Neoplasms of the Larynx, Trachea, and Bronchi

Published on 27/03/2015 by admin

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Last modified 27/03/2015

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Chapter 382 Neoplasms of the Larynx, Trachea, and Bronchi

382.2 Recurrent Respiratory Papillomatosis

Papillomas are the most common respiratory tract neoplasms in children, occurring in 4.3/100,000. They are simply warts—benign tumors—caused by the human papillomavirus (HPV) (Chapter 258); the same pathology is found in condylomata acuminata (vaginal warts). HPV types 6 and 11 are most commonly associated with laryngeal disease. Fifty percent of recurrent respiratory papillomatosis (RRP) cases occur in children <5 yr, but the diagnosis may be made at any age; 67% of children with RRP are born to mothers who had condylomata during pregnancy or parturition. The risk for transmission is ∼1/500 vaginal births in mothers with active condylomata. Neonates have been reported to have RRP, suggesting intrauterine transmission of HPV.