Echinococcosis (Echinococcus granulosus and Echinococcus multilocularis)

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Chapter 296 Echinococcosis (Echinococcus granulosus and Echinococcus multilocularis)

Etiology

Echinococcosis (hydatid disease or hydatidosis) is the most widespread, serious human cestode infection in the world (Fig. 296-1). Two major Echinococcus species are responsible for distinct clinical presentations, E. granulosus (cystic hydatid disease) and the more malignant E. multilocularis (alveolar hydatid disease). The adult parasite is a small (2-7 mm) tapeworm with only 2-6 segments that inhabits the intestines of dogs, wolves, dingoes, jackals, coyotes, and foxes. These carnivores pass the eggs in their stool, which contaminates the soil, pasture, and water, as well as their own fur. Domestic animals such as sheep, goats, cattle, and camels ingest E. granulosus eggs while grazing. Humans are also infected by consuming food or water contaminated with eggs or by direct contact with infected dogs. The larvae hatch, penetrate the gut, and are carried by the vascular or lymphatic systems to the liver, lungs, and less commonly bones, brain, or heart.

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Figure 296-1 Worldwide distribution of cystic echinococcosis.

(From McManus DP, Zhang W, Li J, et al: Echinococcosis, Lancet 362:1295–1304, 2003.)

E. granulosus shows high intraspecific variation. One distinct variant is found in a sylvatic wolf/moose cycle in North America and Siberia. The transmission cycle of E. multilocularis is similar to that of E. granulosus, except that this species is mainly sylvatic and uses small rodents as its natural intermediate hosts. The rodents are consumed by foxes, their natural predators, and sometimes by dogs and cats.