Intrapulmonary Shunting and Deadspace

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Intrapulmonary Shunting and Deadspace

Spectrum of Ventilation/Perfusion (image/image) Abnormalities (Figure 8-1)

II Intrapulmonary Shunting

A pathophysiologic process in which blood enters the left side of the heart without having been oxygenated by the lungs. The mixing of venous blood with oxygenated blood from the pulmonary capillaries to form arterial blood.

The total quantity of shunted blood is the physiologic shunt, which is composed of three subdivisions (Figure 8-2).

1. Anatomic shunt: The portion of the total cardiac output that bypasses the pulmonary capillary bed.

2. Capillary shunt: The portion of the total cardiac output that perfuses nonventilated alveoli (Figure 8-3).

3. Shunt effect (ventilation/perfusion inequality, low image/image, venous admixture): Any pathophysiologic process in which perfusion is in excess of ventilation; however, some ventilation is still present (Figure 8-4).

III Derivation of Classic Shunt Equation

Definition of abbreviations

1. imageo2: Volume of oxygen consumed per minute

2. images: Shunted cardiac output

3. imagec: Capillary cardiac output

4. imaget: Total cardiac output

The shunt equation is based on the Fick equation, which normally is used to calculate oxygen consumption or cardiac output:

< ?xml:namespace prefix = "mml" />V˙o2=Q˙t(Cao2Cvo2) (1)

image (1)

Because actual capillary blood flow (imagec) represents the portion of the cardiac output that actually perfuses ventilated alveoli and Cco2 is the oxygen content of blood leaving those perfused and ventilated alveoli, this equation may be rewritten as:

V˙o2=Q˙c(Cco2Cvo2) (2)

image (2)

Thus total cardiac output is equal to shunted cardiac output plus capillary cardiac output:

Q˙t=Q˙s+Q˙c (3)

image (3)

Solving equation 3 for imagec:

Q˙c=Q˙t+Q˙s (4)

image (4)

Substituting into equation 2 the equivalent of imageo2 from equation 1:

Q˙t(Cao2Cv¯o2)=Q˙c(Cco2Cv¯o2) (5)

image (5)

Substituting into equation 5 the equivalent of imagec from equation 4:

Q˙t(Cao2Cvo2)=(Q˙tQ˙s)(Cco2Cvo2) (6)

image (6)

Rearranging equation 6:

Q˙t(Cao2Cvo2)=(Q˙tQ˙s)(Cco2Cvo2) (7)

image (7)

Eliminating −imagetCimageo2 from both sides of equation 7:

Q˙t(Cao2Cvo2)=(Q˙tQ˙s)(Cco2Cvo2) (8)

imagetCao2 = imagetCco2image Cco2 + image sCimageo2 (8)

Rearranging equation 8:

Q˙t(Cao2Cvo2)=(Q˙tQ˙s)(Cco2Cvo2) (9)

imagesCco2imagesCimageo2 = imagetCco2 + imagetCao2 (9)

Simplifying equation 9:

Q˙t(Cao2Cvo2)=(Q˙tQ˙s)(Cco2Cvo2) (10)

images(Cco2 − Cimageo2) = imaget(Cco2 − Cao2) (10)

Rearranging equation 10:

Q˙s/Q˙t=Cco2Cao2Cco2Cvo2 (11)

image (11)

Equation 11 is the classic shunt equation, which states that the difference between the capillary oxygen content and arterial oxygen content divided by the difference between the capillary oxygen content and the mixed venous oxygen content equals the intrapulmonary shunt fraction.

This equation is used to calculate the total physiologic shunt.

IV Calculation of the Total Physiologic (or Intrapulmonary) Shunt

The intrapulmonary shunt is determined by calculating the capillary oxygen content, arterial oxygen content, and mixed venous oxygen content.

All oxygen content determinations are based on the following equation:

Q˙s/Q˙t=Cco2Cao2Cco2Cvo2 (12)

o2 content (vol%) = (Hb cont)(Hbo2% sat)(1.34) + (0.003)(Po2) (12)

Calculation of the arterial oxygen content requires data from an arterial blood gas.

