Chapter 22 Habit and Tic Disorders
Habit Disorders
Clinical Manifestations
Trichotillomania is the repetitive pulling of hair resulting in loss and strand breakage of hair (Chapter 654). The usual age of onset of trichotillomania is around 13 yr, although preschoolers have been described with this disorder. Children with trichotillomania have an increasing sense of tension immediately before pulling or when resisting the behavior, followed by pleasure or relief when pulling out the hair. The prevalence of trichotillomania in children is not well known but is believed to be 1-2% in college students. Although trichotillomania often remits spontaneously, treatment of those whose disorder has been present for >6 mo is unlikely to remit and requires behavioral treatment. Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine have some success as adjuncts.
Tic Disorders
Tourette’s disorder (TD) or syndrome (TS) is characterized by multiple motor and one or more vocal tics that have been present at some time in the illness, although not necessarily concurrently (Chapter 590.4). The tics occur many times a day nearly every day for more than 1 yr with no more than 3 consecutive tic-free months. Chronic motor or vocal tic disorder is similar, but each does not include both kinds of tics. Transient tic disorder involves motor and/or vocal tics that have been present for at least 4 wk, but less than 1 yr.
Diagnosis and Differential Diagnosis
TD and associated tic disorders must be differentiated from abnormal movements that might accompany a general medical condition (e.g., head injury, Huntington’s disease) or the direct effects of a substance (e.g., neuroleptic medication). They are different from the stereotyped movements seen in habit (or stereotypic movement) and pervasive developmental disorders. Tics must be differentiated from the compulsions seen in OCD (Chapter 23). Certain medications (e.g., stimulants) can exacerbate a pre-existing tic disorder.
Etiology
Autoimmune-mediated mechanisms continue to be investigated as having a potential etiologic role in movement disorders. Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) is a condition in which antibodies to group A streptococcus (Chapter 176) cross-react with basal ganglia tissue and precipitate symptoms. Data supporting the pathophysiology of PANDAS include the ability to prevent tic relapses with antibiotic prophylaxis; high rates of cross-reactive antibodies for both group A streptococcus and basal ganglia proteins found in some samples from patients with tics compared with control subjects; and enlargement of the basal ganglia during acute exacerbations of neuropsychiatric symptoms in patients with PANDAS. Five clinical characteristics define the subgroup of patients with PANDAS: the presence of OCD and/or tic disorder; prepubertal age of onset; abrupt onset and relapsing-remitting course; association with neurologic abnormalities (chorea, hyperactivity, tics) during exacerbations; and temporal association between symptom exacerbations and group A streptococcal infection (a positive antistreptolysin O titer). Treatment of PANDAS includes acute antistreptococcal antibiotic therapy; prophylactic penicillin or azithromycin can decrease the number or episodes. The role of immunotherapy is controversial, with therapeutic plasma exchange indicated only for severely affected children.
Treatment
Medication for tic reduction is reserved for when the tics cause marked distress or significant impairments in psychosocial functioning. The α2-adrenergic agonists (clonidine and guanfacine) are first-line agents in treating mild to moderate tic disorders. Sedation and low blood pressure are common side effects that require careful monitoring particularly when initiating treatment. The D2 dopamine receptor-blocking medications (haloperidol and pimozide) are effective in reducing tics, but side effects including extrapyramidal symptoms have limited their use as first-line treatment. Risperidone, an atypical antipsychotic medication, has been shown to be equivalent to clonidine in reducing tics, though it too can have extrapyramidal as well as metabolic side effects (see Table 19-5).
Tourette’s Syndrome
Clinical Manifestations
Children with TS often have behavioral, emotional, and academic problems. In particular, these children have higher rates of OCD (Chapter 23), ADHD (Chapter 30), and oppositional-defiant disorder (Chapter 27). The fact that TS is highly comorbid with these specific psychiatric disorders suggests dysfunction in particular regions of the brain. Neuroimaging studies suggest that there is a lack of normal asymmetry within the striatum and a decrease in the size of the cavum septum pellucidum. Single-photon emission computed tomography (SPECT) scan data implicate dysfunction in dopamine receptor binding in severely affected children. Studies have also implicated systemic and local cytokine responses in TS and in the exacerbation of symptoms.
Lyme disease rarely occurs with clinical manifestations of TS (Chapter 214). Many environmental factors are emotional stressors, which can also precipitate or increase tics. Laboratory studies are nonspecific; many patients with TS have nonspecific abnormal electroencephalographic findings.
Treatment
Pharmacotherapy, targeting the tics themselves, is indicated when tics interfere with social development or classroom function. For 1st-line treatment, haloperidol and pimozide reduce the severity of tics by 65%. Because potentially severe side effects are associated with traditional neuroleptics (cognitive impairment, lethargy, depression, dystonic reactions, parkinsonism, tardive dyskinesia), many clinicians recommend risperidone. Risperidone is equivalent to clonidine in reducing tics. Clonidine, an α2-agonist, is effective; sedation and low blood pressure are common side effects of clonidine and require careful monitoring. The role of guanfacine (Tenex), which is a less sedating α2-agonist, has not been firmly established (see Table 19-5).
Affected children and their families should be encouraged to be active participants in the management of TS. Support from organizations such as the Tourette Syndrome Association, which has a user-friendly website (www.tsa-usa.org), is often very beneficial to affected families. The natural course of TS includes a significant diminution or remission in symptoms in adolescence and early adulthood in approximately 65% of cases. It is difficult to predict which patients will experience fewer symptoms over time.
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