Anatomy of the Respiratory System

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Anatomy of the Respiratory System

Boundaries and Functions of the Upper Airway

Boundaries: From the anterior nares to the true vocal cords.

Functions:

The nose

1. The nose is a rigid structure of cartilage and bone; the superior one third is made up of the nasal and maxilla bones, and the inferior two thirds is made up of five large pieces of cartilage (Figure 4-1).

2. The two external openings are called the nostrils, external nares, or anterior nares. Their lateral borders are termed the alae.

3. The nasal cavity is divided into two nasal fossae by the septal cartilage.

4. Each nasal fossa is divided into three regions: vestibular, olfactory, and respiratory.

a. Vestibular region: An area of slight dilation inside the nostril, bordered laterally by the alae and medially by the nasal septal cartilage.

(1) The vestibular region is lined with stratified squamous epithelium (Table 4-1). Layers of relatively flat cells continuously are being produced, replacing those lost at the surface.

TABLE 4-1

Anatomical Comparison of Epithelium in Upper Respiratory Tract

Structure Epithelium
Vestibular region/nose Stratified squamous
Olfactory region/nose Pseudostratified columnar
Respiratory region/nose Pseudostratified ciliated columnar
Paranasal sinuses Pseudostratified ciliated columnar
Nasopharynx Pseudostratified ciliated columnar
Oropharynx Stratified squamous
Laryngopharynx Stratified squamous
Larynx/above true cords Stratified squamous

(2) Coarse nasal hairs (vibrissae) project anteriorly and inferiorly.

(3) Sebaceous glands secrete sebum, a greasy substance that keeps the nasal hairs soft and pliable.

(4) The nasal hairs are the first line of defense for the upper airway, acting as very gross filters of inspired air.

b. Olfactory region: An area in each nasal cavity defined by the superior concha laterally, nasal septal cartilage medially, and roof of the nasal cavity superiorly.

(1) Contained is the olfactory epithelium responsible for the sense of smell.

(2) The olfactory epithelium is yellowish brown and appears as pseudostratified columnar epithelial cells. These cells are interspersed with more deeply placed olfactory cells, whose sensory filament, the olfactory hairs, protrudes to the epithelial surface. Similar in structure to the ciliated cells lining the respiratory region but without the cilia (Figure 4-2).

(3) Largely because of the architecture of the nasal cavity, sniffing causes inspired gases to be drawn to the olfactory region and not much farther into the respiratory tract. This provides a protective mechanism for sampling potentially noxious environmental gases.

c. Respiratory region: An area in each nasal cavity inferior to the olfactory region and posterior to the vestibular region. The respiratory region comprises most of the surface area of the nasal fossa.

(1) Contained in the respiratory region of each nasal fossa are three bony plates called turbinates or conchae. The turbinates extend in a medial and inferior direction from the lateral walls of the nasal fossa.

(2) The three turbinates or conchae (superior, middle, and inferior) overhang and define the three corresponding passageways through each nasal cavity, respectively, the superior, middle, and inferior meati (see Figure 4-1).

(3) Because of the arrangement of the turbinates and folded mucous membrane covering the turbinates in the nose, the respiratory region has a volume of approximately 20 ml and a remarkably large surface area of approximately 160 cm2.

(4) Turbulent flow is created through this region.

(5) Heating, humidifying, and filtering of inspired gases are accomplished by the turbulent flow through this region of the nose. The turbulent flow produces a greater probability that each gas molecule will come in contact with the large surface area of the vascular nasal mucous membrane. This large gas-to-nasal surface interface allows the following:

(6) The epithelial lining of the respiratory region of the nasal cavity is pseudostratified ciliated columnar epithelium (see Figure 4-2).

(a) The cells are cylindrical and appear to be two cell layers thick because of the high lateral pressures compressing the cells. Actually, the epithelium is only one cell layer thick, with each columnar cell making contact with the basement membrane.

(b) Each columnar cell has 200 to 250 cilia on its surface. Each of the cilia contains two central and nine paired peripheral fibrils. It is the sliding interaction of these fibrils that is thought to cause the beating of the cilia.

