chapter 12
Back Pain and Common Leg Problems With or Without Difficulty Walking
Patients experience difficulty walking as a result of pain in their legs, and the commonest cause of pain is arthritis of the joints in the lower limbs. In the absence of pain, altered strength (which may be due to a lower motor or upper motor neuron problem) or sensation (particularly proprioception) in the lower limbs or impaired balance resulting from either a cerebellar disturbance or vestibular problem may cause difficulty walking. In the absence of pain, weakness or altered sensation, patients may experience difficulty walking related to Parkinson’s syndrome or a condition often confused with Parkinson’s that is termed apraxia of gait.
Difficulty walking that is related to central nervous system problems will be discussed in Chapter 13, ‘Abnormal movements and difficulty walking due to central nervous system problems’.
BACK PAIN
The first is principle is to establish exactly where in the back the pain is:
• Most low back (lumbar) pain is non-specific and relates to problems affecting soft tissues or is related to degenerative disease of the lumbosacral spine.
• On the other hand thoracic back pain may be more sinister:
• Patients who subsequently develop malignant cord compression often experience thoracic back pain for days or weeks prior to the onset of the neurological symptoms.
• Pain related to osteoporotic vertebral fractures is commonly in the thoracic region.
• Rarely, thoracic back pain may be the presenting symptom of a ruptured aortic aneurysm.
• If there is an associated radiculopathy (sciatica), the degenerative disease or lumbar disc disease may be the cause.
• Routine imaging early on in the course of low back pain is of no benefit [1]. An MRI scan can detect spinal metastases in patients with normal plain X-rays or CT scan [2]. A nuclear bone scan can also detect metastases in the vertebral column before cord compression but MRI is superior [3].
• In most patients with low back pain, symptoms resolve without surgical intervention:
• Physical therapy and non-steroidal anti-inflammatory drugs (NSAIDs) are the cornerstones of non-surgical treatment [4].
• Superficial heat is the only therapy with good evidence of efficacy for treatment of acute low back pain.
• Bed rest is often advocated for the treatment of acute low back pain but continuing ordinary activity may lead to a more rapid recovery [5].
• There is conflicting evidence of efficacy for spinal manipulation in low back pain [6, 7].
• Massage and acupuncture are better than no treatment but have not been compared to conventional treatment.
PROBLEMS IN THE UPPER LEG
MERALGIA PARAESTHETICA
• Symptoms may be intermittent initially, but subsequently the patient may develop permanently altered sensation.
• Symptoms vary from a mildly altered sensation over the anterolateral aspect of the thigh, often only noticed when the patient touches the thigh or clothes brush up against the thigh, to a more marked alteration in sensation with persistent numbness within the distribution of the lateral cutaneous nerve of the thigh but not always involving the entire extent.
• Some patients complain of pain and others may experience dysaesthesia, an unpleasant sensation when the skin is touched. This condition is due to compression of the lateral cutaneous nerve of the thigh beneath the inguinal ligament just medial to the anterior superior iliac spine and pressure over this point is often associated with tenderness.
• The presence of weakness or an altered knee reflex excludes the diagnosis.
Examination: The simplest test is to stroke the skin over the lateral aspect of the thigh and, if there is altered sensation, test in all directions, mapping out the exact pattern and sensory loss. The patient is then shown Figure 12.1 and immediately identifies the problem.
Another diagnostic test is to inject local anaesthetic in the region of the lateral cutaneous nerve beneath the inguinal ligament; a transient resolution of symptoms is considered diagnostic [9].
Pain and weakness in the upper leg
DIABETIC AMYOTROPHY/FEMORAL AMYOTROPHY/LUMBOSACRAL NEURITIS
• Increasingly severe pain in the buttocks, hips and thighs developing over hours to days is the initial presenting symptom. It is most often unilateral but, as in brachial neuritis, the contralateral side may be involved, usually within 1–2 weeks.
• In addition to the pain, severe weakness and subsequently marked wasting of the quadriceps muscles occurs with or without parasthaesia in the anterior aspect of the thigh and at times the shin. The weakness can be so severe to render the patient unable to walk.
Examination: The examination reveals weakness of hip flexion and knee extension with an absent knee-jerk. Although it may occur at any age, lumbosacral neuritis is more common in the middle-aged to elderly [13].
The aetiology of these conditions is uncertain but it is thought to be based on an inflammatory vasculitis [12, 14].
POLYMYALGIA RHEUMATICA
Polymyalgia rheumatica is a condition seen in middle-aged to elderly patients.
Symptoms: It presents with aching and stiffness predominantly affecting the shoulders but in 50–70% of cases may also affect the hips [17]. The condition is thought to relate to synovitis of the proximal joints and extra-articular synovial structures. The pain is constant day and night, as opposed to osteoarthritis of the hips where the pain mainly occurs on weight bearing. It often radiates to the knee and is exacerbated by movement of the hip joints. Although initially it may be unilateral, almost invariably patients develop bilateral symptoms.
