Diagnostic Classification Systems

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CHAPTER 6 Diagnostic Classification Systems

Diagnostic classification systems (DCSs) for children’s developmental and behavioral problems are important in clinical care, teaching, consultation, and research in the field of developmental-behavioral pediatrics. In order to conduct diagnosis and treatment planning, teaching, and research, clinicians with an interest in developmental and behavioral problems need to understand DCSs that are appropriate for children and adolescents. As specialists, developmental-behavioral pediatricians are called on to conduct comprehensive diagnosis and treatment planning for children and adolescents who present with a wide range of behavioral and developmental problems.1 Reimbursement for clinical practice is also tied to specific codes that are used for purposes of diagnostic classification.2 Clinicians with expertise in developmental and behavioral problems are also called on to teach pediatricians and members of other professional disciplines to diagnose and manage these problems.3 Finally, research on the diagnosis and treatment of children with developmental and behavioral problems requires knowledge of the reliability and validity of DCSs.

The purpose of this chapter is to summarize the state of the art with regard to diagnostic classification of children and adolescents with behavioral and emotional problems. We consider challenges in diagnosis, history of classification of mental disorders, systems for classification, and future research directions.

CHALLENGES OF DIAGNOSIS IN DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Practitioners, consultants, teachers, and researchers with involvement in developmental and behavioral problems may be interested in any number of questions that relate to various functions of a DCS. Relevant clinical questions include the following: How well does a DCS capture the range of symptoms and functional problems of children and adolescents that are seen in practice? How does a DCS facilitate treatment planning for children and adolescents who are seen in practice and facilitate communication and consultation with parents, providers, and systems of care?

Clinicians are also interested in how DCSs can facilitate the teaching and training of pediatricians and other professionals to diagnose and manage clinical problems. Relevant research questions include the interrater reliability and validity of the DCS, stability of diagnosis and prognosis over time, and the functional significance or validity of the diagnostic criteria.4

The complexity of the diagnosis and treatment of developmental and behavioral problems in children and adolescents presents significant challenges for any DCS. For example, children and adolescents present to clinical attention with an extraordinary number of developmental and behavioral problems that involve a wide range of symptoms that can affect functioning in different domains. The expression and severity of problems and symptoms vary dramatically as a function of the child’s age, as do normative developmental expectations for behaviors and symptoms.5 Moreover, the functional consequences of specific behavioral and developmental problems and diagnoses also vary widely in ways that may or may not be captured by a DCS.6 Finally, available scientific data concerning the validity of specific diagnostic categories also vary with DCSs and specific conditions.

SYSTEMS FOR DIAGNOSTIC CLASSIFICATION OF DEVELOPMENTAL AND BEHAVIOR PROBLEMS

A number of alternative DCSs can be used by clinicians with an interest in developmental and behavioral problems of children and adolescents to diagnose and treat these problems. We now describe several diagnostic classifications and their potential relevance to practice, teaching, and research.

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)

HISTORY

In the United States, the initial interest in developing a classification of disorders started in the 1800s in order to collect statistical information. In 1840, this consisted of recording the category of idiocy or insanity. By 1880, the census distinguished between mania, melancholia, monomania, paresis, dementia, dipsomania, and epilepsy. In 1917, the American Medico-Psychological Association (a forerunner of the American Psychiatric Association [APA]) adopted a plan to collect uniform information across mental hospitals. The APA subsequently collaborated with the New York Academy of Medicine to develop a nationally acceptable nomenclature that was incorporated into the first edition of the American Medical Association’s Standard Classified Nomenclature of Disease. Later, a broader nomenclature was developed by the U.S. Army in order to better incorporate the outpatient presentations of veterans of World War II. At around the same time, the World Health Organization published the sixth edition of its International Classification of Diseases (ICD-6), which for the first time included a mental disorders section that included psychoses (10 categories); psychoneuroses (9 categories); and disorders of character, behavior, and intelligence (7 categories).

The APA published a variation of the ICD-6 mental disorders categories in 1952, as the first edition of the Diagnostic Statistical Manual of Mental Disorders (DSM), and it was first revised in 1967.7 Both of these editions were influenced predominantly by a psychoanalytic approach, and the term reaction was used for many of the disorders, more so in the first edition. For example, in 1967, what is now defined as attention-deficit/hyperactivity disorder (ADHD) was still labeled hyperkinetic reaction of childhood. The classificatory structure was organized with two poles: psychosis on the severe end, characterized by a disconnection with reality and typically manifested by hallucinations, delusions, and illogical thinking, and neurosis at the mild end, characterized by distortions of reality and typically manifested by anxiety and depression.

In 1980, when the DSM was revised to the third edition,8 the psychodynamic view was discarded, and a biomedical model became the principal approach. The system included explicit diagnostic criteria and a multiaxial system. The revised system tried to make a clear distinction between normal and abnormal. The revision of the third edition, DSM-III-R,9 was published in 1987 and was based on additional research and consensus. It was subsequently revised again in 1994 as the fourth edition (DSM-IV),10 in part to develop compatibility between the DSM system and the tenth edition of the International Classification of Diseases (ICD-10).11 Additional revisions in the text were published in 2000 without any substantial changes in the disorder characteristics (DSM-IV-TR).12

ORGANIZATIONAL PLAN

The DSM-IV system has become the most well established and widely used of diagnostic classification systems in clinical practice with children with behavioral disorders. The DSM-IV system is divided into five axes to provide for the assessment of multiple domains of information. These axes are described as follows.