(c) Goblet cells and submucosal glands are interspersed throughout the epithelium and, along with capillary seepage, are responsible for production of mucus (100 ml/day in health).

(d) Mucus exists in two layers:

(e) On the forward stroke, the cilia become rigid. Their tips touch the undersurface of the gel layer and propel it toward the oropharynx. On the backward stroke, the cilia become flaccid, fold on themselves, and slide entirely through the sol layer to their resting position without producing a retrograde motion of the gel layer.

(f) The cilia of a particular cell and adjacent cells beat in a coordinated and sequential fashion that produces a motion similar to a wave. This allows a unidirectional flow of mucus. The cilia beat approximately 1000 to 1500 times/min and move the mucous layer at a rate of 2 cm/min.

(g) Functions of the mucus and pseudostratified ciliated columnar epithelium (mucociliary blanket) are:

5. The nose is responsible for one half to two thirds of the total airway resistance during nasal breathing. Therefore, it is not surprising that mouth breathing predominates during stress (e.g., exercise or disease).

6. The nose ends with the outlet of the nasal cavity into the nasopharynx through the internal nares (posterior nares or choanae).

The oral cavity (see Figure 4-1)

1. The oral cavity extends from the lips to the palatine folds, a double web on each side of the oral cavity where the palatine tonsils reside.

2. The oral cavity is separated from the nasal cavity by the palate. The anterior two thirds is the bony hard palate, and the posterior one third, without bone, is the soft palate.

3. The oral cavity is considered an accessory respiratory passage because air usually only flows through it during stress and exercise.

4. The tongue attached to the floor of the cavity is involved in the mechanical aspects of swallowing, taste, and phonation.

5. The mucosal surface provides modest humidification and warming of inspired air.

6. Saliva is produced by groups of salivary glands.

Paranasal sinuses (see Figures 4-1 and 4-3)

1. Sinuses are cavities of air in the bones of the cranium.

2. The function of the sinuses is not clearly understood, but it may be twofold:

3. The sinuses are absent or rudimentary at birth and grow almost simultaneously with the development of the permanent teeth. Formation of the sinuses is responsible for the alteration in facial shape that occurs at this time.

4. All of the air sinuses are lined with pseudostratified ciliated columnar epithelium and produce mucus, which drains into the nasal meati.

5. If nasogastric tubes or nasotracheal intubation blocks sinus drainage, sinusitis and sinus infection often result.

6. Groups of paranasal sinuses: Frontal, maxillary, sphenoidal, and ethmoidal.

a. The frontal sinuses appear as paired sinuses medial to the orbits of the eye and superior to the roof of the nasal cavity between the external and internal surfaces of the frontal bone. They drain into the anterior portion of the middle meati (middle passageway [cavity] formed by the turbinates).

b. The maxillary sinuses appear as paired sinuses lateral to each nasal cavity and inferior to the orbits of the eye in the body of the maxilla. These sinuses, the largest of all the air sinuses, drain into the middle meati.

c. The sphenoidal sinuses appear as paired sinuses posterior and inferior to the roof of the nasal cavity and superior to the internal nares (choanae) in the body of the sphenoid bone. They drain into the superior meati.

d. The ethmoidal sinuses are paired sinuses that exist in three groups: anterior, medial, and posterior ethmoidal. They exist just lateral to the superior and middle conchae, medial to the orbits of the eyes, inferior to the frontal sinuses, and superior to the maxillary sinuses in the ethmoid bone. The ethmoidal sinuses drain into the superior and middle meati.

Pharynx

1. The pharynx is a hollow muscular structure lined with epithelium (Figure 4-4).

2. Major functions

3. The pharynx is approximately 5 in. long and extends from the internal nares (choanae) inferiorly to the esophagus.

4. Sections of the pharynx: Nasopharynx, oropharynx, and laryngopharynx.

a. The nasopharynx is located behind the nasal cavity and extends from the internal nares superiorly to the tip of the uvula inferiorly.

(1) The epithelium is continuous with the epithelium of the nasal cavity and is pseudostratified ciliated columnar epithelium.

