Membranous Glomerulopathy

Published on 22/03/2015 by admin

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Last modified 22/03/2015

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Chapter 506 Membranous Glomerulopathy

Membranous glomerulopathy, now commonly called membranous nephropathy (MN), a common cause of nephrotic syndrome in adults, is a rare cause of nephrotic syndrome in children. MN is classified as the primary, idiopathic form, where there is isolated renal disease, or secondary MN, where nephropathy is associated with other identifiable systemic diseases or medications. In children, secondary MN is far more common than primary, idiopathic MN. The most common etiologies of secondary MN are systemic lupus erythematosus (SLE) or chronic infections. Among the latter, chronic hepatitis B infection and congenital syphilis are the best characterized and widely recognized causes of MN. However, other chronic infections have also been associated with MN, including malaria, which is the most common cause of MN worldwide. Certain medications, such as penicillamine and gold, can also cause MN. Rarely, tumors, such as neuroblastoma, or other idiopathic systemic diseases have been associated with MN. Identification of secondary causes of MN is critical, because removal of the offending agent or treatment of the causative disease often leads to resolution of the associated nephropathy and improves patient outcome.


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