Calculation of the mixed venous oxygen content requires data from a pulmonary artery blood gas.

Capillary oxygen content

1. Because a blood sample from an ideally functioning alveolar-capillary unit is impossible to obtain, this calculation is based on the assumption that the end pulmonary capillary oxygen tension (Pco2) is equal to the alveolar oxygen tension (Pao2) in an ideally ventilated and perfused alveolar-capillary unit.

2. The Pao2 is obtained by calculation, using the ideal alveolar gas equation (see Chapter 5):

PAO2=(PBPH2O)(F1O2)(Paco2)(F1O2+1F1O2R) (13)

image (13)

3. Hemoglobin content is the same as that measured in arterial blood or mixed venous blood.

4. Oxyhemoglobin percent saturation (Hbo2% sat)

Example:

Cao2=17.5vol%Cco2=19.5vol%Cvo2=13.0vol%Q˙sQ˙t=Cco2Cao2Cco2Cvo2Q˙sQ˙t=19.517.519.513.0=0.31

image

    or 31% intrapulmonary shunt.

Estimated Intrapulmonary Shunt Calculation

In patients without a pulmonary artery catheter, it is impossible to measure the Cimageo2.

However, in the majority of critically ill patients with cardiovascular stability, it has been determined that the Cao2 − Cimageo2 is approximately 3.5 vol%.

Thus in these patients 3.5 vol% may be used as an estimate of Cao2 − Cimageo2.

The denominator of the classic shunt equation may be expressed as follows:

Cao2=17.5vol%Cco2=19.5vol%Cvo2=13.0vol%Q˙sQ˙t=Cco2Cao2Cco2Cvo2Q˙sQ˙t=19.517.519.513.0=0.31 (14)

Cco2 − Cimageo2 = Cco2 − Cao2) + (Cao2 − Cimageo2) (14)

Because Cao2 − Cimageo2 is estimated at 3.5 vol%, the denominator in equation 11 can be expressed as:

Cao2=17.5vol%Cco2=19.5vol%Cvo2=13.0vol%Q˙sQ˙t=Cco2Cao2Cco2Cvo2Q˙sQ˙t=19.517.519.513.0=0.31 (15)

(Cco2 − Cao2) + 3.5 (15)

The modified shunt equation used to estimate intrapulmonary shunt is:

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (16)

image (16)

Equation 16 should be used only if pulmonary artery blood is unavailable and the patient is cardiovascularly stable.

VI FIO2 Used to Calculate Percent Intrapulmonary Shunt

Historically shunt fractions were determined at an FIO2 of 1.0.

However, it has been demonstrated that the shunt fraction is increased at an FIO2 of 1.0.

This occurs secondary to:

1. Nitrogen washout atelectasis

a. Areas of the lung that are ventilated poorly tend to collapse if the nitrogen is removed.

b. Nitrogen normally maintains alveolar stability. When nitrogen is removed and replaced by oxygen, the blood absorbs the oxygen faster than it can be replaced because of the poor ventilation.

c. As a result, alveolar size decreases, eventually falling below its critical volume, and collapse occurs (Figure 8-5).

2. Redistribution of pulmonary blood flow

Figure 8-6 represents the relationship between FIO2 and percent shunt. Clinically it appears that the lowest measured shunt occurs at approximately 50% oxygen.

Percent intrapulmonary shunts should be calculated at the FIO2 the patient is maintained and at 100% oxygen so that the quantity of venous admixture contributing to the total shunt faction can be determined by the difference between the two.

VII Clinical Use of the Shunt Calculation

Differentiating causes of hypoxemia

2. The numerator of the shunt equation, Cco2 − Cao2, can be considered a reflection of intrapulmonary pathology (i.e., hypoxemia of pulmonary origin will increase the Cco2 − Cao2 value, increasing the calculated shunt fraction).