(2) The eustachian or auditory tubes open into the nasopharynx on each of its lateral walls and communicate with the tympanic cavity or middle ear (see Figure 4-1).

(3) The pharyngeal tonsil or adenoid is located in the superior and posterior wall of the nasopharynx.

(4) During the process of swallowing, the uvula and soft palate move in a posterior and superior direction to protect the nasopharynx and nasal cavity from the entrance of food, liquid, or both.

(5) Major functions of the nasopharynx:

b. The oropharynx is located behind the oral or buccal cavity and extends from the tip of the uvula superiorly to the tip of the epiglottis inferiorly.

c. The laryngopharynx or hypopharynx extends superiorly from the tip of the epiglottis to a point inferiorly where it bifurcates into the larynx and esophagus.

II Boundaries and Functions of the Lower Airway

Boundaries: From the true vocal cords to the terminal air spaces (alveoli).

Functions:

The larynx (Figures 4-5 and 4-5)

1. The larynx is a boxlike structure made of cartilage connected by extrinsic and intrinsic muscles and ligaments. It is lined internally by a mucous membrane.

2. Functions

3. The larynx extends from the third to sixth cervical vertebrae in the anterior portion of the neck.

4. Unpaired cartilages of the larynx: Epiglottis, thyroid, and cricoid (see Figure 4-5).

a. Epiglottic cartilage

b. Thyroid cartilage

c. Cricoid cartilage

5. Paired cartilages of the larynx: Arytenoid, corniculate, and cuneiform (see Figure 4-6).

a. Arytenoid cartilages

b. Corniculate cartilages

c. Cuneiform cartilages

6. Extrinsic ligaments of the larynx

7. Intrinsic ligaments of the larynx

a. Intrinsic ligaments attach cartilages of the larynx to one another.

b. The thyroepiglottic ligament attaches the inferior aspect of the epiglottis to the thyroid cartilage on its internal surface below the thyroid notch.

c. The aryepiglottic ligament attaches the arytenoid cartilages to the epiglottis and acts as a point of attachment for the aryepiglottic folds.

d. The cricothyroid ligament attaches the anterior portion of the thyroid cartilage to the anterior portion of the cricoid cartilage. It is through this ligament that an emergency cricothyroidotomy is performed.

e. The vocal ligament is a thick band that stretches from the vocal process of the arytenoid cartilages across the cavity of the larynx to attach to the thyroid cartilage just inferior to the thyroepiglottic ligament. The lateral borders of the vocal ligament attach to the inverted free borders of the cricothyroid ligament.

f. The ventricular ligament is a thick band that stretches from the arytenoid cartilage across the cavity of the larynx to the thyroid cartilage. It exists superior and lateral to the vocal ligament.

8. Cavity of the larynx (see Figure 4-6)

a. The larynx is divided into three sections by the pair of ventricular folds and vocal folds.

b. The upper section, the vestibule of the larynx, extends from the laryngeal inlet to the level of the ventricular folds.

c. The middle section, the ventricle of the larynx, extends from the ventricular folds to the vocal cords.

(1) The vocal folds are the true vocal cords.

(2) The space between the vocal folds is the rima glottidis or glottis.

(3) The size of the rima glottidis also is variable, depending on the state of the vocal cords (see Figure 4-6).

(4) The glottic or sphincter mechanism requires aryepiglottic folds, epiglottis, ventricular folds, and vocal folds to act in a coordinated fashion to seal the laryngeal inlet.

d. The lower section, the subglottic cavity of the larynx, extends from the vocal folds to the cricoid cartilage.

e. The epithelial lining of the larynx above the true vocal cords is continuous with the laryngopharynx and is stratified squamous epithelium (see Table 4-1).

f. The epithelial lining of the larynx below the true vocal cords is pseudostratified ciliated columnar epithelium, the same as that in the trachea.

Tracheobronchial tree and lung parenchyma (Figure 4-7)

Trachea (generation 0)

1. The trachea is a cartilaginous, membranous tube 10 to 13 cm in length and 2 to 2.5 cm in diameter.

2. The trachea extends from the cricoid cartilage at the sixth cervical vertebra to its point of bifurcation (carina) at the fifth thoracic vertebra.

