Enveloped DNA Viruses
• All three subfamilies (alpha, beta, and gamma) contain significant human pathogens, which can establish primary lytic or persistent infection, as well as latent and recurrent infections (Table 22-1).
22-1 Pathogenesis and spread of varicella-zoster virus (VZV) within the body. VZV initially establishes lytic infection in mucoepithelial cells of the respiratory tract. Spread of virions by the reticuloendothelial (RE) system and bloodstream to other parts of the body causes flu-like symptoms (fever, malaise, and headache), followed by the appearance of the characteristic skin lesions of chickenpox. Reactivation of latent infection in neurons later in life causes herpes zoster (shingles). The spread of virions can be blocked by various components of the immune response at the indicated stages.