31 Epilepsy
Epidemiology
Epilepsy does impact on an individual’s human rights, for example, access to health and life insurance is affected. A person who suffers from epilepsy may not be able to obtain a driving licence and it has an impact on the choice of career. In addition, legislation can impact on the life of individuals with epilepsy, for example, in some countries epilepsy may deter marriages. Legislation based on internationally accepted human rights standards can prevent discrimination and rights violations, improve access to health care services and raise quality of life (WHO, 2009). A global campaign has been established to raise awareness about epilepsy, provide information and highlight the need to improve care and reduce the disorder’s impact through public and private collaboration. This is supported through a partnership established between WHO, the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE).
Clinical manifestations
Partial or focal seizures
Secondarily generalised seizures
There have been recent proposals to revise the concepts, terminology and approaches for classifying seizures and forms of epilepsy (Berg et al., 2010). In this proposal, the so-called natural classes, for example, specific underlying cause, age at onset, associated seizure type; or pragmatic groupings, for example, epileptic encephalopathies, self-limited electroclinical syndromes, serve as the basis for classification.
Treatment
National Institute for Health and Clinical Excellence (2004a) issued guidance on the diagnosis and treatment of the epilepsies in adults and children in primary and secondary care. The guidance covered issues such as when a person with epilepsy should be referred to a specialist centre, the special considerations concerning the care and treatment of women with epilepsy and the management of people with learning disabilities. The key points of the guidance are summarised in Box 31.1.
Box 31.1 Key points on the diagnosis and management of epilepsy (National Institute for Health and Clinical Excellence, 2004a)
Treatment during seizures
Long-term treatment
Initiating treatment with an AED is a major event in the life of a person, and the diagnosis should be unequivocal. Treatment options must be considered with careful evaluation of all relevant factors, including the number and frequency of attacks, the presence of precipitating factors such as alcohol, drugs or flashing lights, and the presence of other medical conditions (Feely, 1999). Single seizures do not require treatment unless they are associated with a structural abnormality in the brain, a progressive brain disorder or there is a clearly abnormal EEG recording. If there are long intervals between seizures (over 2 years), there is a case for not starting treatment. If there are more than two attacks that are clearly associated with a precipitating factor, fever or alcohol for instance, then treatment may not be necessary.
General principles of treatment
Therapy aims to control seizures using one drug, with the lowest possible dose that causes the fewest side effects possible. The established AEDs, carbamazepine, ethosuximide and sodium valproate, are still important parts of the antiepileptic armamentarium. Acetazolamide, clobazam, clonazepam, phenobarbital phenytoin and primidone are also still used. In the last two decades, new AEDs such as vigabatrin, lamotrigine, gabapentin, topiramate, tiagabine, oxcarbazepine, levetiracetam, pregabalin, zonisamide, lacosamide and eslicarbazepine acetate have been introduced. The choice of drugs depends largely on the seizure type, and so correct diagnosis and classification are essential. Table 31.1 lists the main indications for the more commonly used AEDs, and Table 31.2 summarises the clinical use of the newer AEDs.
Seizure type | First-linetreatment | Second-line treatment |
---|---|---|
Partial seizures | ||
Carbamazepine | Topiramate | |
Lamotrigine | Valproate |