3. Sixteen to 20 incomplete (C-shaped) cartilaginous rings open posteriorly and are arranged horizontally. The open ends of the cartilage and the area between individual cartilages are joined by a combination of fibrous, elastic, and smooth muscle tissue.

4. The posterior wall of the trachea is separated from the anterior wall of the esophagus by loose connective tissue.

5. The trachea and following large airways (bronchi) contain three characteristic layers (Figure 4-8):

6. The epithelial lining of the trachea is continuous with the larynx above and consists of pseudostratified ciliated columnar epithelium (Table 4-2).

TABLE 4-2

Anatomical Comparison of Structures in the Lower Respiratory Tract

Structure Epithelium Division
Larynx/below true cords Pseudostratified ciliated columnar X
Trachea Pseudostratified ciliated columnar 0
Mainstem bronchi Pseudostratified ciliated columnar 1
Lobar bronchi Pseudostratified ciliated columnar 2
Segmental bronchi Pseudostratified ciliated columnar 3
Subsegmental bronchi Pseudostratified ciliated columnar 4-9
Bronchioles Pseudostratified ciliated columnar 10-15
Terminal bronchioles Cuboidal to simple squamous 16
Respiratory bronchioles Simple squamous 17-19
Alveolar ducts Simple squamous 20-22
Alveolar sacs Simple squamous 23
Alveoli Type I; squamous
  Type II; granular
  Type III; macrophage

Mainstem bronchi (generation 1)

1. The trachea bifurcates into two airways, the right and left mainstem bronchi, at the carina. The carina is generally located at the level of the fifth thoracic vertebra.

2. A portion of mainstem bronchi is extrapulmonary (exists outside the lung in the mediastinum), but the majority of it is intrapulmonary (inside the lung proper).

3. The structural arrangement of the mainstem bronchi is the same as that of the trachea, with C-shaped pieces of cartilage, a lamina propria, and pseudostratified ciliated columnar epithelium (see Figure 4-8).

4. The only structural difference between the mainstem bronchi and the trachea is that the intrapulmonary section of the mainstem bronchi is covered with a sheath of connective tissue, the peribronchiolar connective tissue.

5. Mainstem bronchi are sometimes referred to as primary bronchi.

Lobar bronchi (generation 2)

Segmental bronchi (generation 3)

Subsegmental bronchi (generations 4-9)

Bronchioles (generations 10-15)

1. Diameter is characteristically approximately 1 mm.

2. Cartilage is totally absent (see Figure 4-9).

3. Peribronchiolar connective tissue is absent; the lamina propria of these airways is directly embedded in surrounding lung parenchyma.

4. Airway patency is dependent not on the structural rigidity of surrounding cartilage but on fibrous, elastic, and smooth muscle tissue.

5. The epithelial lining of bronchioles is pseudostratified ciliated cuboidal epithelium (short squat cells as opposed to the elongated columnar cells).

Terminal bronchioles (generation 16)

1. Average diameter is 0.5 mm and represents a cross-sectional area of approximately 116 cm2.

2. Goblet cells and submucosal glands disappear, although mucus is found in these airways (see Figure 4-9).

3. Cilia are absent from the epithelium of terminal bronchioles. This epithelium serves as a transition from the cuboidal epithelium of generation 15 to the squamous epithelium of generation 17.

4. Clara cells are located in the terminal bronchioles.

5. Terminal bronchioles mark the end of the conducting airways; all airway generations distal to the terminal bronchioles are considered part of the lung parenchyma (Figure 4-10).

Respiratory bronchioles (generations 17-19)

Alveolar ducts (generations 20-22)

Alveolar sacs (generation 23)

Alveoli (Figure 4-11)

Alveolar capillary membrane or alveolar septum (Figure 4-12)

1. The alveolar capillary membrane has four components: surfactant layer, alveolar epithelium, interstitial space, and capillary endothelium.

a. The surfactant is composed of a phospholipid attached to a lecithin molecule.

b. Alveolar epithelium (simple squamous epithelium) is a continuous layer of tissue made up of type I and II cells lying on a basement membrane (see Table 4-2).

c. The interstitial space is the area that separates the basement membrane of alveolar epithelium from the basement membrane of capillary endothelium.

d. Capillary endothelium is a continuous layer of tissue made up of flat, interlocking squames supported on a basement membrane.