3. The denominator in the shunt equation, Cco2 − Cao2, can be considered a reflection of the relationship of cardiac output to oxygen demand.

4. Hypoxemia accompanied by an increased shunt measurement generally denotes an increase in intrapulmonary pathology.

5. Hypoxemia without a major increase in shunt fraction usually denotes cardiovascular causes of hypoxemia.

Assessment of spontaneous ventilatory capabilities in patients being mechanically ventilated

1. An intrapulmonary shunt determination of <10% during mechanical ventilation is clinically comparable with normal lungs.

2. An intrapulmonary shunt determination of 10% to 19% should not represent sufficient pulmonary disease to interfere with spontaneous ventilation.

3. An intrapulmonary shunt of 20% to 30% may result in ventilatory failure in patients with central nervous system or cardiovascular dysfunction if spontaneous ventilation is attempted. However, many patients are able to sustain spontaneous ventilation with this level of shunt.

4. An intrapulmonary shunt of >30% represents a degree of pulmonary disease that normally requires aggressive cardiopulmonary support (i.e., increased positive end-expiratory pressure [PEEP], lung recruitment, fluid therapy, and prone positioning).

Assessment of specific cardiopulmonary abnormalities

Monitoring of oxygen and PEEP therapy

1. If the hypoxemia is of pulmonary origin and caused primarily by shunt effect, the appropriate application of oxygen therapy should demonstrate a decrease in intrapulmonary shunt.

2. If the hypoxemia is of pulmonary origin and caused primarily by capillary shunting of a generalized diffuse nature (e.g., acute respiratory distress syndrome [ARDS]), lung recruitment maneuvers, PEEP therapy, and prone positioning are primarily indicated, along with appropriate adjustment of FIO2.

3. However, the greater the percent intrapulmonary shunt, the less effect increasing FIO2 has on Pao2 (Figure 8-7).

image
FIG. 8-7 Comparison of the theoretical FIO2-Pao2 relationships in 0%, 15%, and 30% true shunts. These relationships were calculated assuming normal lung ventilation, hemoglobin of 15 g%, arteriovenous oxygen content difference of 5 vol%, and normal cardiac output, metabolic rate, pH, and PCO2. This schema assumes that only true shunting exists (i.e., no shunt effect is present). The 0% true shunt line reveals a Pao2 of 100 mm Hg at room air. There is a predictable increase in Pao2 for incremental increases in FIO2 because the arterial hemoglobin is nearly fully saturated at room air. Because all the blood exchanges with alveolar gas, incremental increases in alveolar oxygen tensions produce similar increases in arterial oxygen tensions. Note that with 15% true shunt, the arterial PO2 is approximately 60 mm Hg (90% saturation) because 15% of the cardiac output enters the left side of the heart with approximately 75% hemoglobin saturation. Incremental increases in alveolar PO2 result in small increases in oxygen content (dissolved oxygen) in 85% of the cardiac output, whereas 15% of the cardiac output continues to enter the left side of the heart with a hemoglobin saturation of approximately 75%. Note that the arterial blood does not approach 100 mm Hg (near complete hemoglobin saturation) until the FIO2 approaches 0.5. With incremental FIO2 increases >0.5, near linear increases in Pao2 occur but at a slightly lesser slope than with 0% true shunt. Thirty percent true shunt produces an arterial PO2 of approximately 45 mm Hg at room air. This degree of true shunt does not allow an arterial PO2 of 100 mm Hg, even at 100% inspired oxygen concentration.

4. In patients with >30% images/imaget, FIO2 of 1.0 may not increase the Po2 to a clinically acceptable level.

VIII Other Methods of Estimating Shunting and Oxygenation Status (Table 8-1)

TABLE 8-1

Methods of Calculating or Estimating Shunt

Index Normal Value Abnormal Value Limitations
images/imaget 2-5% >10% Invasive
P(A− a)O2 7-14 mm Hg (RA) 100-150 at FIO2 1.0 Varies with FIO2
31-56 mm Hg (1.0)
Pao2/PaO2 >0.75 <0.75 ——
Pao2/FIO2 450-500 <300-350 Varies with Paco2 and FIO2

image

RA, Room air; 1.0, 100% O2.