Axis I: Clinical Disorders and Other Conditions

The first axis consists of most of clinical mental disorders and other conditions that may be a focus of clinical attention. They are grouped into 16 major diagnostic classes. The first section is devoted to disorders usually first diagnosed in infancy, childhood, and adolescence (Table 6-1). Communication Disorders; Pervasive Developmental Disorders; Attention-Deficit and Disruptive Behavior Disorders; Feeding and Eating Disorders of Infancy or Early Childhood; Tic Disorders; Elimination Disorders; and Other Disorders of Infancy, Childhood, or Adolescence. However, some individuals with disorders that may be diagnosed during childhood (e.g., ADHD) may not present for clinical attention until adulthood. Moreover, it is not uncommon for the age at onset of many disorders in other sections (e.g., Major Depressive Disorder) to begin during childhood or adolescence. Significant controversy has arisen about when bipolar disorders are likely to manifest.13 Other diagnoses that are not specific to children but are applicable for children and adolescents include Anxiety, Mood Disorders, Eating Disorders, Somatoform Disorders, and Substance Use Disorders.

TABLE 6-1 DSM-IV Axis I Disorders

DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (American Psychiatric Association); NOS, not otherwise specified.

CLINICAL USE AND LIMITATIONS

The DSM system has become the standard for diagnosing mental disorders. It provides criteria for establishing diagnoses of mental disorders in the United States and other countries. The criteria are widely accepted for both research and clinical purposes, and both structured interviews and rating scales have been developed on the basis of this system. Third-party payers have used the system as their basis for reimbursement, and federal and state agencies use the diagnostic categories for providing services and funding research.

Despite its broad utility, however, the DSM is by no means a perfect system from a scientific and clinical standpoint in the field of developmental-behavioral pediatrics. Limitations of this system include the fact that it is not developmentally based and provides only a dichotomy of disorders, being present or absent, rather than a continuum. Moreover, the same diagnostic criteria are required for all patients regardless of age. In addition, the DSM system addresses developmental issues inconsistently. For example, in conditions such as mental retardation or learning disabilities, the testing process to establish the diagnosis provides for the variations anticipated for age. On the other hand, conditions such as ADHD or major depressive disorder require the same number of behavioral manifestations regardless of age. Developmental changes can be used to define the appropriate manifestation or frequency of particular behaviors, but developmental criteria remain loosely defined and therefore very subjective.

A critical assumption in the DSM system is that an individual’s symptoms either meet the criteria for a particular disorder or fall within a normal range. However, many of the characteristics of the disorders may be present in varying degrees along a spectrum. This situation can be present in children who manifest behaviors severe enough to cause problems for the child but not severe enough to be characterized as a disorder. Children in this situation have been referred to as having a “subthreshhold” condition. Children with subthreshhold conditions have tended to be much more of a focus in primary care settings than in the mental health service sector.

The occurrence of behavioral symptoms along a spectrum leads to much subjectivity in defining the boundaries of many disorders. The difficulty has been most prominent for ADHD, resulting in concerns about how many children receive a diagnosis of this condition14 and wide variations in the prevalence rates of how many children are being treated for the condition.15

International Classification of Diseases, 10th Edition (ICD-10)

HISTORY

A unified classification of diseases started in 1853 at the First International Statistical Congress. The Bertillon Classification of Causes of Death was a synthesis of English, German, and Swiss classifications that was general accepted internationally at the end of the 19th century and was accepted by the American, Canadian, and Mexican organizations in 1898. In 1929, a Mixed Commission made up of representatives of the International Statistical Institute and the Health Organization of the League of Nations developed the Fourth Revision of the International List of Causes of Death; this was revised as the fifth edition in 1938. A recognition that morbidity needed to be included started in the earlier 1900s, so that the fourth revision included further subdivisions to reflect morbid conditions that were not causes of death. The sixth edition, titled International Classification of Diseases, was entrusted to the Interim Commission of the World Health Organization in 1948.

In the early 1960s, the Mental Health Program of the World Health Organization worked to improve the diagnosis and classification of mental disorders. These activities resulted in major revisions in the mental disorders, classified in the eighth edition. In both the eighth and ninth revisions, like DSM-II, the system contained the divisions between neurotic and psychotic disorders. However, the 10th edition (ICD-10), published in 1992,11 took a more atheoretical approach, similar to that of DSM-IV. The number of categories expanded from 30 in ICD-9 to 100 in ICD-10.

ORGANIZATIONAL PLAN

The mental disorders in ICD-10 are divided into ten categories: organic, including symptomatic, mental disorders (F00-09); mental and behavioral disorders caused by psychoactive substance use (F10-19); schizophrenia, schizotypal, and delusional disorders (F20-29); mood (affective) disorders (F30-39); neurotic, stress-related, and somatoform disorders (F40-49); behavioral syndromes associated with physiological disturbances and physical factors (F50-59); disorders of adult personality and behavior (F60-69); mental retardation (F70-79); disorders of psychological development (F80-89); and behavioral and emotional disorders with the onset usually occurring in childhood and adolescence (F90-98). The behavioral and emotional disorders with onset usually occurring in childhood and adolescence and the disorders of psychological development are presented in Table 6-2.

TABLE 6-2 ICD-10: Behavioral and Emotional Disorders with Onset Usually Occurring in Childhood and Adolescence and Disorders of Psychological Development

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