Well-defined, smoothly marginated, round/oval submucosal mass with central umbilication
Reflux of contrast into rudimentary duct-like structure may extend below central pit
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CT findings
Often too small to be detected
Round or oval mass with protrusion into gut lumen
May have well-defined or ill-defined margins on CT
Enhancement pattern is variable
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Acini-dominant ectopic pancreas shows homogeneous, avid enhancement
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Others types more heterogeneous (or even cystic)
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Overlying mucosa of bowel often avidly enhancing
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MR findings: Ectopic pancreas is isointense on all pulse sequences with main pancreas (including DWI/ADC)
TOP DIFFERENTIAL DIAGNOSES
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Other gastric hypervascular submucosal lesions (glomus tumor, carcinoid, GIST)
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Gastric metastases and lymphoma
CLINICAL ISSUES
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Most patients are asymptomatic and ectopic pancreas is usually an incidental finding
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Can be complicated by bleeding or mucosal ulceration and patients present with epigastric pain and melena
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Can undergo any of the inflammatory or neoplastic abnormalities of main pancreas including acute/chronic pancreatitis and development of malignancy
TERMINOLOGY
Abbreviations
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Ectopic pancreatic tissue (EPT)
Synonyms
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Pancreatic rests; heterotopic, aberrant, accessory pancreas
Definitions
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Pancreatic tissue located outside of normal confines of pancreas and lacking any anatomic or vascular connection with main pancreas
IMAGING
General Features
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Best diagnostic clue
Small submucosal gastric mass with central umbilication
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Central umbilication (45% of cases): Orifice of rudimentary duct through which ectopic pancreatic tissue (EPT) drains into gastric lumen
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Location
90% of all cases found in upper GI tract (stomach, duodenum, or proximal jejunum)
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Most commonly gastric antrum (< 6 cm from pylorus)
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Can rarely arise in ileum, Meckel diverticulum, liver, biliary tract, spleen, omentum, mesentery, lung, mediastinum, fallopian tube, esophagus, colon
Primarily arise in submucosa (73%); can also be located in muscular layer (17%) or subserosa (10%)
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2nd most common gastric submucosal mass (behind only mesenchymal lesions such as GI stromal tumors)
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Size
Nodule: 0.5-2 cm; may be up to 5 cm in diameter
Pit: May be 5 mm in diameter and 10 mm in length
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Morphology
Submucosal layer: Appears as well-defined flat or nodular projection into gut lumen with intact overlying mucosa
Muscularis or subserosal layers: Produces smooth bulge or area of wall thickening
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Diagnostic Imaging_ Gastrointes - Michael P Federle