Published on 22/03/2015 by admin
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Chapter 558 Defects of Thyroxine-Binding Globulin
Stephen LaFranchi
Abnormalities in levels of thyroxine-binding globulin (TBG) are not associated with clinical disease and do not require treatment. They are usually uncovered by a chance finding of abnormally low or high levels of thyroxine (T4) and may be a source of confusion in the diagnosis of hypothyroidism or hyperthyroidism.
TBG deficiency occurs as an X-linked dominant disorder. Congenital TBG deficiency is most often discovered through screening programs for neonatal hypothyroidism that use levels of T4 as the primary screen. Affected patients have low levels of T4 and elevated resin triiodothyronine uptake (RT3U), but levels of free T4
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