Wet Age-Related Macular Degeneration

Published on 09/05/2015 by admin

Filed under Opthalmology

Last modified 22/04/2025

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8.1

Wet Age-Related Macular Degeneration

Clinical Features:

The distinguishing feature is the presence of choroidal neovascularization (CNV) in the setting of a patient over the age of 60 years, virtually always with some manifestations of concurrent or pre-existing dry AMD (drusen, geographic atrophy, RPE abnormalities). CNV results in leakage of fluid and/or hemorrhage within or underneath the neurosenory retina, and/or underneath the RPE detachment visible on examination. On the basis of fluorescein angiography, CNV can be subtyped into classic, occult, or mixed. An anatomic classification divides CNV into type 1 (below the RPE), type 2 (above the RPE) or type 3 (retinal angiomatosis proliferation [RAP]). In the presence of a large pigment epithelial detachment (PED), a tear of the RPE can occur. End-stage wet AMD may results in disciform scar formation.

OCT Features:

The most characteristic findings on OCT in wet AMD are the presence of an irregularly shaped PED with adjacent subretinal hemorrhage and subretinal fluid. An irregularly shaped PED is in contrast to a more smooth-shaped PED typically seen in central serous chorioretinopathy. In wet AMD, especially in type 2 CNV, there is frequently a visible interruption in the RPE layer. There are various key features of wet AMD that can be uniquely identified based on their OCT appearance:

▶ Classic CNV: a classic, or type 2, CNV is present when the abnormal neovascular tissue penetrates the RPE/Bruch’s membrane complex and is present in the subretinal space (Figs 8.1.1 and 8.1.2).

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Figure 8.1.1 OCT of a classic choroidal neovascularization (far right). Corresponding thickness map (left) and infrared image (middle) are shown.

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Figure 8.1.2 Fluorescein angiography (corresponding to Figure 8.1.1) shows a well-defined region of hyperfluorescence that is visible in the early frames and grows in intensity in the late frames, but does not enlarge in size, characteristic of a classic choroidal neovascularization (red circle).

▶ Occult CNV: an occult, or type 1, CNV is present when the abnormal neovascular tissue remains underneath the RPE (Figs 8.1.3 and 8.1.4).

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Figure 8.1.4 OCT (corresponding to Figure 8.1.3) of an occult choroidal neovascularization (right) and corresponding thickness map (left), PED.

▶ RPE tear: an RPE tear has a very characteristic OCT appearance (Figs 8.1.5 and 8.1.6), where there is a sharply demarcated region of absent RPE adjacent to an area of bunched-up RPE.

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Figure 8.1.6 OCT of the same choroidal neovascularization shown in Figure 8.1.5 one month following treatment with intravitreal anti-VEGF therapy with resultant retinal pigment epithelium (RPE) tear. Due to the absence of the RPE in the region of the tear, reverse shadowing is seen in the deeper structures. The RPE is bunched up where it is still present, blocking deeper structures. There is also still a thin rim of subretinal fluid present. Corresponding infrared image is shown on the left, which helps to visualize the region of the RPE tear.

▶ Disciform scar: a disciform scar can have a varied OCT appearance but always is dominated by a hyper-reflective subretinal scar (Figs 8.1.7 and 8.1.8).

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Figure 8.1.8 OCT (corresponding to Figure 8.1.7) shows highly reflective subretinal material corresponding to the organized subretinal scar. A central intraretinal cyst is also present.

▶ Treated CNV: following treatment with anti-vascular endothelial growth factor (VEGF) therapy, intra- and subretinal fluid will often improve significantly or completely resolved (Figs 8.1.9 and 8.1.10). Associated PEDs also tend to decrease in size with continued treatment.

▶ Retinal angiomatous proliferation: type 3 CNV (or RAP), is a rare cause of exudative AMD resulting from abnormal neovascular tissue within the deep retina that typically originates within the retina and migrates towards the choriocapillaris and/or retinal surface (Figs 8.1.11 and 8.1.12).

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Figure 8.1.12 OCT (corresponding to Figure 8.1.10) shows a hyper-reflective area within the retina, thought to represent the retinal angiomatosis proliferation lesion. There is associated intraretinal cystic fluid and underlying subretinal fluid and pigment epithelial detachments.

▶ Polypoidal choidal vasculopathy (PCV): PCV is thought to be a variation of type 1, or occult, CNV where polyp-shaped abnormal vascular complexes are located underneath the RPE (Figs 8.1.13, 8.1.14 and Fig 8.1.15).

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Figure 8.1.15 OCT (corresponding to Figure 8.1.12) shows multiple, large, adjacent PEDs with overlying subretinal fluid. Exudate is also visible as hyper-reflective intraretinal spots.

▶ Isolated PED: in the setting of a large, isolated PED, it can sometimes be difficult to determine if co-existent wet AMD is present even with the addition of an FA. OCT can help to determine if overlying intra- or subretinal fluid is present or not, which would be the case in wet AMD (Fig 8.1.16).

Ancillary Testing:

Fluorescein angiography is helpful to confirm a diagnosis of wet AMD and for subtyping the lesion (Figs 8.1.2 and 8.1.4), though this was more useful historically when treatment decisions were based on lesion type. Indocyanine green angiography (ICGA) can help to differentiate less common AMD-subtypes that do not respond well to standard anti-VEGF therapy, such as PCV (Fig 8.1.15).