Future Cosmeceuticals of Dermatologic Importance

Published on 15/03/2015 by admin

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Last modified 15/03/2015

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Chapter 32 Future Cosmeceuticals of Dermatologic Importance

GENISTEIN

Genistein is a soybean isoflavone that was first isolated from soy beans in 1931. It is a potent antioxidant with specific inhibitors of protein tyrosine, kinase, and phytoestrogens, increasing the thickness of the skin through an estrogenic effect. It has been found that it exhibits properties preventing the hemolysis of red blood cells by dialuric acid or H2O2 and inhibiting microsomal lipid peroxidation induced by Fe2+-ADP complex and NAPDH. It is the most potent inhibitor of P450-mediated activation of benzo[a]pyrene among all isoflavones.

Multiple studies over the past decade have given support to the belief that these natural ingredients have preventive and therapeutic effects on breast and prostate cancers, osteoporosis, cardiovascular diseases (in humans and animals), and postmenopausal syndrome. Genistein has significant effects in terms of inhibition of chemical carcinogenesis, UV-induced skin carcinogenesis and photo-damage in both humans and mice.

Although numerous in vitro studies have shown its potential in anticancer properties, evidence is lacking on its effect on skin carcinogenesis, but there is scientific support for its potential. Genistein has been found to have chemopreventive and strong anticancer activities. It has been shown to inhibit the activity of tyrosine protein kinase (TPK), topoisomerase II (Topo II), and ribosomal S6 kinase (RS6K) in cell culture. It has also been shown to inhibit growth of the ras oncogene and decrease PD6F-induced c-fos and c-jun expression in fibroblasts. Experiments were conducted to prove that genistein substantially blocks subacute and chronic UVB- and PUVA-induced cutaneous damage (Box 32.1; Figs 32.2 and 32.3).

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