Uterine Cancer

Published on 04/03/2015 by admin

Filed under Hematology, Oncology and Palliative Medicine

Last modified 04/03/2015

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Uterine Cancer

John F. Boggess and Joshua E. Kilgore

Summary of Key Points

Incidence

• 46,000 estimated new cases per year

• Approximately 8,100 deaths per year from the disease

• Endometrioid adenocarcinoma arises in the endometrium and accounts for approximately 90% of cases

Biological Characteristics

• Median age is 63 years

• Most common presenting symptom is irregular vaginal bleeding

• Risk factors include unopposed estrogen therapy, obesity, chronic anovulation, tamoxifen use, diabetes, and nulliparity

Staging Evaluation

• Staging is surgical according to International Federation of Gynecology and Obstetrics (FIGO) guidelines

• Uterine sarcomas and carcinomas are staged differently

Primary Therapy and Results

• Primary surgery with hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy is curative in majority of cases

• Radiation alone may be used for inoperable patients and/or palliation

Adjuvant Therapy

• Risk factors for recurrence or extrauterine spread include deep myometrial invasion, moderate- to high-grade histology, and lymphovascular space invasion (LVSI)

• Adjuvant radiation may be used in patients with high-intermediate and high-risk disease

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