2. Thickness of the alveolar capillary membrane varies from 0.35 to 1 μm.

III The Lungs

The lungs are situated in the thoracic cavity separated by a structure (mediastinum) containing the heart, great vessels, esophagus, and trachea (Figure 4-13).

The lung is a conical-shaped organ with four surfaces: apex, base, medial surface, and costal surface (Figure 4-14).

The root of the lung enters the lung proper at the hilum.

The right lung is divided into three lobes by the horizontal and oblique fissures (see Figure 4-14).

The left lung is divided into two lobes by the oblique fissure.

The lobes of the lung are further subdivided into segments (Figure 4-15).

The segments are further subdivided into secondary lobules.

1. Secondary lobules consist of a 15th-order airway (bronchiole) and its associated three to five terminal bronchioles and their distal respiratory bronchioles, alveolar ducts, and alveolar sacs.

2. The secondary lobule is the smallest self-contained unit of the lung that is surrounded by connective tissue.

3. Secondary lobules appear as polyhedral masses observable on the lung surface and as dark intersecting lines between fissures.

4. Secondary lobules have their own discrete single pulmonary arteriole, venule, lymphatic, and nerve supply.

5. Secondary lobules are the building blocks of segments and are discernible on chest radiography.

6. Each secondary lobule comprises 30 to 50 primary lobules and measures 1 to 2.5 cm in diameter.

7. Secondary lobules may be important in isolating and maintaining disease locally. They also may be responsible for local matching of ventilation to perfusion.

Bronchiolar and alveolar intercommunicating channels

Innervation of the lungs

1. Afferent and efferent pathways of the autonomic nervous system innervate the lungs.

2. The afferent or sensory pathways originate in the epithelium of the bronchial walls, submucosa, interalveolar septa, and smooth muscles.

3. Parasympathetic fibers via the vagus nerves arranged in three groups of sensory fibers have been identified.

a. Pulmonary stretch receptors, which are slowly adapting.

b. Irritant, rapidly adapting

c. C-fiber–pulmonary type J receptors

(1) Located in alveolar walls, airways, and blood vessels.

(2) Stimulated by:

(3) Response to stimulation:

(4) Efferent or motor pathways reach the lung through the sympathetic and parasympathetic nervous system.

(5) The sympathetic fibers terminate in the airway walls, vascular smooth muscle, and submucosal glands; stimulation causes:

(6) Stimulation of the parasympathetic motor fibers in the airways causes:

Bronchial circulation

1. The metabolic needs of the airways are provided by the bronchial arteries, which originate from the aorta or the upper intercostal arteries.

2. These vessels accompany the bronchial tree down to the terminal bronchioles.

3. Structures distal to the terminal bronchioles are believed to obtain their nutrients from the mixed venous blood of the pulmonary circulation.

4. The bronchial circulation is approximately 1% to 2% of the cardiac output.

5. A portion of the venous blood from the capillaries of the bronchial circulation returns to the right heart by way of the:

6. The remainder of the bronchial circulation returns to the left heart by way of the:

7. Blood emptying into the left heart is termed venous admixture.

IV Bony Thorax (Figure 4-16)

It is a bony and cartilaginous frame within which lie the principal organs of circulation and respiration.

It is conical and narrow above and broad below.

Posteriorly, the thorax includes the 12 thoracic vertebrae and the posterior portion of the ribs.

Laterally, the thorax is convex and formed by the ribs.

Anteriorly, it is composed of the sternum, anterior ends of the ribs, and the costal cartilage.

The superior opening into the thorax—defined by the manubrium, first rib, and first thoracic vertebra—is called the thoracic inlet or operculum.

The inferior opening out of the thorax—defined by the 12th rib, costal cartilage of ribs 7 through 10, and 12th thoracic vertebra—is called the thoracic outlet.