Alveolar-arterial Po2 difference: P(A−a)o2

Arterial-alveolar ratio: Pao2/Pao2

Arterial-FIO2 ratio: Pao2/FIO2

IX Pulmonary Deadspace

Pulmonary deadspace is the portion of the total ventilation that does not undergo external respiration.

The total quantity of pulmonary deadspace is the physiologic deadspace and is composed of three subdivisions:

1. Anatomic deadspace: The portion of the total ventilation that does not contact the alveolar epithelium.

2. Alveolar deadspace: The portion of the total ventilation that contacts the alveolar epithelium but does not participate in gas exchange because of a lack of pulmonary capillary blood flow (Figure 8-8).

3. Deadspace effect (ventilation/perfusion inequality): Any pathophysiologic process in which ventilation is in excess of perfusion but some perfusion does exist (i.e., image/image ratio >1.0) (see Figure 8-8).

Derivation of the Deadspace Equation

Definition of abbreviations

Tidal volume is equal to deadspace volume plus alveolar volume.

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (17)

Vt = Vd + Va (17)

The total volume of Co2 in exhaled gas is equal to Vt times the fractional concentration of Co2 in the exhaled gas.

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (18)

(Vt)(FĒco2) = total Co2 exhaled (18)

This volume can be subdivided into the amount of Co2 exhaled from deadspace and alveoli:

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (19)

(Vt)(FĒco2) = (Va)(Faco2) + (Vd)(Fdco2) (19)

Because the concentration of Co2 in exhaled deadspace gas is approximately zero, equation 19 can be rewritten as:

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (20)

(Vt)(FĒco2) = (Va)(Faco2) (20)

Because Va = Va − Vd, equation 20 may be rewritten as:

Q˙sQ˙t=Cco2Cao2(Cco2Cao2)+3.5 (21)

(Vt)(FĒco2) = (Vt)(Faco2) − (Vd)(Faco2) (21)

By rearrangement of and simplification of equation 21, the Bohr equation for the determination of the deadspace/tidal volume ratio (Vd/Vt ratio) is generated.

    

VD/VT=FACO2FECO2FACO2 (22)

image (22)

Because the concentration of Co2 in the alveoli is equal to the concentration of Co2 in the arterial blood and because the partial pressures of gases are proportional to their concentration, equation 22 may be rewritten as the Enghoff modification of the Bohr equation:

VD/VT=Paco2PECO2PaCO2 (23)

image (23)

In all circumstances, as the deadspace increases, there is a widening of the Paco2 − PĒco2 gradient.

Normal Vd/Vt ratios are approximately 20% to 40%.

XI Calculation of the Deadspace/Tidal Volume Ratio

XII Minute Volume–Paco2 Relationship

Because the arterial Paco2 level clinically defines the physiologic adequacy of ventilation, a relationship between total minute volume and arterial Paco2 must exist.

In the average adult, a minute volume of 4 to 6 L maintains a Paco2 of 40 mm Hg.

If the minute volume increases, the Paco2 should decrease, and if the minute volume decreases, the Paco2 should increase.

It is generally accepted that with each doubling of the minute volume, the Paco2 decreases by approximately 10 mm Hg (Table 8-2).

TABLE 8-2

Normal Minute Volume–Paco2 Relationship

VA(L/min) Paco2 (mm Hg)
1.25 60
2.50 50
5.00 40
10.00 30
20.00 20

image

If there is a disparity between the minute volume and the expected Paco2, deadspace is most probably increased.

    Example:

XIII Clinical Use of the Deadspace/Tidal Volume Ratios

XIV Guidelines for Differentiating Shunt-Producing From Deadspace-Producing Diseases

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