Choroidal Metastases

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Chapter 151 Choroidal Metastases

Introduction

Choroidal metastases are the most common of adult intraocular tumors.1,2 Autopsy studies suggest that approximately 10% of cancer patients have ocular metastases, most frequently to the choroid.1,3 Pathologies such as breast cancer are associated with higher rates approaching 40% late in the course of the disease.4 Of the cases, 20–40% are bilateral, and multifocal involvement of one eye occurs in approximately 20% of affected cases.5 Frequency of metastases does not differ for the right or the left eye.5

Symptoms and clinical findings

Intraocular metastases may be asymptomatic. When symptomatic, choroidal metastases cause painless visual loss by involvement of the macular area or peripapillary retina or because of an associated, generally exudative, retinal detachment.6,7 Retinal detachment may cause visual deficits, floaters and flashes. Larger retinal detachments may be associated with peripheral field deficits. Tumors located anteriorly may tilt the lens, thereby causing visual loss. Rarely, these patients may have painful visual loss as a result of neovascular glaucoma or metastatic iritis.

In a review of 70 patients with choroidal metastases, symptoms at presentation included: blurred vision in 80%; pain in 14%; photopsias in 13%; red eye and floaters in 7%; field defects in 3%, and photophobia in 1%. A total of 6% of patients were asymptomatic.8

The most common location for choroidal metastases is the posterior pole of the globe. Up to 40% of lesions have been reported to be in the macular region.9 The reason for this may be due to differential blood flow to that area, although macular metastases are also more likely to be symptomatic, therefore increasing the likelihood of diagnosis.

In contrast to choroidal melanomas which are generally darkly pigmented, choroidal metastases more commonly present as yellow or white lesions (Fig. 151.1). For lesions of a comparable basal size, choroidal metastases are often flatter than choroidal melanomas. Serous retinal detachment is commonly associated and frequently not in proportion with the tumor size.8,10

Frequency of primary cancer site

The relative frequency of primary cancer site for patients with choroidal metastases varies by gender. A series of more than 500 patients from the Wills Eye Hospital11 revealed primary sites for women as follows: breast, 68%; lung, 12%; unknown, 12%; gastrointestinal, 2%; skin, 1%; renal, <1%; and other, 4%. For men, primary sites were: lung, 40%; unknown, 29%; gastrointestinal, 9%; prostate, 6%; renal, 6%; skin, 4%; breast, 1%; and other, 4%.

Diagnostic evaluation

Differential diagnosis

Bilateral or multifocal findings are important clues to the diagnosis, since many simulating lesions tend to be unilateral and unifocal. Unilateral lesions are harder to diagnose. An extremely important diagnostic clue, if present, is a history of a known primary tumor. Many lesions may be confused with choroidal metastases, e.g., choroidal melanoma, choroidal osteoma, choroidal hemangioma, choroidal neovascularization with disciform scar, posterior scleritis, and other rare lesions.

Metastatic tumors usually have a creamy yellow appearance; purely amelanotic lesions are more likely to represent amelanotic choroidal melanomas. Metastatic lesions are usually flatter and rarely show the mushroom-shaped configuration that is often seen with melanomas. Choroidal metastases are also generally located in the posterior pole. Metastatic lesions anterior to the equator and metastases that involve the ciliary body are uncommon, and therefore amelanotic choroidal melanoma is more likely to be diagnosed in those locations. Bilateral or multifocal lesions are more likely to be metastatic, infectious, or uveitic. Combined A- and B-scan ultrasonography is of value in differentiating metastases from primary choroidal melanomas. Choroidal melanomas usually have low to moderate internal reflectivity, whereas metastatic lesions usually have higher internal reflectivity.12,13 More recently, optical coherence tomography has become useful to assist with the differential diagnosis of choroidal tumors.14

Choroidal osteomas may be bilateral and may have a color similar to that of metastatic tumors. Osteomas are rarely significantly elevated, and associated choroidal neovascularization is more common in patients with choroidal osteomas than in those with metastases. Ultrasound examinations15 and computed tomography (CT) scans are extremely valuable diagnostic tools in these patients because the bony change in the choroid shows very high reflectivity on ultrasound examination, and bone density can be confirmed with the CT scan.16 Optical coherence tomography may show overlying photoreceptor changes.17

Circumscribed choroidal hemangiomas are almost always unilateral and unifocal. Their characteristic reddish orange coloration is an important diagnostic clue. Fluorescein angiography shows more prominent early choroidal filling than is usually seen with metastatic lesions.16 Optical coherence tomography features of hemangioma have also been reported.18

Although some inflammation may be associated with a choroidal metastasis, inflammation is generally not prominent, but it can be seen, sometimes associated with choroidal detachment.19 A number of inflammatory conditions should be distinguishable, including Harada disease, the uveal effusion syndrome, posterior scleritis, and similar entities.16 In these patients, associated vitreous inflammation is often seen, and diffuse thickening of the choroid usually can be demonstrated on ultrasound examination.

Rarely do patients with large disciform scars or subretinal hemorrhages present a confusing picture. There is usually a history of previous visual loss related to choroidal neovascularization, and a history of systemic cancer is much less common. Drusen are usually apparent in the fellow eye. The echograms may be difficult to interpret, and the eyes are occasionally enucleated owing to a mistaken diagnosis of choroidal melanoma.20 The whitish yellow color of choroidal metastases is usually quite different from the darker appearance of these lesions, in which admixed blood is a prominent feature.

A- and B-scan ultrasonography

B-scan ultrasonography is of value in evaluating patients with media opacities or bullous retinal detachments when a choroidal lesion is suspected but cannot be clearly seen. The B-scan ultrasonogram shows an echogenic subretinal mass with diffuse, ill-defined borders. Overlying retinal detachment is common, and sound attenuation in the lesion is usually moderate.13 In unusual cases, choroidal detachment may be seen.19

The A-scan ultrasonogram usually demonstrates moderate to high internal reflectivity. Vascularity is not prominent, and the consistency is solid.12,13 It is useful to determine the height of the metastatic tumor by ultrasonography, so that shrinkage of the lesion can be documented after treatment. A more complete discussion of the ultrasonographic features of choroidal metastases is provided in Chapter 9 (Diagnostic ophthalmic ultrasound), as well as in standard texts.15 Magnetic resonance imaging and spectroscopy may also prove to be valuable differential diagnostic aids.23,24

Fine-needle aspiration biopsy

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