Euthyroid sick syndrome

Published on 02/03/2015 by admin

Filed under Endocrinology, Diabetes and Metabolism

Last modified 02/03/2015

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CHAPTER 39

Euthyroid sick syndrome

1. What is euthyroid sick syndrome?

2. What hormone changes occur in patients with mild to moderate nonthyroidal illnesses?

3. Describe the hormone changes in patients with moderate to severe nonthyroidal illnesses.

4. Describe the hormone changes associated with recovery from nonthyroidal illnesses.

5. How can euthyroid sick syndrome be distinguished from hypothyroidism?

6. What causes euthyroid sick syndrome?

7. What is the function of the deiodinase enzymes?

Deiodinases are selenocysteine enzymes that activate and deactivate thyroid hormones by removing iodine molecules. Deiodinase enzymes have three known subtypes: D1, deiodinase 2 (D2), and deiodinase 3 (D3) (Table 39-1 and Fig. 39-1). D1 converts T4 to T3 in the liver and kidneys, thus producing the majority of circulating T3, and converts reverse T3 (rT3

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