Has been associated with cytomegalovirus infection
• Adults, usually men (mean age: 55 years)
Prolonged and progressive illness in most adults
• Complications
Gastric carcinoma may have ↑ prevalence (controversial)
Increased risk of deep venous thrombosis (DVT)
Risk of atrophic gastritis, gastric ulcer, GI bleeding
• Treatment
Medical therapy: Anticholinergic agents, antibiotics, prostaglandins, octreotide
– Monoclonal antibody (cetuximab), to EGFR
– High-protein diet
May require total gastrectomy
(Left) Film from an upper GI series shows massive fold thickening throughout the gastric fundus and body, with relative sparing of the antrum. Also noted is poor coating of the mucosa by the barium.
(Right) CECT in a 68-year-old woman with proven Ménétrier disease, shows grossly thickened folds in the gastric fundus and body, along with engorged gastric vessels . The thick, tortuous folds resemble cerebral convolutions.
(Left) Film from an upper GI series shows massive fold thickening of the gastric fundus and body, with sparing of the antrum. Note the poor coating of the gastric mucosa with barium to the surface of the stomach, reflecting the excessive mucus discharge of the gastric glands.
(Right) In the same patient, CECT shows marked thickening of the gastric mucosa and submucosa , but there is no sign of extension into the perigastric tissues. The gastric arterial and venous branches are engorged , indicating hyperemia of the stomach.
in the gastric fundus and body, along with engorged gastric vessels 
. The thick, tortuous folds resemble cerebral convolutions.
, but there is no sign of extension into the perigastric tissues. The gastric arterial and venous branches are engorged 
, indicating hyperemia of the stomach.