Functions of the bony thorax are to protect underlying organs, aid in ventilation, and provide a point of attachment for various bones and muscles.

Sternum (see Figure 4-16)

Ribs (see Figure 4-16)

1. Twelve elastic arches of bone, posteriorly connected to the vertebral column.

2. Types of ribs: True, false, and floating.

3. True ribs

4. False ribs

5. Floating ribs

6. The space between the ribs is called the intercostal space.

7. All 12 pairs of ribs are positioned in an inferior direction. Contraction of the intercostal muscles elevates the ribs from their natural inclined position.

Muscles of Inspiration (Figure 4-17)

The diaphragm, external intercostal, parasternal intercostal, and scalene muscles are normally used for resting inspiration (Table 4-3).

TABLE 4-3

Muscles of Breathing

Muscle(s) Phase Use Origin Insertion Action
Costal diaphragm Inspiration Normal Inner surface of ribs 7-12 and sternum Central tendon Increases superior-inferior lung volume; lower lateral rib cage expansion
Crural diaphragm Inspiration Normal First 3 lumbar vertebrae Central tendon Increases superior-inferior lung volume; lateral rib cage expansion
Parasternal intercostals Inspiration Normal Costal cartilage Costal cartilage, sternum Lift ribs and sternum
Interosseous internal intercostals Expiration Accessory Costal cartilage Costal cartilage Pull ribs downward
External intercostals Inspiration Accessory Upper ribs Lower ribs Lift ribs forward and upward
Scalene, medius, and anterior Inspiration Normal Lower 5 vertebrae 1st and 2nd ribs Lift 1st and 2nd ribs and sternum
Sternomastoid Inspiration Accessory Manubrium sterni and clavicle Mastoid process and occipital bone Lift upper ribs
External oblique Expiratory Accessory Lower 8 ribs above the costal margins Iliac crest and inguinal ligament Constricts and compresses diaphragm
Internal oblique Expiratory Accessory Lumbar fascia, iliac crest, inguinal ligament Costal margin, pubis Constricts and compresses diaphragm
Transverse abdominis Expiratory Accessory Costal margin Midline aponeurosis of the rectus sheath Constricts and compresses diaphragm
Rectus abdominis Expiratory Accessory Costal cartilage of ribs 5-7 Pubis Constricts and compresses diaphragm
Pectoralis major Inspiration Accessory Clavicle Sternum, costal cartilage Lifts upper chest wall
Pectoralis minor Inspiration Accessory Ribs 3-5, near costal cartilage Scapula Lifts upper chest wall
Latissimus dorsi Expiratory (controversial) Accessory Lumbar and sacral vertebrae Humerus Stabilizes back and vertebral column
Serratus anterior Expiratory Accessory 8 upper ribs Scapula Stabilizes back and vertebral column
Serratus, posterior superior Expiratory Accessory Cervical and dorsal vertebrae Ribs 2-5 Stabilizes back and vertebral column
Serratus, posterior inferior Expiratory Accessory Dorsal and lumbar vertebrae Ribs 9-12 Stabilizes back and vertebral column

image

From Pierson DJ, Kacmarek RM: Foundations of Respiratory Care. New York, Churchill Livingstone, 1992. Churchill Livingstone

1. Diaphragm: Dome-shaped muscle that separates the thoracic from the abdominal cavity.

2. Intercostal muscles

3. Scalene (scalenus) muscles

Accessory muscles of inspiration

VI Accessory Muscles of Expiration (see Figures 4-17 and 4-18)

There are no muscles of quiet resting expiration. Expiration is purely a passive process brought about by the normal elastic tendencies of the lung coupled with cessation of inspiratory muscle contraction. Therefore, any muscles used for expiration are termed accessory muscles of expiration.

Any muscle usage for quiet resting expiration is abnormal.

Accessory muscles of expiration are used only for forced expiration, making expiration an active process.

The accessory muscles of expiration are of the back, thorax, or abdomen and tend to either pull the thorax down or support the thorax so that other muscle groups can effectively pull down on the thorax.

VII Other Functions of the Lung