Human Blood Group Antigens and Antibodies

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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Chapter 50 Human Blood Group Antigens and Antibodies

Connie M. Westhoff, Jill R. Storry, Beth H. Shaz

Table 50-1 Blood Group Systems, Antigens, Expression, and Disease Associations

IgSF, Immunoglobulin super family; ISGN, International Society for Gene Nomenclature; type I, protein with a single pass through the RBC lipid bilayer with its amino terminus to the outside of the cell; type II, protein with a single pass through the RBC lipid bilayer with its amino terminus to the inside of the cell.

Table 50-2 Uses of DNA-Based Genotyping Assays for Transfusion Medicine

Type patients who have been recently transfused

Type RBCs coated with immunoglobulin

Type patients with AIHA (to select antigen-negative RBCs for transfusion and absorption of autoantibodies when searching for under-lying alloantibodies)

Type RBCs when commercial antisera are not available

Type for numerous blood group antigens in a single assay

Identify weak D and partial D (to determine candidate for Rh immune globulin or avoid use of limited Rh-negative donor supply)

Resolve blood group typing discrepancies

Determine paternal zygosity for RHD and HPA

Type fetus to determine risk for HDFN or NAIT