Metastases: Bull’s-eye or “target” lesion; submucosal or polypoid mass
Lymphoma: Bulky submucosal mass without obstruction
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Best imaging tool: Upper GI series, CECT
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Metastases: “Target” or bull’s-eye lesion with rounded submucosal mass
Luminal obstruction and ulceration are common
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Lymphoma: Large smooth or lobulated submucosal mass
Aneurysmal dilation of lumen without obstruction
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Direct invasion: From primary cancer of pancreas, colon, kidney, gallbladder
TOP DIFFERENTIAL DIAGNOSES
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Villous adenoma, duodenal carcinoma, secondary duodenal invasion, duodenal GIST
PATHOLOGY
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Etiology
Metastases: Melanoma, cancer of breast, lung, colon, pancreas, or kidney
Lymphoma: Non-Hodgkin lymphoma of B-cell origin or mucosa-associated lymphoid tissue
CLINICAL ISSUES
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Most common signs/symptoms: Abdominal pain, nausea, vomiting, weight loss, palpable mass, upper GI bleeding
DIAGNOSTIC CHECKLIST
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Consider duodenal carcinoma (usually obstructs lumen)
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Lymphoma: Bulky submucosal mass without obstruction
TERMINOLOGY
Definitions
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Involvement of duodenum with malignant lymphoma or metastatic disease
IMAGING
General Features
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Best diagnostic clue
Metastases: Bull’s-eye or “target” lesion; submucosal or polypoid mass
Lymphoma: Bulky submucosal mass without obstruction of lumen
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Location
Submucosal lesion in any portion of duodenum
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Size
1-5 cm
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Morphology
Lymphoma: Smooth submucosal, often bulky mass
Fluoroscopic Findings
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Upper GI
Metastases: “Target” or bull’s-eye lesion with rounded submucosal mass; luminal obstruction and ulceration are common
Related
Diagnostic Imaging_ Gastrointes - Michael P Federle