rural communities living in poor hygienic conditions. Bejel, unlike yaws, can occur in temperate as well as dry, hot climates. Infection with T. pallidum subspecies endemicum follows penetration of the spirochete through traumatized skin or mucous membranes. In experimental infections, a primary papule forms at the inoculation site after an incubation period of 3 wk. A primary lesion is almost never visualized in human infections; however, primary ulcers have been described surrounding the nipples of nursing mothers with infected children.

The clinical manifestations of the secondary stage typically occurs 3-6 mo after inoculation and are confined to the skin and mucous membranes. They consist of highly infectious mucous patches on the oral mucosa and condyloma-like lesions on the moist areas of the body, especially the axilla and anus. These mucocutaneous lesions resolve spontaneously over a period of several months, but recurrences are common. The secondary stage is followed by a variable latency period before the onset of late or tertiary bejel. The tertiary stage can occur as early as 6 mo or as late as several years after resolution of initial symptoms. The lesions in the tertiary stage are identical to those of yaws and include gumma formation in skin, subcutaneous tissue, and bone, resulting in painful destructive ulcerations, swelling, and deformity.

The diagnosis is based on the characteristic clinical manifestations of the disease in an endemic area. Dark-field examination of cutaneous lesions for treponemes and both treponemal and nontreponemal serologic tests for syphilis, which are positive because of cross reactivity, are used to confirm the diagnosis.

Differentiation from venereal syphilis is extremely difficult in an endemic area. Bejel is distinguished by the absence of a primary chancre and lack of involvement of the central nervous system and cardiovascular system during the late stage.

Treatment of early infection consists of a single dose of benzathine penicillin G (1.2 million U IM for adults and 0.6 million U for children <10 yr). Late infection is treated with 3 injections of the same dosage at intervals of 7 days. Patients allergic to penicillin may be treated with erythromycin or tetracycline.

211.3 Pinta (Treponema carateum)

Stephen K. Obaro and H. Dele Davies

Pinta is a chronic, nonvenereally transmitted infection caused by Treponema pallidum subspecies carateum, a spirochete morphologically and serologically indistinguishable from other human treponemes. This is perhaps the mildest of the nonvenereal treponematoses. The disease is endemic in Mexico, Central America, South America, and parts of the West Indies and largely affects children <15 yr of age.

Infection follows direct inoculation of the treponeme through abraded skin. After a variable incubation period of days, the primary lesion appears at the inoculation site as a small asymptomatic erythematous papule resembling localized psoriasis or eczema. The regional lymph nodes are often enlarged. Spirochetes can be visualized on dark-field examination of skin scrapings or from biopsy of the involved lymph nodes. After a period of enlargement, the primary lesion disappears. Unlike primary yaws, the lesion does not ulcerate but can expand with central depigmented resolution. Secondary lesions follow within 6-8 mo and consist of small macules and papules on the face, scalp, and other sun-exposed portions of the body. These pigmented, highly infectious lesions are scaly and nonpruritic and can coalesce to form large plaquelike elevations resembling psoriasis. In the late or tertiary stage, atrophic and depigmented lesions develop on the hands, wrists, ankles, feet, face, and scalp. Hyperkeratosis of palms and soles is uncommon.

The diagnosis is based on the characteristic clinical manifestations of the disease in an endemic area. Dark-field examination of cutaneous lesions for treponemes and both treponemal and nontreponemal serologic tests for syphilis, which are positive because of cross reactivity, are used to confirm the diagnosis.

Treatment consists of a single dose of benzathine penicillin G (1.2 million U IM for adults and 0.6 million U for children <10 yr). Tetracycline and erythromycin are alternatives for patients allergic to penicillin. Treatment campaigns and improvement of standards of living are necessary for reduction and elimination of disease.