Published on 27/03/2015 by admin
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Chapter 511 Goodpasture Disease
Scott K. Van Why, Ellis D. Avner
Goodpasture disease is characterized by pulmonary hemorrhage and glomerulonephritis. The disease results from the attack of these normal organs by antibodies directed against specific epitopes of type IV collagen within the alveolar basement membrane in the lung and glomerular basement membrane (GBM) in the kidney. The etiology of these antibodies is unknown.
Kidney biopsy shows crescentic glomerulonephritis in most patients. Immunofluorescence microscopy demonstrates continuous linear deposition of immunoglobulin G along the GBM (Fig. 511-1).
Figure 511-1 Immunofluorescence micrograph demonstrating the continuous linear staining of immunoglobulin G along the glomerular basement membrane in Goodpasture disease (×250).
Nelson Textbook of Pediatrics Expert Consult