A low-grade fever, fatigue and anorexia may occur in as many as 40% of patients and the presence of high spiking fevers should alert the clinician to the possibility of an associated giant-cell arteritis affecting the aorta and major branches. This can result in constant headaches, scalp tenderness and jaw claudication (see Chapter 9, ‘Headache and facial pain’, for further discussion).
DRUG-INDUCED MUSCLE PAIN AND/OR WEAKNESS
A large number of pharmaceutical agents, including lipid lowering agents, NSAIDs, antineoplastic drugs and even over-the-counter essential amino acids, such as L-tryptophan, can result in myalgia or even myositis causing muscle pain, cramps, swelling, tenderness and weakness [19, 20]. This list is almost certain to enlarge with the advent of new therapeutic agents.
Weakness in the upper leg
Patients present with the insidious onset of proximal weakness in the legs in the absence of sensory disturbance. The weakness is bilateral but may be asymmetrical. Pain in the muscles occurs in approximately 50% of cases but, as opposed to the above two conditions, is rarely severe. Dysphagia, neck weakness and impaired respiratory function may occur [21]. Inclusion body myositis affects the long flexors of the fingers and, in the lower limbs, the extensor muscles of the knees and hip flexors, resulting in significant proximal weakness. In this latter condition the knee reflex is often absent, whereas in polymyositis and dermatomyositis the reflexes are preserved.
MUSCLE WEAKNESS DUE TO ENDOCRINE DYSFUNCTION
Hyperthyroidism, hypothyroidism and Addison’s disease may all present with muscle weakness. Usually there are associated manifestations to point to the underlying endocrine disorder. Hyperthyroidism may also present with periodic paralysis [24] or rhabdomyolysis [25] and hypothyroidism may present with muscle hypertrophy [26].
The weakness will resolve with correction of the endocrine disturbance.
PROBLEMS IN THE LOWER LEGS AND FEET
Unpleasant sensations in the feet
In the lower leg and feet patients can experience unpleasant sensations at rest that can cause difficulty walking or unpleasant sensation at rest improved by walking or, in fact, that can be improved by walking. Figure 12.2 shows an approach to patients with discomfort or unpleasant sensation in their feet. Erythromelalgia and painful legs moving toes are extremely rare.
FIGURE 12.2 Suggested approach to pain in the feet
There are many non-neurological causes of pain in the feet where pain is either exacerbated or precipitated by weight bearing and/or walking. These include osteoarthritis in the ankle or joints of the feet, a calcaneal spur and plantar fasciitis. The neurological causes of pain in the feet that can result in difficulty walking due to pain include Morton’s neuroma or metatarsalgia and tarsal tunnel syndrome. All will have pain with weight bearing, but there are subtle differences in the nature of the pain and the presence of altered sensation that occurs with the neurological causes to help differentiate the various entities.
UNPLEASANT SENSATIONS AT REST THAT DO NOT CAUSE DIFFICULTY WALKING
Restless legs syndrome: Restless legs syndrome [27–31] is common, affecting 5% of the population. However, many patients complain that most doctors do not seem to be aware of the entity or know much about it. A more appropriate term is restless limbs syndrome because in more severe cases it can also affect the upper limbs and, rarely, symptoms may be confined to the upper limbs.
The essential features of RLS are:
• Patients develop symptoms when they are not moving, such as prolonged sitting at the dinner table, on an aeroplane or in a lecture or movie.
• Symptoms are particularly severe in bed at night.
• Patients find it very difficult to describe the nature of the symptoms except to say that they are unpleasant.2
• Patients cannot keep their limbs still because of this unpleasant sensation that feels deep inside the limb, not over the surface or affecting just the skin.
• The pain is in the feet, shins, calves and often seems to cross joints but is not confined to the joints.
• Symptoms persist on and off for hours until patients are forced to be up and about.
• Both legs are usually affected although the symptoms can be either confined to or more severe in one leg.
• Patients invariably pace the floor at night to obtain relief but, unlike burning feet syndrome, they do not need to walk on cold surfaces and the symptoms are not relieved by moving the feet to where the sheets are colder.
• There are no symptoms during the day unless the patient sits down.
• Sleep is disturbed whether the patient is sleeping at night or during the day.
• The neurological examination of the affected limbs should be completely normal, although sometimes this condition is associated with a peripheral neuropathy, so patients should be examined specifically looking for absent ankle reflexes, weakness of dorsiflexion of the toes and feet and possible peripheral sensory loss affecting the toes and distal aspect of the feet.
The characteristic feature of PVD is exercise-induced leg pain relieved by rest but occasionally it can cause pain at rest. The symptoms are confined to the lower limbs and upper limb symptoms would exclude this diagnosis. The pain is usually in the feet and calves; very rarely, buttock pain can occur due to involvement of the internal iliac artery. The peripheral pulses will be difficult to palpate with PVD.